Protect your DNA from CT Scans and X-rays
Research Supports Nutrient Shields Against Ionizing RadiationAugust 2010
By Robert Klein
S-adenosylmethionine (SAMe) is a powerful methyl group donor that’s essential for keeping up cellular levels of the vital antioxidant glutathione.79,80 Enzymes vital for DNA repair (and hence cancer protection) can’t function properly in the absence of methyl donors such as SAMe.81 In early 2010 we learned that ionizing radiation actually suppresses SAMe levels in animal models.82 Increasing the animals’ SAMe levels, on the other hand, minimized DNA damage from ionizing radiation.82
Vitamins and Trace Minerals
The “ACE” vitamins (A, C, and E) offer proven antioxidant protection as a result of their molecular structures. High intakes of these vitamins and other antioxidants protect airline pilots from radiation-induced chromosomal damage,83 an occupational hazard in those who work at high altitudes. In fact, ACE supplements have been proposed as “space foods” to protect astronauts from high radiation levels.84
Beta-carotene, the precursor of vitamin A was first used clinically in the wake of the Chernobyl nuclear accident in treatment of children from the region. Supplementation reduced the amount of radiation-induced oxidized lipids.85 More controlled animal studies showed that vitamin A could reverse radiation-induced gene expression abnormalities that could lead to cancer.86-88 Other studies show that vitamin A ameliorates other radiation effects and enhances death of cancerous cells.89 Still other studies reveal that vitamin A can actually prevent radiation-induced death of healthy cells.90
Vitamin C, together with natural antioxidant systems such as glutathione, helps protect DNA and chromosomes from oxidative damage.91-93 Vitamin C also inhibits radiation-induced death of human blood cells.94 Remarkably, vitamin C can counteract radiation-induced “long-lived radicals” (LLRs) that destabilize chromosomes and induce cancerous mutations.95 The ability to counter both classical radicals and LLRs may be vital in preventing genetic damage from radiation.95
Like vitamin C, vitamin E stabilizes free radicals once they form, reducing their toxicity, an effect vital in radioprotection.7 Importantly, vitamin E enhances the growth-inhibiting effect of radiation on cancer tissue while simultaneously protecting normal cells.96 Animal studies show that vitamin E significantly protects mice from dying after exposure to otherwise lethal levels of gamma rays.97 Intriguingly, this effect is the result of modulation of cytokines; it is accompanied by valuable increases in new blood cell formation suppressed by radiation.97,98
A remarkable study among X-ray technicians reveals just how powerful antioxidant vitamins can be. Radiology techs are nominally protected by elaborate shielding, but they’re still exposed to unnaturally high levels of radiation over the course of a lifetime. As a result they tend to have higher levels of tissue oxidation. But when a group of techs was supplemented with vitamins C (500 mg) and E (150 mg) daily for 15 weeks, their markers of tissue oxidation plummeted, and their levels of natural antioxidants (such as glutathione in red blood cells) rose significantly.99
Our endogenous antioxidant systems such as superoxide dismutase, catalase, and glutathione peroxidase all depend on trace minerals as cofactors for their function. That makes those minerals, especially zinc and manganese, vitally important for sustaining whole-body resistance to ionizing radiation. Zinc supplements protected rats from oxidant damage to their red blood cells induced by radioactive iodine.100,101 And a zinc supplement protected bone marrow, but not tumor cells, from radiation-induced damage.102 Since mitochondria produce huge amounts of free radicals, they are especially susceptible to radiation damage. Both zinc and manganese provide powerful mitochondria-specific radioprotection in animal studies.103
Other Potent Radioprotective Nutrients
As we’ve noted, most nutrients with powerful antioxidant activity can be expected to help protect us against radiation exposure from CT scans.104 In addition to those we’ve discussed, there’s good evidence for radioprotection by spirulina extracts, which protect bone marrow cells from DNA damage.105 Melatonin also protects dividing cells and circulating blood cells from chromosomal injury by radiation.106,107 Licorice extracts block DNA damage and protect lipids from radiation-induced peroxidation.108 The Indian gooseberry (Emblica officianalis) increases survival time and reduces mortality of mice exposed to whole-body radiation.109 Effects include protection against lipid peroxidation and protection of rapidly-dividing cells in the intestine.110 Carnosic acid and other rosemary extracts protect against DNA damage through their antioxidant activity, both before and after radiation exposure.111
Summary and Suggestions
Radiation from “routine” diagnostic studies, especially CT scans, poses a substantial and largely unrecognized threat to our health. But radiation damage primarily stems from free radical formation. That means we can protect ourselves powerfully with antioxidant nutrients. Naturally, you should already be using a comprehensive antioxidant regimen for health maintenance. But should you find yourself (or a loved one) in line for a CT scan, X-ray, or other high-radiation procedures, consider the following suggestions as soon as you learn you’ll undergo the test:
No one wants to take unnecessary risks with their health—ask your doctor if a planned test is truly the only way to get desired diagnostic information. But these steps can offer significant protection in the event that such a study is truly unavoidable.
