New Findings in Osteoporosis Described from Department of Obstetrics (Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions)
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Musculoskeletal Diseases and Conditions - Osteoporosis have been presented. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "With rapidly ageing populations worldwide, the incidence of osteoporosis has reached epidemic proportions. Reactive oxygen species (ROS), a by-product of oxidative stress and ageing, has been thought to induce osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells (MSCs)."
Financial support for this research came from Ministry of Science and Technology (see also Musculoskeletal Diseases and Conditions - Osteoporosis).
Our news journalists obtained a quote from the research from the Department of Obstetrics, "However, specific mechanisms of how ROS results in alterations on MSC differentiation capacity have been inconsistently reported. We found that H O , an ROS, simultaneously induced MSC lineage commitment towards adipogenesis and away from osteogenesis at the functional as well as transcriptional level. In addition, H O decreased the activities of SIRT1, a histone deacetylase and longevity gene. By silencing and reconstituting SIRT1 in MSCs, we demonstrated that H O exerted its disparate effects on adipogenic/osteoblastic lineage commitment mainly through modulating SIRT1 expression levels. Treatment with resveratrol, a SIRT1 agonist, can also reverse this ROS-induced adipogenesis/osteogenesis lineage imbalance. Moreover, SIRT1 regulation of RUNX2 transcriptional activity was mediated through deacetylation of the ROS-sensitive transcription factor FOXO3a. Taken together, our data implicate SIRT1 as playing a vital role in ROS-directed lineage commitment of MSCs by modulating two lineages simultaneously."
According to the news editors, the research concluded: "Our findings on the critical role of SIRT1 in ROS/age-related perturbations of MSC differentiation capacity highlight this molecule as a target for maintenance of MSC stemness as well as a potential anabolic target in osteoporosis."
For more information on this research see: Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions. Journal of Cellular and Molecular Medicine, 2017;():. Journal of Cellular and Molecular Medicine can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Cellular and Molecular Medicine - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1582-4934)
The news correspondents report that additional information may be obtained from C.H. Lin, Dept. of Obstetrics, Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, Taipei, Taiwan. Additional authors for this research include N.T. Li, H.S. Cheng and M.L Yen.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/jcmm.13356. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
The publisher's contact information for the Journal of Cellular and Molecular Medicine is: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA.
Keywords for this news article include: Asia, Taipei, Taiwan, Genetics, Osteoblasts, Epidemiology, Osteoporosis, Stem Cell Research, Mesenchymal Stem Cells, Connective Tissue Cells, Metabolic Bone Diseases and Conditions, Musculoskeletal Diseases and Conditions.
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