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Studies Conducted at Kaohsiung Medical University on Hypertension Recently Reported (Resveratrol prevents the combined maternal plus postweaning...

Cardiovascular Week

10-27-17

Studies Conducted at Kaohsiung Medical University on Hypertension Recently Reported (Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring)

By a News Reporter-Staff News Editor at Cardiovascular Week -- Research findings on Cardiovascular Diseases and Conditions - Hypertension are discussed in a new report. According to news reporting originating from Kaohsiung, Taiwan, by NewsRx correspondents, research stated, "Maternal high-fat (HF) diet is believed to induce oxidative stress and activate nutrient-sensing signals, which increase the risk of adult offspring to develop hypertension. We investigated whether resveratrol prevents the combined maternal plus postweaning HF-diets-induced hypertension in adult male offspring, with a focus on the kidney."

Our news editors obtained a quote from the research from Kaohsiung Medical University, "Female Sprague-Dawley rats received either a normal diet (ND) or HF diet (D12331, Research Diets) for 5 weeks before mating and during gestation and lactation. The male offspring were placed on either the ND or HF diet from weaning to 4 months of age, resulting in four experimental groups (maternal diet/postweaning diet; n=8-10/group): ND/ND, ND/HF, HF/ND and HF/HF. Another group of HF/HF rats (n=10) was treated with 0.5% resveratrol in drinking water between 2 and 4 months of age (HF/HF+R). Rats were killed at 4 months of age. We found that HF/HF-induced hypertension in adult offspring was prevented by resveratrol. Resveratrol mediated its protective effect on HF/HF-induced hypertension in the kidneys of male offspring by diminishing oxidative stress; reducing renal asymmetric dimethylarginine levels; mediating the renin-angiotensin system (RAS) in favor of vasodilatation; restoring nutrient-sensing pathways via increased levels of silent information regulator transcript 1 (SIRT1), AMP-activated protein kinase 2 alpha and peroxisome proliferator-activated receptor gamma coactivator 1-alpha; and inducing autophagy. Our data implicated an association between oxidative stress, RAS, nitric oxide, and nutrient-sensing signals in HF/HF-induced hypertension."

According to the news editors, the research concluded: "Resveratrol, acting as an antioxidant as well as a SIRT1 activator, might be a therapeutic approach for hypertension."

For more information on this research see: Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring. Journal of Nutritional Biochemistry, 2017;48():120-127. Journal of Nutritional Biochemistry can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Journal of Nutritional Biochemistry - www.journals.elsevier.com/journal-of-nutritional-biochemistry/)

The news editors report that additional information may be obtained by contacting C.N. Hsu, Kaohsiung Medical University, Sch Pharm, Kaohsiung, Taiwan. Additional authors for this research include Y.J. Lin, J.M. Sheen, I.C. Lin, H.R. Yu, L.T. Huang and Y.L. Tain (see also Cardiovascular Diseases and Conditions - Hypertension).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.jnutbio.2017.06.007. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Kaohsiung, Taiwan, Asia, Cardiovascular Diseases and Conditions, Hypertension, Kaohsiung Medical University.

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