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New Findings on Coffee’s Cardiovascular Benefits

August 2013

By Julia Pace

Although research into other cancers and their association with coffee drinking is less detailed, the available evidence is still encouraging. Take a look:

  • Studies reveal a decrease in the risk of endometrial cancer of up to 39% in women drinking at least 1 to 2 cups/day, and 62% in women drinking 3 or more cups/day.35, 36
  • The risk of localized esophageal cancer was reduced by 60% among coffee drinkers in one study.37
  • People with either hepatitis B or C infections or both (a high-risk population), who drink at least 3 cups of coffee daily reduce their risk of developing liver cancer by up to 39%.38
  • Even those without such viral infections have a 44% lower risk of developing hepataocellular carcinoma, the most common liver cancer, when they drink 3 or more cups/day.39
  • And the risk of localized prostate cancer has now been shown to decrease by 3% per cup of coffee per day, with higher risk reductions among overweight or obese men.40
Endothelial Function and Your Health
Endothelial Function and Your Health

Studies now show that poor endothelial function is a more accurate predictor of heart attack and stroke risk than most conventional risk markers (like lipid profiles and blood pressure).15,58-63

Your arteries are not simple rigid pipes, or even flexible hoses. They are living, dynamic structures that exert active control over the amount of blood that flows through them.

Arteries detect and respond to variations in blood flow and pressure through a complex signaling system that involves the ultra-thin layer of cells that line their inner surfaces: the endothelium. In health, the endothelium relays signals to the smooth muscle cells that form the actual walls of the arteries. When the endothelium signals “not enough blood flow,” the arterial wall relaxes, the artery dilates, and more blood flows.

But in cardiovascular disease, the endothelial function is impaired.4 People with endothelial dysfunction can’t relax their blood vessels appropriately, so they can’t deliver adequate blood flow to oxygen- and energy-starved tissues.

The result can be devastating. Early on, insufficient blood flow produces ischemia, or insufficient oxygenation of tissues. But in a blindingly short period of time, ischemic tissue dies, producing an infarction.

An infarction in the heart is a heart attack. An infarction in the brain is a stroke.

Optimizing your endothelial function is one of the best ways to lower your risk of succumbing to a stroke or heart attack. Studies now conclusively demonstrate that coffee, both decaf and regular, have powerful beneficial effects on endothelial function.2,18,64-68

Neurodegenerative Diseases Yield to Coffee

Neurodegenerative diseases in the US are rising at an alarming rate. A study published in April 2013 in the New England Journal of Medicine found that nearly 15% of Americans older than 70 suffer from dementia.41 The total monetary costs of dementia in the US as a whole is around $215 billion per year.

There’s now very strong epidemiological evidence that people who drink more coffee are protected against developing Parkinson’s and Alzheimer’s diseases, the most common forms of dementia.42-44 Studies show that coffee consumption lowers the risk for Parkinson’s by up to 74% and cuts the risk of Alzheimer’s and general cognitive decline by up to 51%.45-49

Animal studies reveal some of the basic mechanisms behind this powerful protection. One of the most important ways coffee produces this effect is by preventing type II diabetes. Since diabetes is a known risk factor for developing Alzheimer’s, preventing diabetes ultimately helps prevent Alzheimer’s. One study showed that decaffeinated green coffee improved insulin sensitivity and improved brain energy metabolism, both important factors in Alzheimer’s disease prevention.50

Caffeine appears to be one of the most important components of coffee that is responsible for this dramatic risk reduction. For example, when mice that were engineered to be at high risk for Alzheimer’s disease were given caffeine, they were protected from cognitive impairment.51 This protective effect was also seen in older mice that were already showing signs of cognitive impairment from Alzheimer’s, demonstrating an actual reversal of cognitive impairment and improvement in learning and memory.52

Caffeine also reduces both brain and plasma levels of the toxic Abeta protein (sometimes called the “Alzheimer’s protein” because it’s found in such high concentrations in the brains of Alzheimer’s patients).51-53 Remarkably, in both mice and humans, a single dose of caffeine (equivalent to 5 cups of coffee/day) quickly reduced both brain and plasma levels of toxic Abeta protein.43 This finding may represent the first true disease-modifying treatment of Alzheimer’s. (Current drug therapies can only reduce symptoms; they don’t produce changes in the disease process itself.)

But other components of coffee in addition to caffeine are essential and have been shown to work synergistically with caffeine to protect brain health and function, which means you can’t simply take caffeine pills (a bad idea for many reasons). One study demonstrated this dramatically: only caffeinated coffee—and neither caffeine alone nor decaffeinated coffee—protected against Alzheimer’s.54 Similarly, crude caffeine (a byproduct of coffee decaffeination that still retains non-caffeine components) but not caffeine itself, reduced Abeta levels and microscopic damage to brain memory centers. 55

Chlorogenic acid, a major non-caffeine coffee constituent, protected animals against chemically induced memory impairment—and also reversed cognitive impairments. 56 And eicosanoyl-5-hydroxytryptamide, another coffee component, has anti-inflammatory and antioxidant activities that can protect against Parkinson’s disease in animal models.57

Can Drinking Coffee Help You Live Longer?
Can Drinking Coffee Help You Live Longer?