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.
1. Semelka RC, Armao DM, Elias J, Jr., Huda W. Imaging strategies to reduce the risk of radiation in CT studies, including selective substitution with MRI. J Magn Reson Imaging. 2007 May;25(5):900-9.
2. Berrington de Gonzalez A, Mahesh M, Kim KP, et al. Projected cancer risks from computed tomographic scans performed in the United States in 2007. Arch Intern Med. 2009 Dec 14;169(22):2071-7.
3. Brenner D, Elliston C, Hall E, Berdon W. Estimated risks of radiation-induced fatal cancer from pediatric CT. AJR Am J Roentgenol. 2001 Feb;176(2):289-96.
4. Available at: http://www.usatoday.com/news/health/2010-04-28-chestct28_ST_N.htm. Accessed May 7, 2010.
5. Available at: http://www.bendbulletin.com/apps/pbcs.dll/article?AID=/20091029/NEWS0107/910290309/-1/RSSNEWSMAP. Accessed January 12, 2010.
6. Bogdanich W. Radiation overdoses point up dangers of CT scans. The New York Times. October 15, 2009.
7. Gould P. Radiation overdose in 200 patients leads to FDA safety notice. BMJ. 2009;339:b4217.
8. Kuehn BM. FDA warning: CT scans exceeded proper doses. JAMA. 2010 Jan 13;303(2):124.
9. Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol. 1994 Jan;65(1):27-33.
10. Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002 Oct;18(10):872-9.
11. Weiss JF, Landauer MR. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology. 2003 Jul 15;189(1-2):1-20.
12. Okunieff P, Swarts S, Keng P, et al. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol. 2008;614:165-78.
13. Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML. Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes. Mutat Res. 1998 Feb 2;397(2):203-8.
14. Annabi B, Lee YT, Martel C, Pilorget A, Bahary JP, Beliveau R. Radiation induced-tubulogenesis in endothelial cells is antagonized by the antiangiogenic properties of green tea polyphenol (-) epigallocatechin-3-gallate. Cancer Biol Ther. 2003 Nov-Dec;2(6):642-15.
15. Bickenbach KA, Veerapong J, Shao MY, et al. Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy. Cancer Gene Ther. 2008 Mar;15(3):133-9.
16. Bader Y, Getoff N. Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation. Anticancer Res. 2006 Nov-Dec;26(6B):4403-8.
17. Baatout S, Derradji H, Jacquet P, Ooms D, Michaux A, Mergeay M. Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol. Int J Mol Med. 2004 Jun;13(6):895-902.
18. Reagan-Shaw S, Mukhtar H, Ahmad N. Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells. Photochem Photobiol. 2008 Mar-Apr;84(2):415-21.
19. Carsten RE, Bachand AM, Bailey SM, Ullrich RL. Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells. Radiat Res. 2008 Jun;169(6):633-8.
20. Velioglu-Ogunc A, Sehirli O, Toklu HZ, et al. Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity. Free Radic Res. 2009 Aug 25:1-12.
21. Chawla R, Arora R, Sagar RK, et al. 3-O-beta-D-Galactopyranoside of quercetin as an active principle from high altitude Podophyllum hexandrum and evaluation of its radioprotective properties. Z Naturforsch C. 2005 Sep-Oct;60(9-10):728-38.
22. Shukla SK, Chaudhary P, Kumar IP, et al. Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. Environ Mol Mutagen. 2006 Dec;47(9):647-56.
23. Devipriya N, Sudheer AR, Srinivasan M, Menon VP. Quercetin ameliorates gamma radiation-induced DNA damage and biochemical changes in human peripheral blood lymphocytes. Mutat Res. 2008 Jun 30;654(1):1-7.
