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Investigators at University of Naples Federico II Detail Findings in Vitamin D Deficiency (Vitamin D deficiency is a risk factor for infections in...

Clinical Trials Week

10-20-17

Investigators at University of Naples Federico II Detail Findings in Vitamin D Deficiency (Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis)

By a News Reporter-Staff News Editor at Clinical Trials Week -- A new study on Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency is now available. According to news reporting originating from Naples, Italy, by NewsRx correspondents, research stated, "To evaluate the prevalence of vitamin D deficiency and its impact on infections in HCV-related liver cirrhosis. We enrolled 291 patients affected by HCV-related liver cirrhosis."

Our news editors obtained a quote from the research from the University of Naples Federico II, "Serum vitamin D levels were dosed at enrolment. The presence of infection was assessed at baseline and during follow-up based on physical examination and laboratory analyses. Vitamin D deficiency (< 20 ng/mL) was diagnosed in 68.3% of patients, and a total of 102 infections were detected. Urinary tract infections were the most common infections diagnosed (41.2%). Vitamin D deficiency rates were higher in patients with decompensated cirrhosis (Child-Pugh B vs A p = 0.008, and Child-Pugh C vs A p = 0.024). Infection was significantly associated with vitamin D deficiency (p < 0.001), MELD score > 15 (p = 0.003), Child-Pugh class B/C vs A (p < 0.001), and active hepatocellular carcinoma (HCC) (p < 0.001). At multivariate analysis, vitamin D deficiency (p < 0.01), HCC (p < 0.05), hospitalization (p < 0.001) and exposure to immunosuppressant agents (p < 0.05) were independent risk factors for infection at baseline."

According to the news editors, the research concluded: "Vitamin D may play a role in the development of infections in patients affected by liver cirrhosis, and preventive strategies with vitamin D supplementation are to be evaluated in randomized controlled trials."

For more information on this research see: Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis. International Journal of Infectious Diseases, 2017;63():23-29. International Journal of Infectious Diseases can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; International Journal of Infectious Diseases - www.journals.elsevier.com/international-journal-of-infectious-diseases/)

The news editors report that additional information may be obtained by contacting A.R. Buonomo, University of Naples Federico II, Sect Infect Dis, Dept. of Clin Med & Surg, I-80131 Naples, Italy. Additional authors for this research include E. Zappulo, R. Scotto, B. Pinchera, G. Perruolo, P. Formisano, G. Borgia and I. Gentile (see also Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ijid.2017.07.026. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Naples, Italy, Europe, Nutritional and Metabolic Diseases and Conditions, Risk and Prevention, Diagnostics and Screening, Digestive System Diseases and Conditions, Deficiency Diseases and Conditions, Liver Diseases and Conditions, Vitamin D Deficiency, Nutrition Disorders, Gastroenterology, Liver Cirrhosis, Malnutrition, Avitaminosis, Hepatology, University of Naples Federico II.

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