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Reports from China Pharmaceutical University Advance Knowledge in Hormones (Melatonin ameliorates Ab1-42 -induced Alzheimer's cognitive deficits in...

Drug Week

10-20-17

Reports from China Pharmaceutical University Advance Knowledge in Hormones (Melatonin ameliorates Ab1-42 -induced Alzheimer's cognitive deficits in mouse model)

By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Drugs and Therapies - Hormones have been presented. According to news reporting originating in Nanjing, People's Republic of China, by NewsRx journalists, research stated, "The objective of this study was to evaluate whether melatonin could ameliorate cognitive function in Ab -induced mouse model and its underlying mechanisms. Series behaviour tests were performed to demonstrate the amelioration of cognitive function of the Alzheimer's disease (AD) mice induced by Ab."

The news reporters obtained a quote from the research from China Pharmaceutical University, "Additionally, enzyme-linked immunosorbent assay was applied to detect the expression of Ab , BACE1 and p-tau protein in the brain of the AD mice. JC-1 was performed to investigate the role in alleviating mitochondrial damage by melatonin in vitro. Western blot was used to detect the expression of melatonin on apoptosis-related factors caspase-3 and Bcl-2, as well as the expressions of GSK-3b and PP2A to further determine the mechanisms of melatonin on the expression of p-tau protein. Melatonin significantly ameliorated the cognitive function and mitochondrial damage in AD mice, reduced the expression levels of GSK-3b, caspase-3, Ab , BACE1, p-tau protein and increased the expressions of PP2A and Bcl-2."

According to the news reporters, the research concluded: "From the overall results, we concluded that melatonin alleviated the mitochondrial damage effectively and decreased the expressions of the p-tau and some key proteins of apoptosis, leading to the improvement of cognitive function of the mice induced by Ab ."

For more information on this research see: Melatonin ameliorates Ab1-42 -induced Alzheimer's cognitive deficits in mouse model. The Journal of Pharmacy and Pharmacology, 2017;(): (see also Drugs and Therapies - Hormones).

Our news correspondents report that additional information may be obtained by contacting Y.H. Gong, Dept. of Pharmacology, China Pharmaceutical University, Nanjing, People's Republic of China. Additional authors for this research include N. Hua, X. Zang, T. Huang and L. He.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/jphp.12830. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Asia, Nanjing, Caspase, Dementia, Hormones, Melatonin, Tauopathies, tau Proteins, Alzheimer Disease, Drugs and Therapies, Cytoskeletal Proteins, Enzymes and Coenzymes, People's Republic of China, Brain Diseases and Conditions, Microtubule Associated Proteins, Neurodegenerative Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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