Researchers from Guangdong Medical University Describe Findings in Osteoporosis (Preventive effects of Polygonum multiflorum on glucocorticoid-induced osteoporosis in rats)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Musculoskeletal Diseases and Conditions - Osteoporosis have been presented. According to news reporting originating in Guangdong, People's Republic of China, by NewsRx journalists, research stated, "In Traditional Chinese Medicine, (PM) is known for its anti-aging properties. A previous study by our group showed that extracts of PM were able to prevent and treat bone loss , and the active components emodin and 2,3,5,4,-tetrahydroxystilbene-2--b-glucoside (TSG) promoted the osteogenic differentiation of mesenchymal stem cells."
The news reporters obtained a quote from the research from Guangdong Medical University, "The aim of the present study was to investigate the preventive effects of PM on glucocorticoid-induced osteoporosis (GIO) in rats. A crude extract of PM was prepared with 75% ethanol, purified and enriched using a D-101 macroresin column and elution with 30% ethanol, and the material obtained was assessed by high-performance liquid chromatography. Male or female Sprague Dawley rats (n=180) were randomly divided into nine groups: Control, prednisone, prednisone plus calcitriol (CAL), prednisone plus 30% ethanolic eluate of PM [high (H), medium (M) and low (L) dose] and prednisone plus crude extract of PM (H, M and L dose). Prednisone was orally administered to the osteoporosis model rats for 21 weeks, alongside which they received PM extracts. The weight of the viscera, anterior tibial muscle and other tissues was recorded at the end of the experiment. The femur and lumbar vertebra were collected for the measurement of three-dimensional microarchitecture by micro-computed tomography scanning, assessment of biomechanical properties and determination of bone mineral density (BMD). In the 30% ethanolic eluate of the PM extract, the content of TSG and combined anthraquinone was 9.20 and 0.15%, respectively, and that in the crude extract of PM was 2.23 and 0.03%, respectively. Over 6 weeks, the weight of the rats the in prednisone group decreased (p <0.05), while the weight of rats treated with M and H doses of 30% ethanolic eluate was increased compared with that in the prednisone group (p <0.05). Rats exposed to prednisone exhibited a deteriorated bone microarchitecture, low BMD, decreased bone volume/total volume and poor biomechanical properties. Furthermore, the weight of the adrenal gland and the anterior tibial muscle was decreased. 30% ethanolic eluate of PM at M and L doses and crude extract of PM at the H dose counteracted the alterations of skeletal and other characteristics induced by prednisone in rats, as did CAL."
According to the news reporters, the research concluded: "Extracts of PM exerted a protective effect on bone tissue in GIO rats."
For more information on this research see: Preventive effects of Polygonum multiflorum on glucocorticoid-induced osteoporosis in rats. Experimental and Therapeutic Medicine, 2017;14(3):2445-2460 (see also Musculoskeletal Diseases and Conditions - Osteoporosis).
Our news correspondents report that additional information may be obtained by contacting M. Zhou, Dept. of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong 524023, People's Republic of China. Additional authors for this research include J. Li, J. Wu, Y. Yang, X. Zeng, X. Lv, L. Cui, W. Yao and Y. Liu.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.3892/etm.2017.4802. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Asia, Guangdong, Osteoporosis, Bone Research, Glucocorticoids, Adrenal Cortex Hormones, People's Republic of China, Metabolic Bone Diseases and Conditions, Musculoskeletal Diseases and Conditions.
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