New Acarbose Therapy Data Have Been Reported by Investigators at Dalian University of Technology (Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention)
By a News Reporter-Staff News Editor at Food Weekly News -- Researchers detail new data in Drugs and Therapies - Acarbose Therapy. According to news reporting originating from Liaoning, People's Republic of China, by VerticalNews correspondents, research stated, "Baicalein, a major component in Scutellaria baicalensis and Oroxylum indicum, is used as dietary supplement in Asia. In this study, we characterized the insulin-sensitizing activity of baicalein and found that baicalein improved insulin resistance by reducing the expression of SOCS3, increasing the phosphorylation of IRS1 and Aktl, reducing the phosphorylation of GSK3 and increasing hepatic glycogen level."
Funders for this research include National Natural Science Foundation of China, Important National Science & Technology Specific Projects of Novel Drug Discovery of the PR China, Fundamental Research Funds for the Central Universities, Open Fund of Key Laboratory of Biotechnology and Bioresources Utilization, State Ethnic Affairs Commission & Ministry of Education, China.
Our news editors obtained a quote from the research from the Dalian University of Technology, "We further evaluated the preventive effect of baicalein combined with acarbose in mice, aiming to enhance the therapeutic effect and reduce the side-effects of acarbose. The combination reduced the relative risk of progression from prediabetes to diabetes by 83.3% and the dose of acarbose by 80%. The underlying mechanisms include reducing postprandial hyperglycemia, improving insulin resistance, improving lipid metabolism, and reducing oxidative stress."
According to the news editors, the research concluded: "Our results suggest that the consumption of 195-780 mg/d baicalein might improve the efficacy of acarbose on diabetes prevention and reduce the side-effects of acarbose in long-term acarbose users."
For more information on this research see: Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention. Journal of Functional Foods, 2017;37():339-353. Journal of Functional Foods can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Functional Foods - www.journals.elsevier.com/journal-of-functional-foods/)
The news editors report that additional information may be obtained by contacting Y.S. Dong, Dalian University of Technology, Sch Life Sci & Biotechnol, Dalian 116024, Liaoning, People's Republic of China. Additional authors for this research include J. Sun, B.W. Zhang, Y. Xing, X.X. Yu, X. Li, Z.L. Xiu and W.L. Sun.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.jff.2017.08.005. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Liaoning, People's Republic of China, Asia, Nutritional and Metabolic Diseases and Conditions, Endocrine System Diseases and Conditions, Glucose Metabolism Disorders, Alpha-glucosidase Inhibitors, Risk and Prevention, Drugs and Therapies, Antidiabetic Agents, Insulin Resistance, Diabetes Mellitus, Peptide Proteins, Peptide Hormones, Acarbose Therapy, Hyperinsulinism, Pharmaceuticals, Proinsulin, Dalian University of Technology.
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