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The Truth About Male and Female Sexual Dysfunction

October 2013

By Michael Downey

Potent Formula Reverses Female Sexual Dysfunction

Potent Formula Reverses Female Sexual Dysfunction  

We don’t hear much about female sexual dysfunction—mainly because there are limited guidelines pertaining to the diagnosis and treatment of the condition.56 In reality, loss of libido and other forms of sexual dysfunction plague more women than men—and sadly, 40% of affected women do not seek help from a physician.57 It wouldn’t help much if they did, because mainstream doctors have limited protocol options (other than possibly hormone replacement) for this common condition.56

Female sexual dysfunction involves the disruption of multiple physiological mechanisms—and modern medicine has no consistently safe and effective treatment that targets these various, underlying pathways.

It’s important to note the difference between disinterest and dysfunction. Preferring at times not to engage in sexual activity does not indicate a woman has female sexual dysfunction. Disinterest, or even occasional dysfunction, can be a normal response to a variety of life situations. However, many women are frustrated and depressed by complaints that include decreased libido (low desire or arousal), anorgasmia (inability to achieve orgasm), dyspareunia (painful intercourse),and urogenital atrophy (vaginal itching, soreness, dryness, and pain).58

Fortunately, recent scientific discoveries have found a solution—and it doesn’t involve taking a single prescription drug. Female sexual dysfunction can be traced to six underlying pathways that—if simultaneously regulated—result in a reversal of the full range of symptoms!

Research scientists narrowed down an extensive search of natural plants to three complementary botanical-based compounds:

  • Cordyceps sinensis extract
  • Lepidium meyenii (maca) extract
  • EstroG-100 TM three-extract blend

The combined effects of Cordyceps sinensis and maca modulate all six diverse, underlying biochemical mechanisms—restoring a woman’s normal sexual desire and function.

Also, the blend of three unique extracts known as EstroG-100TM modulates the hormonal activity behind menopausal symptoms—which are frequently the trigger for female sexual dysfunction.

Proven Results in Clinical Trials on Women

Proven Results in Clinical Trials on Women

Cordyceps sinensis

Scientists have found that the active substances in the medicinal mushroom Cordyceps sinensis were able to improve female sexual dysfunction in just 40 days!

In a double-blind, placebo-controlled study, scientists tested the Cs-4 strain of Cordyceps on elderly female patients suffering from sexual dysfunction. The test group took Cordyceps Cs-4 in dosages that translate to 375 milligrams of commercially prepared product (because it is formulated as an 8:1 extract). Up to 86% of the women in the Cs-4 group significantly improved both hyposexuality signs and symptoms—in only 40 days!59

The pharmacologically active substances in extract of Cordyceps sinensis—derived from the Cs-4 strain of this medicinal mushroom—were found to act along 5 of 6 distinct pathways of female sexual dysfunction to:

  • Balance levels of estrogen and testosterone by modulating the hypothalamus-pituitary axis (HPA)59
  • Promote the downstream flow of sex hormones by optimizing adrenal function59,60
  • Increase energy levels and sexual interest by supporting mitochondrial function 59,61
  • Promote normal vaginal lubrication and sexual function by boosting antioxidant action and inhibiting the destruction of nitric oxide, 60,62 and
  • Moderate inflammation by controlling levels of pro-inflammatory cytokines, thus blocking their dampening effect on sexual desire and activity.63,64


Studies show that an extract of Lepidium peruvianum, a high-altitude root plant popularly known as maca , can improve female sexual dysfunction in as little as six weeks!65

In a double-blind, placebo-controlled study, postmenopausal women were given either placebo or powdered maca that translates to 583 to 875 milligrams a day of product (because it is formulated as a 4-6:1 extract).65 Measured on a standard sexual dysfunction scale, the participants who took maca scored more than 34% lower (meaning better) than placebo subjects. They also tested 30% lower (meaning better) on a subscale of anxiety and depression symptoms—a substantial improvement in just six weeks!65

Maca works by providing the optimum balance of nutrients utilized by the body’s neuroendocrine system.66 Evidence shows that this allows maca to regulate 3 of 6 different pathways of female sexual dysfunction—two of those also regulated by Cordyceps plus one other. Maca can:

  • Modulate the hypothalamus-pituitary axis (HPA)65,67
  • Regulate adrenal function,65,68and
  • Optimize levels of brain neurotransmittersin turn reducing the risk of decreased libido, depression, and sexual dysfunction. 65,69


The third compound contains three plant extracts: Phlomis umbrosa, Cynanchum wilfordii, and Angelica gigas Nakai (Korean Angelica).

