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Investigators at Tehran University of Medical Sciences Release New Data on Acute Myeloid Leukemia (High Prevalence of Vitamin D Deficiency in Newly...

Hematology Week

10-20-17

Investigators at Tehran University of Medical Sciences Release New Data on Acute Myeloid Leukemia (High Prevalence of Vitamin D Deficiency in Newly Diagnosed Acute Myeloid Leukemia Patients and Its Adverse Outcome)

By a News Reporter-Staff News Editor at Hematology Week -- A new study on Oncology - Acute Myeloid Leukemia is now available. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "Although several studies have supported a preventive and therapeutic role of vitamin D (Vit D) for different types of cancers, we face insufficient documentation in acute myeloid leukemia (AML). So, we examined whether the serum calcidiol (25(OH)D) levels at the time of induction therapy have any impact on response and relapse in AML patients."

The news reporters obtained a quote from the research from the Tehran University of Medical Sciences, "Blood samples were collected from 65 patients on days 0 and 28 of treatment to evaluate serum concentration of 25(OH)D and its effects on complete remission (CR) achievement, relapse rate and hospitalization length. Of the 65 patients who were included in the study, 38 were male (58.5%) and 27 were female (41.5%). Median age at the time of treatment was 37 years (range 15-68). 6% of the participants were older than 60 years. In regard to 25(OH)D levels, 81.5% of AML patients were deficient (levels <20 ng/ml). There was a significant difference in CR between patients with sufficient and deficient level of 25(OH)D. Deficient patients had longer length of hospitalization than those with sufficient levels. Also Vitamin D deficient patients had higher serum ALP levels. The mean level of 25(OH)D on treatment day 28 in our study was significantly lower than the baseline value. The results of the study showed that serum 25(OH)D levels deficiency was highly prevalent among Iranian AML patients."

According to the news reporters, the research concluded: "Furthermore, higher Vit D levels in AML patients were associated with better outcome in these patients."

For more information on this research see: High Prevalence of Vitamin D Deficiency in Newly Diagnosed Acute Myeloid Leukemia Patients and Its Adverse Outcome. International Journal of Hematology-oncology and Stem Cell Research, 2017;11(3):209-216 (see also Oncology - Acute Myeloid Leukemia).

Our news correspondents report that additional information may be obtained by contacting F. Seyedalipour, Clinical Pharmacy Department, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Additional authors for this research include A. Mansouri, M. Vaezi, K. Gholami, K. Heidari, M. Hadjibabaie and A. Ghavamzadeh.

Keywords for this news article include: Iran, Asia, Tehran, Oncology, Hematology, Avitaminosis, Malnutrition, Patient Care, Hospitalization, Nutrition Disorders, Vitamin D Deficiency, Acute Myeloid Leukemia, Deficiency Diseases and Conditions, Nutritional and Metabolic Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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