Anti-cancer drugs could help prevent the hardening of blood vessels which cause heart attack and stroke
The new research, funded by the
Scientists from the University of Sheffields
As the blood swirls around at these junctions and bends, the disrupted flow is sensed by the walls of the arteries. This leads to inflammation and surface damage, which provides a foothold for fatty deposit to build up.
The researchers have shown this response is triggered by a protein called hypoxia-inducible factor (HIF), which controls cell metabolism and is known to have a role in some types of cancer.
Drugs that target HIF are already in clinical trials for the treatment of cancer, but this new research suggests they could be repurposed to prevent atherosclerosis.
That would save us having to develop something from scratch, and means were that bit nearer to treatments that doctors and patients will be able to benefit from.
The bends and branches in our blood vessels are completely normal but we tend to find this is where fatty deposits are most likely to build up. We now have an explanation for this, along with the potential to develop treatments that prevent atherosclerosis.
As research reveals more of what goes on in our blood vessels to allow fatty plaques to develop, we can find ways to prevent this build-up. Its too early to say for certain, but treatments targeting HIF might one day allow us to do this.
The study is published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) today (25 October 2017).