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New Findings Reported from Shiraz University of Medical Sciences Describe Advances in Liver Fibrosis (Carnosine ameliorates liver fibrosis and...

Gastroenterology Week

10-13-17

New Findings Reported from Shiraz University of Medical Sciences Describe Advances in Liver Fibrosis (Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats)

By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Liver Diseases and Conditions - Liver Fibrosis have been published. According to news reporting out of Shiraz, Iran, by NewsRx editors, research stated, "Chronic liver injury and cirrhosis leads to liver failure. Hyperammonemia is a deleterious consequence of liver failure."

Financial support for this research came from Shiraz University of Medical Sciences (see also Liver Diseases and Conditions - Liver Fibrosis).

Our news journalists obtained a quote from the research from the Shiraz University of Medical Sciences, "On the other hand, oxidative stress seems to play a pivotal role in the pathogenesis of liver fibrosis as well as in the cytotoxic mechanism of ammonia. There is no promising therapeutic agent against ammonia-induced complications. The present study was conducted to evaluate the role of carnosine (CA) administration on liver pathological changes, elevated plasma ammonia, and its consequent events in cirrhotic rats. Bile duct ligated (BDL) rats were used as a model of cirrhosis. CA (250, 500, and 1000 mg/kg, daily, i.p) was administered for 28 consecutive days to BDL animals. At the end of treatments, markers of oxidative stress and liver fibrosis was determined in liver and serum biomarkers of liver injury and plasma ammonia was assessed. Moreover, changes in animals' locomotor activity were monitored. Severe bridging fibrosis, inflammation, and necrosis in liver, along with elevated serum biomarkers of liver injury were evident in BDL animals. Furthermore, plasma ammonia was drastically elevated in cirrhotic rats and animals' locomotor activity was suppressed. It was found that CA (250, 500, and 1000 mg/kg, daily, i.p) significantly alleviated liver injury and its consequent events in cirrhotic rats."

According to the news editors, the research concluded: "The data suggested that CA is not only a useful and safe agent to preserve liver function, but also prevented hyperammonemia and brain damage as a deleterious consequence of cirrhosis and liver failure."

For more information on this research see: Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats. Clinics and Research in Hepatology and Gastroenterology, 2017;41(4):424-434. Clinics and Research in Hepatology and Gastroenterology can be contacted at: Elsevier Masson, Via Paleocapa 7, 20121 Milano, Italy. (Elsevier - www.elsevier.com; Clinics and Research in Hepatology and Gastroenterology - www.journals.elsevier.com/clinics-and-research-in-hepatology-and-gastroenterology/)

Our news journalists report that additional information may be obtained by contacting R. Heidari, Shiraz University of Medical Science, Pharmaceut Sci Res Center, Shiraz, Fars, Iran. Additional authors for this research include A. Jamshidzadeh, Z. Latifpour, M.M. Ommati, N. Abdoli, S. Mousavi, N. Azarpira, A. Zarei, M. Zarei, B. Asadi, M. Abasvali, Y. Yeganeh, F. Jafari, A. Saeedi, A. Najibi and E. Mardani.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.clinre.2016.12.010. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Shiraz, Iran, Asia, Fibrosis, Diagnostics and Screening, Liver Diseases and Conditions, Hepatic Insufficiency, Nitrogen Compounds, Gastroenterology, Liver Cirrhosis, Hyperammonemia, Liver Fibrosis, Neuropeptides, Liver Failure, Dipeptides, Hepatology, Carnosine, Proteins, Peptides, Ammonia, Shiraz University of Medical Sciences.

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