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Data on Choroidal Neovascularization Reported by Researchers at Children's Hospital (Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated...

Angiogenesis Weekly

10-13-17

Data on Choroidal Neovascularization Reported by Researchers at Children's Hospital (Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice)

By a News Reporter-Staff News Editor at Angiogenesis Weekly -- New research on Eye Diseases and Conditions - Choroidal Neovascularization is the subject of a report. According to news reporting originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "Neovascular age-related macular degeneration (AMD) is a major cause of legal blindness in the elderly. Diets with omega3-long-chain-polyunsaturated-fatty-acid (omega 3-LCPUFA) correlate with a decreased risk of AMD."

Our news editors obtained a quote from the research from Children's Hospital, "Dietary omega 3-LCPUFA versus omega 6-LCPUFA inhibits mouse ocular neovascularization, but the underlying mechanism needs further exploration. The aim of this study was to investigate if adiponectin (APN) mediated x omega 3-LCPUFA suppression of neovessels in AMD. The mouse laser-induced choroidal neovascularization (CNV) model was used to mimic some of the inflammatory aspect of AMD. CNV was compared between wild-type (WT) and Apn(-/-) mice fed either otherwise matched diets with 2% x3 or 2% omega 6-LCPUFAs. Vldlr(-/-) mice were used to mimic some of the metabolic aspects of AMD. Choroid assay ex vivo and human retinal microvascular endothelial cell (HRMEC) proliferation assay in vitro was used to investigate the APN pathway in angiogenesis. Western blot for p-AMPK alpha/AMPK alpha and qPCR for Apn, Mmps, and IL-10 were used to define mechanism. omega 3-LCPUFA intake suppressed laser-induced CNV in WT mice; suppression was abolished with APN deficiency. omega 3-LCPUFA, mediated by APN, decreased mouse Mmps expression. APN deficiency decreased AMPK alpha phosphorylation in vivo and exacerbated choroid-sprouting ex vivo. APN pathway activation inhibited HRMEC proliferation and decreased Mmps. In Vldlr(-/-) mice, omega 3-LCPUFA increased retinal AdipoR1 and inhibited NV. omega 3-LCPUFA decreased IL-10 but did not affect Mmps in Vldlr(-/-) retinas. APN in part mediated omega 3-LCPUFA inhibition of neovascularization in two mouse models of AMD."

According to the news editors, the research concluded: "Modulating the APN pathway in conjunction with a omega 3-LCPUFA-enriched-diet may augment the beneficial effects of omega 3-LCPUFA in AMD patients."

For more information on this research see: Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Investigative Ophthalmology & Visual Science, 2017;58(10):3862-3870. Investigative Ophthalmology & Visual Science can be contacted at: Assoc Research Vision Ophthalmology Inc, 12300 Twinbrook Parkway, Rockville, MD 20852-1606, USA. (The Association for Research in Vision and Ophthalmology - www.arvo.org; Investigative Ophthalmology & Visual Science - www.iovs.org/)

The news editors report that additional information may be obtained by contacting L.E.H. Smith, Harvard Med Sch, Boston Childrens Hosp, Dept. of Ophthalmol, Boston, MA, United States. Additional authors for this research include R. Lieg, Z.X. Wang, Y. Gong, C.H. Liu, Y. Sun, B. Cakir, S.B. Burnim, S.S. Meng, C. Lofqvist, J.P. SanGiovanni, A. Hellstrom and Z.J. Fu (see also Eye Diseases and Conditions - Choroidal Neovascularization).

Keywords for this news article include: Boston, Massachusetts, United States, North and Central America, Intercellular Signaling Peptides and Proteins, Age-Related Macular Degeneration, Choroid Diseases and Conditions, Uveal Diseases and Conditions, Choroidal Neovascularization, Eye Diseases and Conditions, Adiponectin, Adipokines, Children's Hospital.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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