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Vitamin B12: Surprising New Findings

December 2000

By Terri Mitchell


Adachi S, et al. 2000. Enteral vitamin B12 supplements reverse postgastrectomy B12 deficiency. Ann Surg 232:199-201.

Akaike A, et al. 1993. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharm 241:1-6.

Aytemir K, et al. 2000. Assessment of autonomic nervous system functions in patients with vitamin B12 deficiency by power spectral analysis of heart rate variability. Pacing Clin Electrophysiol 23:975-78.

Baik HW, et al. 1999. Vitamin B12 deficiency in the elderly. Annu Rev Nutr 19:357-77.

Eastley R, et al. 2000. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropshychological function. Int J Geriatr Psychiatry 15:226-33.

Fenech M. 1999. Micronucleus frequency in human lymphocytes is related to plasma vitamin B12 and homocysteine. Muta Res 428:299-304.

Freeman AG. 1992. Cyanocobalamin–a case for withdrawal: discussion paper. J Royal Soc Med 85:686-7.

Haddad EH, et al. 1999. Dietary intake and biochemical, hematologic and immune status of vegans compared with nonvegetarians. Am J Clin Nutr 70(3 suppl):586S-93S.

Kaptan K, et al. 2000. Helicobacter pylori–is it a novel causative agent in vitamin B12 deficiency? Arch Intern Med 160(9):1349-53.

Kikuchi M, et al. 1997. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthal Vis Sci 38:848-54.

Kuwabara S, et al. 1999. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 38:472-5.

Laine L, et al. 2000. Review article: potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther 14:651-68.

Lederle FA. Oral cobalamin for pernicious anemia: back from the verge of extinction. J Am Geratr Soc 46:1125-27.

Lindeman RD, et al. 2000. Serum vitamin B12, C and folate concentrations in the New Mexico elder health surve: correlations with cognitive and affective functions. J Am Coll Nutr 19:68-76.

Mayer G, et al. 1996. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharm 15:456-64.

Meins W, et al. 2000. Subnormal serum vitamin B12 and behavioural and psychological symptoms in Alzheimer’s disease. Int J Geriatr Psychiatry 15:415-18.

Moelby L, et al. 2000. Relationahip between methylmalonic acid and cobalamin in uremia. Kindey Int 57:265-73.

Pongstaporn W, et al. 1999. Hematological parameters, ferritin and vitamin B12 in vegetarians. J Med Assoc Thai 82:304-11.

Silver H. 2000. Vitamin B12 levels are low in hospitalized psychiatric patients. Isr J Psychiatry Relat Sci 37:41-45.

Sponne IE, et al. 2000. Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency. Neurosci Lett 288:191-4.

Tamura J, et al. 1999. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 116:28-32.

Temple ME, et al. 2000. Homocysteine as a risk factor for atherosclerosis. Ann Pharmacother 34:57-65.

Watanabe T, et al. 1994. Ultra-high dose methylcogalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 122:140-43.

Yagihashi S, et al. 1982. In vivo effect of methylcobalamin on the periopheral nerve structure in streptozotocin diabetic rats. Horm Metab Res 14:10-13.