High Vitamin D levels in childhood may cut diabetes risk
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Type 1 diabetes is a chronic autoimmune disease that is increasing by 3-5 per cent annually worldwide and occurs when the body's immune system destroys its own insulin-producing beta cells in the pancreas.
Islet autoimmunity, detected by antibodies that appear when the immune system attacks the islet cells in the pancreas that produce insulin, is a precursor to Type 1 diabetes.
Vitamin D represents a candidate protective factor for Type 1 diabetes as it regulates the immune system and autoimmunity, the researchers said.
"For several years there has been controversy among scientists about whether Vitamin D lowers the risk of developing of islet autoimmunity and Type 1 diabetes," said lead author
In the study, published in the journal Diabetes, the team searched for triggers and protective factors in 8,676 children with elevated Type 1 diabetes risk.
They identified islet autoimmunity in 376 children and compared them with 1,041 children who did not.
Among children who were at an increased genetic risk for Type 1 diabetes, those with lower Vitamin D levels in infancy and childhood went on to develop islet autoimmunity compared with those who did not develop autoimmunity.
The study showed that higher childhood vitamin D levels are significantly associated with a decreased risk of islet autoimmunity.