New Clinical Trials and Studies Study Findings Have Been Reported from Hubei University of Chinese Medicine (A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction)
By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Clinical Research - Clinical Trials and Studies. According to news reporting out of Hubei, People's Republic of China, by NewsRx editors, research stated, "Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated and."
Our news journalists obtained a quote from the research from the Hubei University of Chinese Medicine, "IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 mM resveratrol and the high dose group showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR."
According to the news editors, the research concluded: "Resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic."
For more information on this research see: A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Oncotarget, 2017;8(39):65717-65729 (see also Clinical Research - Clinical Trials and Studies).
Our news journalists report that additional information may be obtained by contacting J. Li, Key Laboratory of Ministry of Education on Traditional Chinese Medicine Resource and Compound Prescription, Hubei University of Chinese Medicine, Wuhan 430065, Hubei, People's Republic of China. Additional authors for this research include C.X. Zhang, Y.M. Liu, K.L. Chen and G. Chen.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.18632/oncotarget.20084. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Asia, Hubei, Clinical Research, Diet and Nutrition, Caloric Restriction, People's Republic of China, Clinical Trials and Studies.
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