Studies from Affiliated Hospital 1 Describe New Findings in Brain Death (Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings)
By a News Reporter-Staff News Editor at Science Letter -- A new study on Central Nervous System Diseases and Conditions - Brain Death is now available. According to news reporting originating in Guangdong, People's Republic of China, by NewsRx journalists, research stated, "This study aimed to investigate the protective effects of EGb761, a Ginkgo Biloba extract, against brain death-induced kidney injury. Sixty male Sprague Dawley rats were randomly divided into six groups: sham, brain-death ( BD), BD + EGb b48h (48 hours before BD), BD + EGb 2 h (2 hours after BD), BD + EGb 1 h, and BD + EGb 0.5 h. Six hours after BD, serum sample and kidney tissues were collected for analyses."
The news reporters obtained a quote from the research from Affiliated Hospital 1, "The levels of blood urea nitrogen (BUN) and serum creatinine significantly elevated in the BD group than in sham group. In all the EGb761-treated BD animals except for the BD + Gb 2 h group, the levels of BUN and serum creatinine significantly reduced (all P< 0.01). EGb761 attenuated tubular injury and lowered the histological score. In addition, the longer duration of drug treatment was, the better protective efficacy could be observed. EGb761 significantly reduced IL-1 beta, IL-6, TNF-alpha, MCP-1, IP-10 mRNA expression and macrophage infiltration in the kidney. EGb761 treatment at 48 hour before brain death significantly attenuate the levels of p-JNK-MAPK, p-p38-MAPK, and p-STAT3 proteins (all P< 0.05, compared to BD group). In summary, our data showed that EGb761 treatment protected donor kidney from BD-induced damages by blocking SAPK and JAK-STAT signalings."
According to the news reporters, the research concluded: "Early administration of EGb761 can provide better protective efficacy."
For more information on this research see: Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings. Scientific Reports, 2017;7():1-10. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)
Our news correspondents report that additional information may be obtained by contacting L.S. Liu, Sun Yat Sen UniversityOrgan Transplant Center, Affiliated Hosp 1, Guangzhou 510080, Guangdong, People's Republic of China. Additional authors for this research include Y.Y. Xiong, H.X. Zhang, J. Li, D. Wang, W.F. Chen, X.P. Yuan, Q. Su, W.W. Li, H.T. Huang, Z.R. Bi, L.S. Liu and C.X. Wang (see also Central Nervous System Diseases and Conditions - Brain Death).
Keywords for this news article include: Guangdong, People's Republic of China, Asia, Central Nervous System Diseases and Conditions, Neurobehavioral Manifestations, Brain Diseases and Conditions, Neurologic Manifestations, Consciousness Disorders, Unconsciousness, Brain Death, Nephrology, Cytokines, Kidney, Coma, Affiliated Hospital 1.
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