24. Uchida S, Ozaki M, Suzuki K, Shikita M. Radioprotective effects of (-)-epigallocatechin 3-O-gallate (green-tea tannin) in mice. Life Sci. 1992;50(2):147-52.
25. Kim SH, Kim SR, Lee HJ, et al. Apoptosis in growing hair follicles following gamma-irradiation and application for the evaluation of radioprotective agents. In Vivo. 2003 Mar-Apr;17(2):211-4.
26. Lee HJ, Kim JS, Moon C, et al. Modification of gamma-radiation response in mice by green tea polyphenols. Phytother Res. 2008 Oct;22(10):1380-3.
27. Landauer MR, Srinivasan V, Seed TM. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol. 2003 Nov-Dec;23(6):379-85.
28. Zavodnik LB. Isoflavone genistein-8-c-glycoside prevents the oxidative damages in structure and function of rat liver microsomal membranes. Radiats Biol Radioecol. 2003 Jul-Aug;43(4):432-8.
29. Zhou Y, Mi MT. Genistein stimulates hematopoiesis and increases survival in irradiated mice. J Radiat Res (Tokyo). 2005 Dec;46(4):425-33.
30. Davis TA, Clarke TK, Mog SR, Landauer MR. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol. 2007 Mar;83(3):141-51.
31. Singh VK, Grace MB, Parekh VI, Whitnall MH, Landauer MR. Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice. Int Immunopharmacol. 2009 Nov;9(12):1401-10.
32. Dittmann K, Loffler H, Bamberg M, Rodemann HP. Bowman-Birk proteinase inhibitor (BBI) modulates radiosensitivity and radiation-induced differentiation of human fibroblasts in culture. Radiother Oncol. 1995 Feb;34(2):137-43.
33. Dittmann KH, Gueven N, Mayer C, Rodemann HP. The radioprotective effect of BBI is associated with the activation of DNA repair-relevant genes. Int J Radiat Biol. 1998 Aug;74(2):225-30.
34. Dittmann K, Mayer C, Kehlbach R, Rodemann HP. The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport. Radiother Oncol. 2008 Mar;86(3):375-82.
35. Gueven N, Dittmann K, Mayer C, Rodemann HP. Bowman-Birk protease inhibitor reduces the radiation-induced activation of the EGF receptor and induces tyrosine phosphatase activity. Int J Radiat Biol. 1998 Feb;73(2):157-62.
36. Dittmann KH, Dikomey E, Mayer C, Rodemann HP. The Bowman-Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation-treated nucleotide excision repair-competent cells but not of xeroderma pigmentosum cells. Int J Radiat Biol. 2000 Feb;76(2):223-9.
37. Dittmann KH, Mayer C, Rodemann HP. Radioprotection of normal tissue to improve radiotherapy: the effect of the Bowman Birk protease inhibitor. Curr Med Chem Anticancer Agents. 2003 Sep;3(5):360-3.
38. Friedman M, Brandon DL. Nutritional and health benefits of soy proteins. J Agric Food Chem. 2001 Mar;49(3):1069-86.
39. Losso JN. The biochemical and functional food properties of the bowman-birk inhibitor. Crit Rev Food Sci Nutr. 2008 Jan;48(1):94-118.
40. Choudhary D, Chandra D, Kale RK. Modulation of radioresponse of glyoxalase system by curcumin. J Ethnopharmacol. 1999 Jan;64(1):1-7.
41. Inano H, Onoda M. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2’-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. Int J Radiat Oncol Biol Phys. 2002 Jul 1;53(3):735-43.
42. Srinivasan M, Rajendra Prasad N, Menon VP. Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutat Res. 2006 Dec 10;611(1-2):96-103.
43. Jagetia GC. Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol. 2007;595:301-20.
44. Lee JC, Kinniry PA, Arguiri E, et al. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res. 2010 May;173(5):590-601.
45. Herman-Antosiewicz A, Powolny AA, Singh SV. Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacol Sin. 2007 Sep;28(9):1355-64.
46. Singh SP, Abraham SK, Kesavan PC. In vivo radioprotection with garlic extract. Mutat Res. 1995 Dec;345(3-4):147-53.
47. Singh SP, Abraham SK, Kesavan PC. Radioprotection of mice following garlic pretreatment. Br J Cancer Suppl. 1996 Jul;27:S102-4.
