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Suzanne Somers’s Quest to Educate the World About How to Delay Aging

June 2012

Aging Factor 8: Fatty Acid Imbalance

Aging distorts the metabolism of essential fatty acids, throwing their delicate proportion and interplay off balance. The resulting fatty acid imbalance may manifest as anything from irregular heartbeat and skin disorders to heart disease, high blood pressure, and stroke.

Solution: Fatty Acid Intervention

Nutrient Typical Daily Dose
Fish oil 1,400 mg EPA and 1,000 mg DHA
Gamma-linolenic acid 300-600 mg
Lecithin granules 10 grams

Aging Factor 9: DNA Mutation

We are continuously exposed to synthetic and natural carcinogens in our food supply, in everyday household products, and in our environment. Cooking any food at high temperatures (above 250 degrees Fahrenheit) also generates toxic cancer-causing agents. These environmental and dietary compounds mutate cellular DNA.

Aging cells gradually lose their ability to repair DNA from these constant assaults. The resulting DNA damage can cause normally functioning cells to proliferate out of control, turning them into cancer cells.

These processes can be halted and reversed with a number of plant-based compounds that break down carcinogens, prevent cells from becoming cancerous, and disable mutated cells.

Solution: Targeted DNA Protection and Repair

Nutrient Typical Daily Dose
Chlorophyllin 100-300 mg
Curcumin* 400-800 mg daily
Broccoli extract 400-800 mg
Watercress extract 50-100 mg
Rosemary extract 50-100 mg
Apigenin 25-50 mg

Aging Factor 10 : Immune Dysfunction

As the aging immune system loses its ability to attack bacteria, viruses, and cancer cells, it instead generates excessive levels of inflammatory chemicals that turn on its host and create autoimmune diseases such as rheumatoid syndrome.

Solution: Supercharge Your Immune System

You can restore your immune system using a few safe, low-cost compounds that target age-related immune conditions. They enhance different parts of your immune system at the same time to optimize your defenses against infectious disease, including pneumonia, the flu, and other highly infectious diseases.

Nutrient Typical Daily Dose
Vitamin D3 5,000-8,000 IU
DHEA 15-50 mg
Beta 1,3/1,6 glucan 100-600 mg
Probiotic 333 million colony forming units (CFU)
High-potency multinutrient formula Two tablets/capsules
Lactoferrin 300 mg

Aging Factor 11: Enzyme Imbalance

Youthful functions within your cells depend on multiple enzymatic reactions occurring with precise timing. Aging causes enzyme imbalances in the brain and liver. The result can manifest as neurological diseases such as Parkinson’s or persistent memory loss. Impaired liver function results in toxic damage to every cell in the body.

Solution: Restore Youthful Enzyme Cofactors

Nutrient Typical Daily Dose
L-methylfolate 1,000 mcg
S-adenosyl- methionine (SAMe) 200-400 mg
High-potency multinutrient formula Two tablets/capsules

Aging Factor 12: Loss of Mitochondria

The increasing weakness and fatigue we inevitably experience as we get older isn’t only the result of a steady age-related decline in the amount of energy our mitochondria can produce. The number of healthy mitochondria throughout our bodies declines sharply as well.

Solution: Stimulate Growth of New Mitochondria

Mitochondrial biogenesis is the scientific term for the process of growing fresh mitochondria. The most recent research indicates that the following nutrients listed can trigger mitochondrial biogenesis and increase mitochondrial energy output.

Nutrient Typical Daily Dose
Pyrroloquinoline quinone (PQQ) 10-20 mg
CoQ10 100-200 mg
R-lipoic acid 300-600 mg
Trans-resveratrol 250 mg
Acetyl-L-carnitine 1,000-2,000 mg

Aging Factor 13: Excitotoxicity

Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate. The result is brain cell damage and destruction leading to neurological disorders. Excitotoxicity contributes to lasting brain damage that arises from events like stroke and traumatic brain injury.

Solution: Compounds That Protect Against Glutamate Injury

There are nutrients that can protect brain cells and neurons from excitotoxicity injury and regenerate damaged cells.

Nutrient Typical Daily Dose
Vinpocetine 15-30 mg
B12 1 mg
Magnesium threonate 1,000-2,000 mg
Blueberry extract 500-2,000 mg
Melatonin 1-10 mg before bed
Carnosine 1,000 mg

Aging Factor 14: Circulatory Deficit

Delivery of nutrient- and oxygen-rich blood to the brain, heart, and extremities is impaired as a part of normal aging. Major strokes and ministrokes are common problems associated with circulatory deficit to the brain. The skin of all aged people shows the effects of lack of nutrient-rich blood to the upper layers. An underlying cause of circulatory deficits is endothelial dysfunction, which destroys the inner lining of blood vessels and decimates their ability to efficiently trans- port blood.

Solution: Multimodal Support for Healthy Circulation

With all the mainstream medical and media attention focus on cholesterol and high blood pressure for heart health, a major issue facing most maturing people has been overlooked: healthy circulation.