People who live well into their 90s are evidently doing something right, even if they are also blessed with good genes. Several studies have examined the dietary practices of centenarians and those who live to be 90-100 years seeking for clues to their surprising longevity.

Coffee drinking stands out among the dietary practices that correlate with great age.

A study comparing centenarians with sexa- and octogenarians found that centenarians consumed coffee significantly more frequently than the two younger groups.69 A second study among very elderly people in Rome found that consuming strong espresso coffee more than once a week reduced the risk of dying within 5 years by 79%; and more than 2 cups/week reduced that risk by 65%.70

In light of other studies showing that people of all ages who drink more coffee are less likely to die prematurely compared with those who drink less (or none),8,13 it’s hard to put down that coffee cup knowing it could earn you an extra five years of healthy, vigorous life even well into old age!


Coffee has undergone a dramatic scientific rehabilitation in the past decade, going from feared pariah to welcome ally in the quest for better health and longer life.

New studies provide dramatic insight into coffee’s health-giving benefits, with a special focus on its role in improving endothelial function, the mechanisms by which blood vessels retain their control over blood flow and pressure. By improving endothelial function, coffee can reduce your risk for stroke and heart attack.

Other benefits include a reduced risk for developing diabetes, cancer, and neurodegenerative diseases.

Protect yourself from the ravages of aging. Enjoy that next cup of coffee secure in the knowledge that you are not only producing no harm, but in fact are helping your body fend off some of the most dreaded consequences of aging.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.

How to Boost Coffee’s Benefits
How to Boost Coffee’s Benefits

There’s now compelling evidence that a combination of coffee consumption and green tea offers superior protection than either alone. A 2013 Japanese study found that people who drink 1 or more cups of coffee per day and who drink 2 or more cups of green tea daily have about a 23% lower risk of all strokes, 20% lower risk of ischemic strokes, and about 29% lower risk of hemorrhagic strokes, compared with those who drink neither beverage.3

Fortunately, there are excellent extracts available that contain the green tea polyphenols that confer protection.71,72


Caution: Caffeine consumption can transiently increase blood pressure and heart rate, though most individuals who regularly consume caffeine develop tolerance to these effects. Nevertheless, in very sensitive individuals, caffeine consumption can increase blood pressure significantly (e.g.10 mmHg or more). Caffeine appears to have a more pronounced blood pressure effect on overweight people older than age 70 years.87 To see if caffeine may be raising your blood pressure, check your blood pressure within 30 to 60 minutes of drinking a cup of caffeinated coffee or another caffeinated beverage. If your blood pressure increases by 10 mmHg or more, you may be sensitive to the blood pressure raising effects of caffeine and may want to cut down on caffeine consumption and substitute decaffeinated coffee.


New Polyphenol-Retaining Coffees Boost Health Benefits
New Polyphenol-Retaining Coffees Boost Health Benefits

In their green, unroasted state, coffee beans are an incredibly rich source of health-promoting polyphenols, particularly chlorogenic acid. However, before these beans are consumed as brewed coffee, they are subjected to varying degrees of roasting—often at very elevated temperatures ranging from 375 to 440 degrees Fahrenheit. These extreme temperatures destroy an enormous amount of the beneficial polyphenols, leaving the standard coffee found on supermarket shelves substantially less healthful than it could be.

In order to preserve the green coffee bean’s original polyphenol content, a new, patented technique has been developed. Under controlled temperature conditions, the green coffee beans are first soaked in water and then drained before roasting.

Because many polyphenols, including chlorogenic acid, are water-soluble compounds, soaking the beans before roasting provides an opportunity to “capture” the polyphenols at a controlled temperature before the beans are exposed to polyphenol-destroying high-temperature roasting.73,74 After roasting, the beans are “quenched,” meaning that they are placed back in the polyphenol-rich water retained from the pre-soaking phase before roasting. The result is that the beans reabsorb the polyphenols from the water, and much of their original polyphenol content is “rescued.”74

This process results in a roasted coffee bean displaying all the desired flavor and richness of traditional roasted coffee, but with a substantial increase in its content of polyphenols, especially chlorogenic acid. In fact, the final brewed beverage has been found to contain as much as a 120% increase in polyphenols overall, and up to an astonishing 250% increase in chlorogenic acid content versus standard roasting procedures. 74

Studies show that, for maximum health benefit, you would need to drink anywhere from 4 to 12 cups of conventional coffee daily.75-86 That’s a lot of coffee to drink and for many people, consuming that much may result in unpleasant side effects. The advantage of these newer “polyphenol-retaining” coffees, with twice the chlorogenic acid content, is their potential to deliver similar benefits in only half the number of cups.