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Researchers from University of Oxford Detail Findings in Clinical Trials and Studies (A Randomized Trial of Vitamin D Supplementation on Vascular...

Clinical Trials Week

10-20-17

Researchers from University of Oxford Detail Findings in Clinical Trials and Studies (A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Clinical Research - Clinical Trials and Studies. According to news reporting originating in Oxford, United Kingdom, by NewsRx journalists, research stated, "Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D<= 20 ng/ml)."

The news reporters obtained a quote from the research from the University of Oxford, "We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: 5.49%; 95% confidence interval, 4.34% to 6.64%; P<0.001). Intervention also led to significant favorable changes in pulse wave velocity and circulating IL-6 levels."

According to the news reporters, the research concluded: "Thus, in nondiabetic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplementation may improve vascular function."

For more information on this research see: A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD. Journal of the American Society of Nephrology, 2017;28(10):3100-3108. Journal of the American Society of Nephrology can be contacted at: Amer Soc Nephrology, 1725 I St, Nw Ste 510, Washington, DC 20006, USA (see also Clinical Research - Clinical Trials and Studies).

Our news correspondents report that additional information may be obtained by contacting V. Jha, University of Oxford, George Inst Global Hlth, Oxford, United Kingdom. Additional authors for this research include A.K. Yadav, A. Lal, V. Kumar, M. Singhal, L. Billot, K.L. Gupta, D. Banerjee and V. Kumar.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1681/ASN.2017010003. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Oxford, United Kingdom, Europe, Nutritional and Metabolic Diseases and Conditions, Risk and Prevention, Deficiency Diseases and Conditions, Clinical Trials and Studies, Vitamin D Deficiency, Nutrition Disorders, Clinical Research, Malnutrition, Avitaminosis, University of Oxford.

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