Anywhere from two-thirds to three-fourths of Americans are concerned about circulatory issues by some estimates. Ruptured blood vessels, embolism, stroke, and varicose veins affect many people. Many resort to blood-thinning medications with potentially dangerous side effects. Most have been kept in the dark about low-cost, natural alternatives.

One of the most exciting is a brand-new, cutting-edge, high-potency tomato extract. This tomato extract is specially processed in such a way that provides benefits you cannot obtain by consuming cooked tomato products. In human clinical trials, it’s proven to be completely safe with no side effects. Just three grams improves blood flow within ninety minutes and lasts for more than twelve hours!

It’s already been approved in Europe for clinical use. It works by helping improve the balance of clotting factors—platelets—in your bloodstream. Even more exciting, it worked for 97 percent of test subjects, which means it will most likely work for you, without the risk of hemorrhaging, organ damage, and other side effects associated with blood-thinning drugs.

To protect against endothelial dysfunction, a critically important nutrient is pomegranate. In human clinical studies, those who drank pomegranate juice along with taking their standard therapy are able to reverse markers of circulatory deficit. In one study, circulation to the brain increased by 30 percent after one year in the pomegranate group, compared to reduced circulation to the brain in the placebo group not getting pomegranate. Both groups continued with their standard therapies.

Nutrient Typical Daily Dose
Tomato extract 3 grams
Pomegranate extract 500 mg
Fish oil 1,400 mg EPA and 1,000 mg DHA
Sweet orange extract 600 mg
Vinpocetine 10-30 mg

Aging Factor 15: Loss of Youthful Gene Expression

In response to normal aging and environmental toxins, changes occur in genes required to sustain youthful cellular function. What happens is that genes that maintain cellular health slowly “turn off,” while genes that make us vulnerable to degenerative pathologies become overexpressed (turned on). As cells lose their youthful gene expression profile, we succumb to a plethora of discomforts, diseases, and eventual death.

Solution: Activate Your Longevity Genes

Longevity researchers have known for seventy-five years that consuming far fewer calories while meeting all nutritional needs can greatly increase life span in some species. More recently, geneticists discovered why: caloric restriction activates genes that slow cell aging.

In 2003, remarkable news arrived from the scientific community that a compound found in red grapes and other plants called resveratrol extended the life span of certain cells by as much as 70 percent. Even more exciting were findings in 2006 from a team of Harvard researchers showing that resveratrol “switches on” many of the same genes as caloric restriction!

Today this remarkable compound has attained celebrity status, with nationally known doctors endorsing its use. Medical researchers have found it combats not only aging but also the diseases of aging.

Further research into the area of youthful gene expression has brought to light a new class of compounds like resveratrol that enables aging cells to reverse course and function as though they were young again. These compounds work in synergy with resveratrol, mutually complementing and reinforcing its rejuvenating biological effects.

The following box describes four nutrients that help promote more youthful gene expression. Many of them can be found in multi-ingredient formulations, so you only need to take a few pills each day to obtain these potencies.

Nutrient Typical Daily Dose
Trans-resveratrol 250 mg
Fisetin 48 mg
Trans-pterostilbene 3-100 mg
Vitamin D 5,000 IU

Aging Factor 16: Loss of Insulin Sensitivity

Loss of Insulin Sensitivity

In youth, we efficiently utilize ingested carbohydrates to produce cellular energy with a minimal amount converted

to body fat storage. Aging reduces cellular sensitivity to insulin, which results in most people suffering chronically high blood glucose and insulin. This not only contributes to common age-related disorders but also unfavorably influences gene expression patterns.

Even if a blood test shows fasting glucose levels are normal, too many of us suffer from constant exposure to excess glucose throughout our normal days. In the presence of excess glucose, healthy tissue comes under an incredibly destructive free-radical assault. The ensuing cellular destruction has been linked to everything from blood vessel damage and stroke to cancer.

The bottom line is that most of us are playing with fire when it comes to excess blood sugar. Without knowing it, we place ourselves under a lifelong assault from excess glucose that wreaks havoc on our bodies long before we or our doctors recognize it. This is why some experts call glucose the silent killer. Even modest spikes in blood sugar (fasting glucose above 85 mg/dL) have been linked to increased risk of heart attack.

Solution: Restore Youthful Glucose Control

The good news is that forward-thinking researchers have identified a number of safe, completely natural substances that work in different ways to keep our after-meal blood sugar levels in check.

The most recently discovered of these is green coffee bean extract. I’m going to go into a bit of detail here because it really is exciting.

It works by blocking the destructive elevation in blood sugar that occurs after meals. Researchers have identified the active compound in raw coffee beans that combats excess blood sugar as chlorogenic acid. It brings blood sugar under control by both reducing the release of stored glucose into our bloodstreams and stopping the creation of excess glucose within our bodies.

