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Studies Conducted at National Research Center on Liver Cancer Recently Reported (Biochemical and molecular evidences for the antitumor potential of...

Cancer Weekly

04-20-17

Studies Conducted at National Research Center on Liver Cancer Recently Reported (Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology - Liver Cancer. According to news reporting originating from Giza, Egypt, by NewsRx correspondents, research stated, "Hepatocellular carcinoma (HCC) is one of the deadliest primary cancers, with a 5-year survival rate of 10% or less. This study was undertaken to elucidate the underlying biochemical and molecular mechanisms in favor of N-nitrosodiethylamine-induced hepatocellular carcinoma."

Our news editors obtained a quote from the research from National Research Center, "Furthermore, the aim of this work was extended to explore the efficacy of Ginkgo biloba leaves extract in deterioration of HCC in rats. In the current study, HCC group experienced significant downregulation of ING-3 gene expression and upregulation of Foxp-1 gene expression in liver. Treatment of HCC groups with Ginkgo biloba leaves extract resulted in upregulation of ING-3 and downregulation of Foxp-1 gene expression in liver. In addition, there was significant increase in serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and glypican-3 (GPC-3) levels in HCC group versus the negative control group. In contrast, the groups with HCC subjected to either high or low dose of Ginkgo biloba leaves extract elicited significant reduction (p <0.05) of AFP, CEA and GPC-3 in serum compared to the untreated HCC rats. Besides, histological examination of liver tissue sections of rats in HCC group revealed typical anaplasia. Interestingly, treatment with Ginkgo biloba leaves extract elicited marked improvement in the histological feature of liver tissue in HCC groups."

According to the news editors, the research concluded: "This research indicated that the carcinogenic potency of N-nitrosodiethylamine targeted multiple systems on the cellular and molecular levels. In addition, the results of the current study shed light on the promising anticancer activity of Ginkgo biloba leaves extract in treatment of hepatocellular carcinoma induced chemically in the experimental model through its apoptotic and antiproliferative properties."

For more information on this research see: Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents. Acta Biochimica Polonica, 2016;64(1):25-33 (see also Oncology - Liver Cancer).

The news editors report that additional information may be obtained by contacting H.H. Ahmed, Hormones Department, National Research Centre, Dokki, Giza, Egypt. Additional authors for this research include W.G. Shousha, H.A. El-Mezayen, S.A. El-Toumy, A.H. Sayed and A.R Ramadan.

Keywords for this news article include: Giza, Egypt, Africa, Genetics, Oncology, Carcinomas, Biochemicals, Biochemistry, Liver Cancer.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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