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Hypothermia and coQ10 improve cardiac arrest survival
Hypothermia has been recently demonstrated in clinical trials to reduce nerve cell damage and improve survival after cardiopulmonary rescuscitation (CPR). It is believed to protect the brain by reducing oxygen consumption and slowing the erelase of excitotoxic neurotransmitters and reactive oxygen species. Coenzyme Q10 is a compound made in the body that decreases with age, and has also been shown to have a neuroprotective and cardioprotective benefit.
In the current study, 25 patients received 250 milligrams liquid coQ10 eight hours after cardiac arrest and CPR, followed by 150 milligrams coQ10 three times per day for five days, and 24 patients received a placebo solution. All participants underwent 24 hours of hypothermia during which their core temperature was maintained at 35 degrees Celsius.
After three months, seventeen of the 25 subjects who received coenzyme Q10 were alive compared to 7 who received the placebo. Thirty-six percent of the group who received coQ10 were considered to have a good neurologic outcome compared to 20 percent of the placebo group. Additionally, S100 protein, a marker for cerebral injury, was significantly lower in the group who received coQ10. No adverse effects were attributed to coQ10 administration.
In the discussion of their findings, the authors remark that the optimal dose of coenzyme Q10 per day is uncertain, and note that 1200 milligrams per day provided greater neuroprotection than 600 milligrams per day in the trial of coQ10 in Parkinson’s disease patients. They suggest future trials in which coQ10 is combined with other neuroprotective agents, such as those that target inflammatory pathways.
The following examples exemplify the breadth of CoQ10's credits:
Coenzyme Q10 (CoQ10) has long been considered an essential nutrient for cardiac health because of its role in boosting cellular energy. When CoQ10 is orally administered, it works its way into the cells' mitochondria (the cells' powerhouses) where it helps to convert fats and sugars into energy. Thus, scientists have focused on its critical role in heart function. But, further studies have identified CoQ10's other important role: as a neuroprotective agent.
The brain also needs a tremendous amount of energy to function properly. And, since CoQ10 is one of the most efficient mitochondrial energy enhancers, it is logical to expect that this energy-enhancing nutrient could play a role in brain function.
It is a fact that CoQ10 diminishes with age. This means mitochondrial energy decreases accordingly, leading to what is now being referred to as "mitochondrial disorders" or simply put, sub-optimal health, as cellular energy and function are compromised.
CoQ10 is an essential component of the respiratory cycle of the cell that takes place in the mitochondria and generates ATP, the cell’s energy currency.
Orally administered CoQ10 goes directly to the mitochondria where it works to regulate the oxidation of fats and sugars into energy—an important function since the natural production of CoQ10 declines with advancing age. When the body has an ample amount of CoQ10 the mitochondria can work most efficiently throughout the entire body, in cells everywhere, including the most densely populated area, the heart.
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