48. Lee EK, Chung SW, Kim JY, et al. Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-kappaB Signaling in C57/BL6 Mouse Kidney. J Med Food. 2009 Jun;12(3):542-51.
49. Jagetia GC, Baliga MS, Venkatesh P, Ulloor JN. Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat Res. 2003 Nov;160(5):584-92.
50. Jagetia G, Baliga M, Venkatesh P. Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action. Cancer Biother Radiopharm. 2004 Aug;19(4):422-35.
51. Sharma A, Haksar A, Chawla R, et al. Zingiber officinale Rosc. modulates gamma radiation-induced conditioned taste aversion. Pharmacol Biochem Behav. 2005 Aug;81(4):864-70.
52. Haksar A, Sharma A, Chawla R, et al. Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner. Pharmacol Biochem Behav. 2006 Jun;84(2):179-88.
53. Emerit I, Arutyunyan R, Oganesian N, et al. Radiation-induced clastogenic factors: anticlastogenic effect of Ginkgo biloba extract. Free Radic Biol Med. 1995 Jun;18(6):985-91.
54. Alaoui-Youssefi A, Lamproglou I, Drieu K, Emerit I. Anticlastogenic effects of Ginkgo biloba extract (EGb 761) and some of its constituents in irradiated rats. Mutat Res. 1999 Sep 15;445(1):99-104.
55. Emerit I, Oganesian N, Sarkisian T, et al. Clastogenic factors in the plasma of Chernobyl accident recovery workers: anticlastogenic effect of Ginkgo biloba extract. Radiat Res. 1995 Nov;144(2):198-205.
56. Sener G, Kabasakal L, Atasoy BM, et al. Ginkgo biloba extract protects against ionizing radiation-induced oxidative organ damage in rats. Pharmacol Res. 2006 Mar;53(3):241-52.
57. Dardano A, Ballardin M, Ferdeghini M, et al. Anticlastogenic effect of Ginkgo biloba extract in Graves’ disease patients receiving radioiodine therapy. J Clin Endocrinol Metab. 2007 Nov;92(11):4286-9.
58. Kumar M, Sharma MK, Saxena PS, Kumar A. Radioprotective effect of Panax ginseng on the phosphatases and lipid peroxidation level in testes of Swiss albino mice. Biol Pharm Bull. 2003 Mar;26(3):308-12.
59. Takeda A, Katoh N, Yonezawa M. Restoration of radiation injury by ginseng. III. Radioprotective effect of thermostable fraction of ginseng extract on mice, rats and guinea pigs. J Radiat Res (Tokyo). 1982 Jun;23(2):150-67.
60. Kim SH, Cho CK, Yoo SY, Koh KH, Yun HG, Kim TH. In vivo radioprotective activity of Panax ginseng and diethyldithiocarbamate. In Vivo. 1993 Sep-Oct;7(5):467-70.
61. Kim TH, Lee YS, Cho CK, Park S, Choi SY, Yool SY. Protective effect of ginseng on radiation-induced DNA double strand breaks and repair in murine lymphocytes. Cancer Biother Radiopharm. 1996 Aug;11(4):267-72.
62. Lee TK, Allison RR, O’Brien KF, et al. Ginseng reduces the micronuclei yield in lymphocytes after irradiation. Mutat Res. 2004 Jan 10;557(1):75-84.
63. Kim SH, Jeong KS, Ryu SY, Kim TH. Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice. In Vivo. 1998 Mar-Apr;12(2):219-22.
64. Kim SH, Son CH, Nah SY, Jo SK, Jang JS, Shin DH. Modification of radiation response in mice by Panax ginseng and diethyldithiocarbamate. In Vivo. 2001 Sep-Oct;15(5):407-11.
65. Song JY, Han SK, Bae KG, et al. Radioprotective effects of ginsan, an immunomodulator. Radiat Res. 2003 Jun;159(6):768-74.
66. Lee TK, Johnke RM, Allison RR, O’Brien KF, Dobbs LJ, Jr. Radioprotective potential of ginseng. Mutagenesis. 2005 Jul;20(4):237-43.
