Life Extension Update
|Life Extension Update Exclusive |
Iron imbalance associated with Parkinson’s disease
Dr Levenson, who is an associate professor of nutrition, food and exercise sciences at FSU's College of Human Sciences, stated, "We define our work here at the cellular level. Our primary research objective is to better understand how trace metal imbalances, which are associated with neuropsychiatric and neurodegenerative diseases, affect the molecular mechanisms that regulate gene expression."
Dr Levenson and colleague Mark Mattson of the National Institute on Aging fed healthy mice and mice at risk of Parkinson’s disease varying amounts of iron. They found that high levels of iron were associated with the onset of Parkinson’s-like symptoms such as tremors in healthy mice, and appeared to accelerate the disease in mice that had already developed it. Low levels of the mineral delayed the onset of symptoms and slowed the disease’s progress.
In healthy mice, reduced iron levels also decreased the neurotransmitter dopamine, whose diminishment in Parkinson’s disease is responsible for the disease’s symptoms. Nevertheless, elevated iron levels remain more dangerous than low levels in their ability to increase the onset and progression of Parkinson’s disease.
This study shows that both low and high levels of iron are associated with the genes and neuron suicide that lead to reduced dopamine production and Parkinson’s disease.
Iron overload can intensify Parkinson's disease. Not only do Parkinson's patients have low levels of natural antioxidants, such as glutathione and superoxide dismutase, but they may also have high levels of iron in the substantia nigra area of the brain (Youdim et al. 1991; Good et al. 1992; Olanow 1993). Iron tends to catalyze free-radical reactions that destroy dopamine-producing cells (Linert et al. 2000). Potential sources of iron are from inadvertent or accidental ingestion of iron supplements, drinking water, iron plumbing pipes, and cookware. In addition to the brain, target organs are the liver, cardiovascular system, and kidneys (Roberts 1999).
The symptoms of Parkinson's disease are attributed to a loss of brain cells in the basal ganglia (Clayman 1989). These cells produce the neurotransmitter dopamine. There also seem to be abnormalities in other parts of the brain and in the availability of other neurotransmitters, such as serotonin and norepinephrine (Adam et al. 1983; Kish et al. 1984; Stern et al. 1984; Taylor et al. 1986; Ring et al. 1994; Arahata 1999; Bohnen et al. 1999; Narabayashi 1999).
Supplementation with nutrients has reported benefits for persons with Parkinson's disease. These supplements include amino acids, antioxidants, coenzyme Q10, melatonin, folic acid, acetyl-L-carnitine, octacosanol, phosphatidylserine, NADH, and the European drug Hydergine (Snider 1984; Yapa 1992; Mizuta et al. 1993; Schulz et al. 1995; 1996; Shults et al. 1997; 1998; 1999; Beal et al. 1998; Golbe et al. 1998; Sakagami et al. 1998; Seitz et al. 1998; Beal 1999; Jimenez-Jimenez et al. 2000; Kidd 2000; Nadlinger et al. 2001; Roghani et al 2001; Ross 2001; Tan et al. 2001; Zisapel 2001; Antolin et al. 2002; Chen et al. 2002; Duan et al. 2002).
Drugs such as L-dopa alleviate symptoms of Parkinson's disease but are not believed to slow the underlying disease process. A recent study found evidence that CoQ10 may help stop the specific brain cell death that causes Parkinson's (Shults et al. 2002).
The brain also needs a tremendous amount of energy to function properly. And, since coQ10 is one of the most efficient mitochondrial energy enhancers, it is logical to expect that this energy-enhancing nutrient could play a role in brain function.
It is a fact that coQ10 diminishes with age. This means mitochondrial energy decreases accordingly, leading to what is now being referred to as "mitochondrial disorders" or simply put, suboptimal health, as cellular energy and function are compromised.
L-tyrosine can be converted by neurons in the brain to dopamine and norepinephrine (noradrenaline), hormones, which are depleted by stress, overwork and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. Because of the liver conversion necessary for L-phenylalanine to have these effects, L-tyrosine is often faster acting. In addition, the conversion step from L-tyrosine to norepinephrine may be enhanced if the cofactors (vitamins B6 and C) are included.
Questions? Comments? Send them to email@example.com or call 954 766 8433 extension 7716.
For longer life,
Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp
Help spread the good news about living longer and healthier. Forward this email to a friend!
View previous issues of Life Extension Update in the Newsletter Archive.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
**This offer good one time only. Shipping fees, Life Extension Magazine® subscriptions, CHOICE and Premier program fees, and purchases made with LE Dollars or gift cards do not count toward your order total. Your purchase must total $100 or more in a single order for the $10 discount to apply. Standard shipping and handling (regularly $5.50) in the U.S., includes Alaska and Hawaii.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.