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Turn Off the Cytokine Switch

January 2014

By Morris Eagleton


Chronic inflammation accelerates aging, producing symptoms that we recognize as diseases that cause early death. Scientists have now discovered the accelerator switch, in the form of HMGB1, the molecule that triggers the release of inflammatory cytokines under a wide variety of circumstances.

Anti-HMGB1 therapies, therefore, are avidly sought-after by big pharma companies. While producing dramatic results in the laboratory, however, no anti-HMGB1 drug is anywhere near market-ready because treatments to date use large antibody molecules that can’t be given orally and that have unacceptable side effects.

But mung beans and green tea, in use for thousands of years in traditional Chinese medicine, contain safe, powerful HMGB1-fighting substances. Extract of mung bean seed coat and EGCG from green tea leaf extract can be given orally, and in preclinical studies have proven to be highly effective at shutting down HMGB1-induced inflammation in a life-saving fashion.

If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.


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