In a recent clinical trial, just 350 mg three times a day of green coffee bean extract produced a remarkable 35 percent reduction in after-meal glucose spike. After twelve weeks, study participants shed on average almost eleven pounds, with fat loss accounting for 92 percent of the weight.

Nutrient Typical Daily Dose
Green coffee bean extract 350 –1,050 mg
Green tea phytosome 300 mg
Irvingia gabonensis extract 300 mg
Chromium 500 mcg
Cinnamon 175 –350 mg
R-lipoic acid 150 –300 mg

Aging Factor 17: Loss of Bone Density

Aging gradually weakens bones through decalcification and trace mineral loss. A compromised skeletal system negatively affects immune strength, blood cell production, nervous system function, insulin sensitivity, energy metabolism, and weight management.

Solution: Broad-Spectrum Bone Support

Ninety-nine percent of the calcium in our bodies resides in our teeth and bones. It stands to reason that if our bones and teeth store so much calcium, we would need to obtain additional calcium to preserve their strength. The real controversy is why mainstream doctors remain unenlightened about the need of maturing people to take the right kind of calcium supplement—and the proper nutrients to support it.

Broad-Spectrum Bone Support

Ideal forms of calcium to look for on labels are dicalcium malate, calcium bisglycinate, or calcium citrate. They’re easily tolerated by the body, highly absorbable, and supportive of bone mineral density—the key measure of a calcium supplement’s value.

A daily dose of at least 1,000 mg is recommended for female adults. Women can take up to 1,200 mg. You won’t get any additional benefit from high doses. (Men only need around 800 mg a day of supplemen- tal calcium.)

Your body can’t readily absorb calcium without vitamin D3. This vitamin also ensures calcium deposits properly in bone tissue. There are receptors for vitamin D3 in more than thirty different tissue types throughout the body. D3 binds with them to promote immune function, reduce inflammation, reduce hardening of the arteries, enhance heart function, improve brain and nerve tissue performance, and even prevent cancer.

It’s a good idea to have your vitamin D blood levels checked to make sure you’re getting enough. The current evidence suggests that your readings for 25-hydroxy-vitamin-D should be between 50 and 80 ng/ mL in blood for optimal health. Experts suggest taking at least 2,000 IU per day, with most people requiring 5,000 IU per day, to achieve blood levels in a healthy range.

Nutrient Typical Daily Dose
Calcium 1,200 mg
Vitamin D 1,000 IU
Magnesium 340 mg
Zinc 2 mg
Manganese 1 mg
Silicon 5 mg
Boron 3 mg
Vitamin K1 1,000 mcg
Vitamin K2 as MK-4* 1,000 mcg
Vitamin K2 as MK-7 100 mcg

* If you’re taking anticoagulant drugs like Coumadin (warfarin), talk to your doctor before starting on a vitamin K2 regimen.

Aging Factor 18: Oxidative Stress

Free radicals are fiery unstable molecules that have been implicated in most diseases associated with aging.

At the molecular level, the continuous chemical reactions keeping your heart beating, your blood moving, and your brain working look like controlled infernos. The constant exchange of electrons wheeling inside the tiny energy-producing powerhouses in your cells called the mitochondria throws off enormous quantities of energy.

The problem is that as we get older, the cellular structures that once kept these fires under control begin to degrade, including the mitochondria themselves. Aging causes our cells to lose control over these reactions and renders them more vulnerable to destruction.

Solution: Quench the Raging Fires Within

Antioxidants have become popular supplements to protect against free-radical-induced cell damage, but few people take the proper combination of antioxidant supplements to adequately compensate for age-induced loss of endogenous antioxidants such as SOD, glutathione, and catalase.

Nutrient Typical Daily Dose
Superoxide dismutase/ Gliadin complex (GliSODin®) 500 mg
Pomegranate extract 500 mg
Green tea extract 725 mg
Grapeseed extract 150 mg
S-adenosyl-methionine (SAMe) 200-400 mg
Astaxanthin 5-6 mg
R-lipoic acid 300-600 mg
High-potency multinutrient formula Two capsules
Gamma-tocopherol/ sesame lignans 200 mg gamma-E tocopherol with 20 mg ofstandardized sesame lignans

One Final Note

Children can benefit by taking vitamin supplements, but it is the aging human whose body is depleted of the endogenous antioxidants, hormones, enzymatic repair systems, and other biological chemicals needed to sustain life. What is optional in childhood becomes mandatory as humans enter middle age and become vulnerable to a host of degenerative diseases that await them if they fail to protect themselves.

The encouraging news is that supplements like fish oil, vitamin D, lipoic acid, curcumin, CoQ10, resveratrol, DHEA, vitamin K, and SAMe function to circumvent multiple aging factors that conspire to rob us of our youthful health. This means that you don’t have to take gobs of pills to counteract the multiple mechanisms of aging described in this chapter.

Bombshell by Suzanne Somers

Adapted from BOMBSHELL by Suzanne Somers. Copyright © 2012. Published by Crown Archetype, a division of Random House, Inc.

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