67. Lee TK, O’Brien KF, Wang W, et al. Radioprotective effect of American ginseng on human lymphocytes at 90 minutes postirradiation: a study of 40 cases. J Altern Complement Med. 2010 May;16(5):561-7.
68. Kozurkova M, Hakova H, Misurova E. The effect of silymarin, a hepatoprotective substance, on liver histones in irradiated rats. Vet Med (Praha). 1994;39(2-3):85-92.
69. Kropacova K, Misurova E, Hakova H. Protective and therapeutic effect of silymarin on the development of latent liver damage. Radiats Biol Radioecol. 1998 May-Jun;38(3):411-5.
70. Tiwari P, Kumar A, Ali M, Mishra KP. Radioprotection of plasmid and cellular DNA and Swiss mice by silibinin. Mutat Res. 2010 Jan;695(1-2):55-60.
71. Ramadan LA, Roushdy HM, Abu Senna GM, Amin NE, El-Deshw OA. Radioprotective effect of silymarin against radiation induced hepatotoxicity. Pharmacol Res. 2002 Jun;45(6):447-54.
72. Selig C, Nothdurft W, Fliedner TM. Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow. J Cancer Res Clin Oncol. 1993;119(6):346-9.
73. Liu Y, Zhang H, Zhang L, et al. Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice. Eur J Pharmacol. 2007 Dec 1;575(1-3):142-8.
74. Kilciksiz S, Demirel C, Erdal N, et al. The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model. Acta Med Okayama. 2008 Dec;62(6):403-9.
75. Baier JE, Neumann HA, Moeller T, Kissler M, Borchardt D, Ricken D. Radiation protection through cytokine release by N-acetylcysteine. Strahlenther Onkol. 1996 Feb;172(2):91-8.
76. Demirel C, Kilciksiz S, Ay OI, Gurgul S, Ay ME, Erdal N. Effect of N-acetylcysteine on radiation-induced genotoxicity and cytotoxicity in rat bone marrow. J Radiat Res (Tokyo). 2009 Jan;50(1):43-50.
77. Tiwari P, Kumar A, Balakrishnan S, Kushwaha HS, Mishra KP. Radiation-induced micronucleus formation and DNA damage in human lymphocytes and their prevention by antioxidant thiols. Mutat Res. 2009 May 31;676(1-2):62-8.
78. Wambi C, Sanzari J, Wan XS, et al. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat Res. 2008 Apr;169(4):384-96.
79. Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243-9.
80. Lu SC. S-Adenosylmethionine. Int J Biochem Cell Biol. 2000 Apr;32(4):391-5
81. Batra V, Mishra KP. Modulation of DNA methyltransferase profile by methyl donor starvation followed by gamma irradiation. Mol Cell Biochem. 2007 Jan;294(1-2):181-7.
82. Batra V, Sridhar S, Devasagayam TP. Enhanced one-carbon flux towards DNA methylation: Effect of dietary methyl supplements against gamma-radiation-induced epigenetic modifications. Chem Biol Interact. 2010 Feb 12;183(3):425-33.
83. Yong LC, Petersen MR, Sigurdson AJ, Sampson LA, Ward EM. High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots. Am J Clin Nutr. 2009 Nov;90(5):1402-10.
84. Chen B, Zhou XC. Protective effect of natural dietary antioxidants on space radiation-induced damages. Space Med Med Eng (Beijing). 2003;16 Suppl:514-8.
85. Ben-Amotz A, Yatziv S, Sela M, et al. Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiat Environ Biophys. 1998 Oct;37(3):187-93.
86. Burns FJ, Chen S, Xu G, Wu F, Tang MS. The action of a dietary retinoid on gene expression and cancer induction in electron-irradiated rat skin. J Radiat Res (Tokyo). 2002 Dec;43 Suppl:S229-32.
87. Nubel T, Dippold W, Kaina B, Fritz G. Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid. Carcinogenesis. 2004 Aug;25(8):1335-44.
88. Zhang R, Burns FJ, Chen H, Chen S, Wu F. Alterations in gene expression in rat skin exposed to 56Fe ions and dietary vitamin A acetate. Radiat Res. 2006 May;165(5):570-81.
89. Marekova M, Vavrova J, Vokurkova D, Psutka J. Modulation of ionizing radiation-induced apoptosis and cell cycle arrest by all-trans retinoic acid in promyelocytic leukemia cells (HL-60). Physiol Res. 2003;52(5):599-606.
