Findings from University of Sao Paulo Update Understanding of Peptides and Proteins (Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-b Peptide in Mice)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Peptides and Proteins. According to news originating from Piracicaba, Brazil, by NewsRx correspondents, research stated, "Alzheimer's disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the disease but are expensive and commonly cause side effects that are uncomfortable for treated patients."
Financial support for this research came from Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (see also Peptides and Proteins).
Our news journalists obtained a quote from the research from the University of Sao Paulo, "Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent a promising field of study currently gaining attention. To this end, here we demonstrate the effects of pomegranate (Punica granatum) peel extract (PPE) regarding spatial memory, biomarkers of neuroplasticity, oxidative stress and inflammation in a mouse model of neurodegeneration. Male C57Bl/6 mice were chronically infused for 35 days with amyloid-b peptide 1-42 (Ab) or vehicle (control) using mini-osmotic pumps. Another group, also infused with Ab, was treated with PPE (p.o.-bA+PPE, 800 mg/kg/day). Spatial memory was evaluated in the Barnes maze. Animals treated with PPE and in the control group exhibited a reduction in failure to find the escape box, a finding that was not observed in the Ab group. The consumption of PPE reduced amyloid plaque density, increased the expression of neurotrophin BDNF and reduced the activity of acetylcholinesterase enzyme. A reduction in lipid peroxidation and in the concentration of the pro-inflammatory cytokine TNF-a was also observed in the PPE group. No hepatic lesions were observed in animals treated with PPE."
According to the news editors, the research concluded: "Administration of pomegranate peel extract has neuroprotective effects involving multiple mechanisms to prevent establishment and progression of the neurodegenerative process induced by infusion with amyloid-b peptide in mice."
For more information on this research see: Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-b Peptide in Mice. Plos One, 2016;11(11):e0166123. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
The news correspondents report that additional information may be obtained from M.C. Morzelle, Dept. of Agri-food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of Sao Paulo, Padua Dias Avenue, PO Box 9, 13418-900, Piracicaba, SP, Brazil. Additional authors for this research include J.M. Salgado, M. Telles, D. Mourelle, P. Bachiega, H.S. Buck and T.A Viel.
Keywords for this news article include: Brazil, Amyloid, Piracicaba, South America, Peptides and Proteins.
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