Investigators at National Institute on Alcohol Abuse and Alcoholism Describe Findings in Proteomics (Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice)
By a News Reporter-Staff News Editor at Proteomics Weekly -- A new study on Proteomics is now available. According to news reporting out of Bethesda, Maryland, by NewsRx editors, research stated, "Premature infants are deprived of prenatal accumulation of brain docosahexaenoic acid [DHA (22: 6n-3)], an omega-3 fatty acid [omega-3 FA (n-3 FA)] important for proper development of cognitive function. The resulting brain DHA deficit can be reversed by omega-3 FA supplementation."
Our news journalists obtained a quote from the research from National Institute on Alcohol Abuse and Alcoholism, "The objective was to test whether there is a critical period for providing omega-3 FA to correct cognitive deficits caused by developmental omega-3 FA deprivation in mice. Twelve timed-pregnant mice [embryonic day 14 (E14), C57/BL6NCr] were fed an omega-3 FA-deficient diet containing 0.04% a-linolenic acid [ALA (18: 3n-3)], and their offspring were fed the same deficient diet (Def group) or changed to an omega-3 FA-adequate diet containing 3.1% ALA at 3 wk, 2 mo, or 4 mo of age. In parallel, 3 E14 pregnant mice were fed the adequate diet and their offspring were fed the same diet (Adeq group) throughout the experiment. Brain FA composition, learning and memory, and hippocampal synaptic protein expression were evaluated at 6 mo by gas chromatography, the Morris water maze test, and western blot analysis, respectively. Maternal dietary omega-3 FA deprivation decreased DHA by > 50% in the brain of their offspring at 3 wk of age. The Def group showed significantly worse learning and memory at 6 mo than those groups fed the adequate diet. These pups also had decreased hippocampal expression of postsynaptic density protein 95 (43% of Adeq group), Homer protein homolog 1 (21% of Adeq group), and synaptosome-associated protein of 25 kDa (64% of Adeq group). Changing mice to the adequate diet at 3 wk, 2 mo, or 4 mo of age restored brain DHA to the age-matched adequate concentration. However, deficits in hippocampal synaptic protein expression and spatial learning and memory were normalized only when the diet was changed at 3 wk."
According to the news editors, the research concluded: "Developmental deprivation of brain DHA by dietary omega-3 FA depletion in mice may have a lasting impact on cognitive function if not corrected at an early age."
For more information on this research see: Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice. Journal of Nutrition, 2017;147(9):1624-1630. Journal of Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nutrition - www.hindawi.com/journals/jnume/)
Our news journalists report that additional information may be obtained by contacting H.Y. Kim, NIAAA, Lab Mol Signaling, National Institutes of Health, Bethesda, MD 20892, United States. Additional authors for this research include A. Desai, K. Kevala, J.W. Lee and L.E. Lozada (see also Proteomics).
Keywords for this news article include: Bethesda, Maryland, United States, North and Central America, Protein Expression, Proteomics, National Institute on Alcohol Abuse and Alcoholism.
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