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New Findings from Central South University in the Area of Liver Fibrosis Described (Effects of aspirin and enoxaparin in a rat model of liver...

Gastroenterology Week

10-13-17

New Findings from Central South University in the Area of Liver Fibrosis Described (Effects of aspirin and enoxaparin in a rat model of liver fibrosis)

By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Liver Diseases and Conditions - Liver Fibrosis have been published. According to news reporting from Changsha, People's Republic of China, by NewsRx journalists, research stated, "To examine the effects of aspirin and enoxaparin on liver function, coagulation index and histopathology in a rat model of liver fibrosis. Forty-five male Sprague-Dawley rats were randomly divided into the control group (n = 5) and model group (n = 40)."

The news correspondents obtained a quote from the research from Central South University, "Thioacetamide (TAA) was used to induce liver fibrosis in the model group. TAA-induced fibrotic rats received TAA continuously (n = 9), TAA + low-dose aspirin (n = 9), TAA + high-dose aspirin (n = 9) or TAA + enoxaparin (n = 9) for 4 wk. All rats were euthanized after 4 wk, and both hematoxylin-eosin and Masson staining were performed to observe pathological changes in liver tissue. Liver fibrosis was assessed according to the METAVIR score. Compared with untreated cirrhotic controls, a significant improvement in fibrosis grade was observed in the low-dose aspirin, high-dose aspirin and enoxaparin treated groups, especially in the high-dose aspirin treated group. Alanine aminotransferase and total bilirubin were higher, albumin was lower and both prothrombin time and international normalized ratio were prolonged in the four treatment groups compared to controls. No significant differences among the four groups were observed."

According to the news reporters, the research concluded: "Aspirin and enoxaparin can alleviate liver fibrosis in this rat model."

For more information on this research see: Effects of aspirin and enoxaparin in a rat model of liver fibrosis. World Journal of Gastroenterology, 2017;23(35):6412-6419. World Journal of Gastroenterology can be contacted at: Baishideng Publishing Group Inc, 8226 Regency Dr, Pleasanton, CA 94588, USA. (Baishideng Publishing Group - www.wjgnet.com/; World Journal of Gastroenterology - www.wjgnet.com/1007-9327/current.htm)

Our news journalists report that additional information may be obtained by contacting C.J. Li, Central South University, Xiangya Hosp 2, Dept. of Gastroenterol, Changsha 410011, Hunan, People's Republic of China. Additional authors for this research include Z.H. Yang, X.L. Shi and D.L. Liu (see also Liver Diseases and Conditions - Liver Fibrosis).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.3748/wjg.v23.i35.6412. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Changsha, People's Republic of China, Asia, Liver Diseases and Conditions, Organic Chemicals, Carboxylic Acids, Gastroenterology, Salicylic Acids, Liver Cirrhosis, Liver Fibrosis, Benzoic Acids, Hydroxy Acids, Aspirin, Central South University.

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