When blended in correct proportions within a single formulation known as EstroG-100 TM, these extracts naturally and selectively regulate estrogenic activity (enhancing activity in some tissue while inhibiting it in other tissue). This in turn prevents many of the symptoms of menopauseincluding female sexual dysfunction.70

Scientists conducted a double-blind, placebo-controlled study of 64 women with moderate or severe menopausal symptoms. The test group was given 257 milligrams of the EstroG-100™ blend twice daily.

As a result, the average Kupperman Menopausal Index score (a measure of menopausal symptoms) decreased by 62% in the EstroG-100™ group, but only by 19% in the placebo group. And the average vaginal dryness score decreased by 59% in the treatment group versus just 27% among placebo subjects.70

These substantial menopausal and sexual improvements resulted after only 12 weeks—without weight gain or other negative effects! 70

Treat the Sexual Side Effects of Antidepressants
Treat the Sexual Side Effects of Antidepressants

Adverse sexual effects—which can include loss of sexual drive, failure to reach orgasm, and erectile dysfunction—are among the most common negative effects of taking antidepressants.71,72 Men are more often affected by these sexual side effects, but women report more serious sexual symptoms. 72

To offset antidepressant-related sexual dysfunction, doctors often prescribe additional medications.73-75 But these added drugs bring their own adverse reactions76—and some even reverse the mood benefit of the antidepressants!77

Fortunately, a natural extract has been shown to treat sexual dysfunction—in both men and women—when it is a side effect of taking antidepressant drugs.

Scientists tested an extract of saffron on men who were experiencing sexual dysfunction as a result of their prescription antidepressant. 76

In a double-blind trial, researchers enlisted 36 married men whose symptoms of major depressive disorder had been successfully stabilized on Prozac® (fluoxetine)—but who had complaints of sexual impairment. They were randomly assigned to add to their usual dosages of Prozac®, 2 daily doses of either 15 milligrams of saffron or a placebo. Sexual function was assessed using a standard index.76

After just 4 weeks, the men in the Prozac®-plus-saffron group had experienced significantly greater improvement in erectile function and intercourse satisfaction than in the Prozac®-plus-placebo group. The team determined that saffron is a “tolerable and efficacious treatment” for male sexual dysfunction induced by Prozac®.76

Next, scientists set out to determine if saffron could similarly offset the unwanted sexual effects experienced by women taking a prescription antidepressant. 78

A team enlisted 38 women, all of whom had major depression that had been stabilized on Prozac®—but who suffered from various types of sexual dysfunction induced by this antidepressant. In the double-blind study, half of the women were randomly assigned a supplement of 30 milligrams daily of saffron extract while the rest took a placebo. All participants continued to take their usual dosage of Prozac®, and assessments were made using the Female Sexual Function Index (FSFI).78

After 4 weeks—despite still taking the same antidepressant that had induced the unwanted sexual symptoms in the first place—women in the saffron group experienced significant improvement in total sexual function, arousal, lubrication, and pain.78


Male and female sexual dysfunction is often an indicator of underlying disease factors—including cardiovascular, neurological, metabolic, and other disease pathways. Drug options for men generally provide only short-term relief from sexual dysfunction symptoms—but do not address the underlying physiological cause that can lead to serious disease. And women simply have no available drug options (other than hormone replacement).

Fortunately, scientists have identified several natural compounds—for both men and women—that reverse the root causes of sexual dysfunction. Proper use of these nutrients can help prevent age-related disorders for which sexual dysfunction is often an early warning sign.

In double-blind, placebo-controlled studies, Pycnogenol®,L-arginine aspartate, and icariin have been shown to safely and naturally treat male sexual dysfunction.

Similarly, Cordyceps sinensis, maca (Lepidium meyenii), and EstroG-100TM (a three-extract blend) have been scientifically validated in placebo-controlled trials to safely treat female sexual dysfunction and to alleviate the menopausal symptoms that can trigger it.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.