Bioenergetic Therapy for Aging
Mitochondria hold the key to cellular life and deathFebruary 2001
When Cellular Energy Declines
Programmed cell death is a well-orchestrated process of cellular self-destruction. As the cell shrinks and then fragments, its organelles remain relatively intact and enclosed by membranes. Neighboring cells or macrophages safely digest the fragments. By contrast, in necrotic cell death the cell swells and ruptures, organelles disintegrate, and inflammation tends to occur.
Figure 3. CoQ10 protects rat liver mitochondria from free radical toxicity.
|Normal mitochondria from the liver of an untreated rat.||Megamitochondria from the liver of a rat given the toxin hydrazine. This remarkable enlargement of the mitochondria often precedes cell death from oxidative stess.||Mitochondria from the liver of a rat given CoQ10 along with the toxin. These mitochondria are nearly normal, exhibiting only slight enlargement.|
Artist's impression, adapted from Adachi K. et al. (1995).
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