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New Liver Cancer Findings from Huazhong University of Science and Technology Outlined (n-3 fatty acid-based parenteral nutrition improves...

Clinical Trials Week

10-13-17

New Liver Cancer Findings from Huazhong University of Science and Technology Outlined (n-3 fatty acid-based parenteral nutrition improves postoperative recovery for cirrhotic patients with liver cancer: A randomized controlled clinical trial)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Oncology - Liver Cancer have been published. According to news originating from Hubei, People's Republic of China, by NewsRx correspondents, research stated, "A new lipid emulsion enriched in n-3 fatty acid has been reported to prevent hepatic inflammation in patients following major surgery. However, the role of n-3 fatty acid-based parenteral nutrition for postoperative patients with cirrhosis-related liver cancer is unclear."

Our news journalists obtained a quote from the research from the Huazhong University of Science and Technology, "We investigated the safety and efficacy of n-3 fatty acid-based parenteral nutrition for cirrhotic patients with liver cancer followed hepatectomy. A prospective randomized controlled clinical trial (Registered under ClinicalTrials.gov Identifier no. NCT02321202) was conducted for cirrhotic patients with liver cancer that underwent hepatectomy between March 2010 and September 2013 in our institution. We compared isonitrogenous total parenteral nutrition with 20% Structolipid and 10% n-3 fatty acid (Omegaven, Fresenius-Kabi, Germany) (treatment group) to Structolipid alone (control group) for five days postoperatively, in the absence of enteral nutrition. We enrolled 320 patients, and 312 (97.5%) were included in analysis (155 in the control group and 157 in the treatment group). There was a significant reduction of morbidity and mortality in the treatment group, when compared with the control group (total complications 78 [50.32%] vs. 46 [29.30%]; P< 0.001, total infective complications, 30 [19.35%] vs. 15 [9.55%]; P = 0.014), overall mortality (5 [3.23%j vs. 1 [0.64%]; P = 0.210), and hospital stay (12.56 +/- 3.21 d vs. 10.17 +/- 3.15 d; P = 0.018)."

According to the news editors, the research concluded: "We found that addition of n-3 fatty acid-based parenteral nutrition significantly improved postoperative recovery for cirrhotic patients with liver cancer following hepatectomy, with a significant reduction in overall mortality and length of hospital stay."

For more information on this research see: n-3 fatty acid-based parenteral nutrition improves postoperative recovery for cirrhotic patients with liver cancer: A randomized controlled clinical trial. Clinical Nutrition, 2017;36(5):1239-1244. Clinical Nutrition can be contacted at: Churchill Livingstone, Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh EH1 3AF, Midlothian, Scotland. (Elsevier - www.elsevier.com; Clinical Nutrition - www.journals.elsevier.com/clinical-nutrition/)

The news correspondents report that additional information may be obtained from B.X. Zhang, Huazhong University of Science & Technology, Inst Hepatopancreatobililary Surg, Tongji Hosp, Tongji Med College, Wuhan 430030, Hubei, People's Republic of China. Additional authors for this research include G. Wei, R. Li, Y.J. Wang, J. Yu, R. Wang, H. Xiao, C. Wu, C. Leng, B.H. Zhang and X.P. Chen (see also Oncology - Liver Cancer).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.clnu.2016.08.002. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Hubei, People's Republic of China, Asia, Digestive System Surgical Procedures, Clinical Trials and Studies, Parenteral Nutrition, Nutritional Support, Diet and Nutrition, Clinical Research, Feeding Methods, Liver Cancer, Hepatectomy, Hospital, Oncology, Surgery, Huazhong University of Science and Technology.

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