Researchers from Department of Cellular and Molecular Medicine Discuss Findings in Neurodegenerative Diseases and Conditions (Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired ...)
By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators discuss new findings in Neurodegenerative Diseases and Conditions. According to news reporting originating in Ottawa, Canada, by NewsRx journalists, research stated, "Mitochondrial dysfunction is a common feature of many genetic disorders that target the brain and cognition. However, the exact role these organelles play in the etiology of such disorders is not understood."
The news reporters obtained a quote from the research from the Department of Cellular and Molecular Medicine, "Here, we show that mitochondrial dysfunction impairs brain development, depletes the adult neural stem cell (NSC) pool and impacts embryonic and adult neurogenesis. Using deletion of the mitochondrial oxidoreductase AIF as a genetic model of mitochondrial and neurodegenerative diseases revealed the importance of mitochondria in multiple steps of the neurogenic process. Developmentally, impaired mitochondrial function causes defects in NSC self-renewal, neural progenitor cell proliferation and cell cycle exit, as well as neuronal differentiation. Sustained mitochondrial dysfunction into adulthood leads to NSC depletion, loss of adult neurogenesis and manifests as a decline in brain function and cognitive impairment."
According to the news reporters, the research concluded: "These data demonstrate that mitochondrial dysfunction, as observed in genetic mitochondrial and neurodegenerative diseases, underlies the decline of brain function and cognition due to impaired stem cell maintenance and neurogenesis."
For more information on this research see: Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Human Molecular Genetics, 2017;26(17):3327-3341. (Oxford University Press - www.oup.com/; Human Molecular Genetics - hmg.oxfordjournals.org)
Our news correspondents report that additional information may be obtained by contacting M. Khacho, Dept. of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, ON K1H 8M5, Canada. Additional authors for this research include A. Clark, D.S. Svoboda, J.G. MacLaurin, D.C. Lagace, D.S. Park and R.S Slack (see also Neurodegenerative Diseases and Conditions).
Keywords for this news article include: Ottawa, Canada, Ontario, Neurology, Neurogenetics, Adult Neurogenesis, Stem Cell Research, North and Central America, Neurodegenerative Diseases and Conditions.
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