90. Vorotnikova E, Tries M, Braunhut S. Retinoids and TIMP1 prevent radiation-induced apoptosis of capillary endothelial cells. Radiat Res. 2004 Feb;161(2):174-84.
91. Lenton KJ, Therriault H, Fulop T, Payette H, Wagner JR. Glutathione and ascorbate are negatively correlated with oxidative DNA damage in human lymphocytes. Carcinogenesis. 1999 Apr;20(4):607-13.
92. Konopacka M, Rzeszowska-Wolny J. Antioxidant vitamins C, E and beta-carotene reduce DNA damage before as well as after gamma-ray irradiation of human lymphocytes in vitro. Mutat Res. 2001 Apr 5;491(1-2):1-7.
93. Konopacka M, Palyvoda O, Rzeszowska-Wolny J. Inhibitory effect of ascorbic acid post-treatment on radiation-induced chromosomal damage in human lymphocytes in vitro. Teratog Carcinog Mutagen. 2002;22(6):443-50.
94. Witenberg B, Kletter Y, Kalir HH, et al. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiat Res. 1999 Nov;152(5):468-78.
95. Waldren CA, Vannais DB, Ueno AM. A role for long-lived radicals (LLR) in radiation-induced mutation and persistent chromosomal instability: counteraction by ascorbate and RibCys but not DMSO. Mutat Res. 2004 Jul 13;551(1-2):255-65.
96. Prasad KN, Kumar B, Yan XD, Hanson AJ, Cole WC. Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. J Am Coll Nutr. 2003 Apr;22(2):108-17.
97. Singh VK, Shafran RL, Jackson WE 3rd, Seed TM, Kumar KS. Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol. 2006 Aug;81(1):55-61.
98. Singh VK, Brown DS, Kao TC. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor. Int J Radiat Biol. 2010 Jan;86(1):12-21.
99. Kayan M, Naziroglu M, Celik O, Yalman K, Koylu H. Vitamin C and E combination modulates oxidative stress induced by X-ray in blood of smoker and nonsmoker radiology technicians. Cell Biochem Funct. 2009 Oct;27(7):424-9.
100. Dani V, Dhawan DK. Radioprotective role of zinc following single dose radioiodine (131I) exposure to red blood cells of rats. Indian J Med Res. 2005 Oct;122(4):338-42.
101. Dani V, Dhawan D. Zinc as an antiperoxidative agent following iodine-131 induced changes on the antioxidant system and on the morphology of red blood cells in rats. Hell J Nucl Med. 2006 Jan-Apr;9(1):22-6.
102. Floersheim GL, Chiodetti N, Bieri A. Differential radioprotection of bone marrow and tumour cells by zinc aspartate. Br J Radiol. 1988 Jun;61(726):501-8.
103. Epperly MW, Gretton JE, Sikora CA, et al. Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiat Res. 2003 Nov;160(5):568-78.
104. Alcaraz M, Acevedo C, Castillo J, et al. Liposoluble antioxidants provide an effective radioprotective barrier. Br J Radiol. 2009 Jul;82(979):605-9.
105. Qishen P, Guo BJ, Kolman A. Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test. Toxicol Lett. 1989 Aug;48(2):165-9.
106. Badr FM, El Habit OH, Harraz MM. Radioprotective effect of melatonin assessed by measuring chromosomal damage in mitotic and meiotic cells. Mutat Res. 1999 Aug 18;444(2):367-72.
107. Koc M, Buyukokuroglu ME, Taysi S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol Pharm Bull. 2002 May;25(5):656-7.
108. Shetty TK, Satav JG, Nair CK. Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation. Phytother Res. 2002 Sep;16(6):576-8.
109. Singh I, Sharma A, Nunia V, Goyal PK. Radioprotection of Swiss albino mice by Emblica officinalis. Phytother Res. 2005 May;19(5):444-6.
110. Jindal A, Soyal D, Sharma A, Goyal PK. Protective effect of an extract of Emblica officinalis against radiation-induced damage in mice. Integr Cancer Ther. 2009 Mar;8(1):98-105.
111. Del Bano MJ, Castillo J, Benavente-Garcia O, et al. Radioprotective-antimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by gamma-rays. J Agric Food Chem. 2006 Mar 22;54(6):2064-8.9.