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Study Results from Department of Nutrition in the Area of Multiple Sclerosis Reported (25-Hydroxyvitamin D deficiency and risk of MS among women in...

Health & Medicine Week

10-27-17

Study Results from Department of Nutrition in the Area of Multiple Sclerosis Reported (25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Autoimmune Diseases and Conditions - Multiple Sclerosis have been published. According to news originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "To determine whether and to what extent vitamin D deficiency is associated with multiple sclerosis (MS) risk. We conducted a prospective nested case-control study among women in the Finnish Maternity Cohort (FMC)."

Our news journalists obtained a quote from the research from the Department of Nutrition, "The FMC had 1.8 million stored serum samples taken during the pregnancies of over 800,000 women at the time of this study. Through linkages with hospital and prescription registries, we identified 1,092 women with MS diagnosed between 1983 and 2009 with at least 1 serum sample collected prior to date of MS diagnosis; >= 2 serum samples were available for 511 cases. Cases were matched to up to 3 controls (n = 2,123) on date of birth (+/- 2 years) and area of residence. 25-Hydroxyvitamin D (25[OH] D) levels weremeasured using a chemiluminescence assay. We used conditional logistic regression adjusted for year of sample collection, gravidity, and parity to estimate relative risks (RRs) and 95% confidence intervals (CIs). A 50 nmol/L increase in 25(OH) D was associated with a 39% reduced risk of MS (RR 0.61, 95% CI 0.44-0.85), p=0.003. Women with 25(OH) D levels <30 nmol/L had a 43% higherMSrisk (RR 1.43, 95% CI 1.02-1.99, p=0.04) as compared to women with levels >= 50 nmol/L. In women with >= 2 samples, MS risk was 2-fold higher in women with 25(OH) D< 30 nmol/L as compared to women with 25(OH) D>= 50 nmol/L (RR 2.02, 95% CI 1.18-3.45, p = 0.01)."

According to the news editors, the research concluded: "These results directly support vitamin D deficiency as a risk factor for MS and strengthen the rationale for broad public health interventions to improve vitamin D levels."

For more information on this research see: 25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort. Neurology, 2017;89(15):1578-1583. Neurology can be contacted at: Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Lippincott Williams and Wilkins - www.lww.com; Neurology - neurology.org)

The news correspondents report that additional information may be obtained from K.L. Munger, Harvard TH Chan Sch Public Hlth, Dept. of Nutr, Boston, MA 02115, United States. Additional authors for this research include K. Hongell, J. Aivo, M. Soilu-Hanninen, H.M. Surcel and A. Ascherio (see also Autoimmune Diseases and Conditions - Multiple Sclerosis).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1212/WNL.0000000000004489. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Boston, Massachusetts, United States, North and Central America, Autoimmune Diseases and Conditions, Risk and Prevention, Multiple Sclerosis, Department of Nutrition.

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