Life Extension Update
|April 19, 2004|
|Life Extension Update Exclusive |
Better than testosterone?
One hundred twenty men between the ages of 60 and 74 with symptoms of low testosterone were randomized to receive 160 milligrams orally administered testosterone undecanoate, 2 grams propionyl-L-carnitine plus 2 grams acetyl-L-carnitine per day, or a placebo for a six month period. Prostate-specific antigen, prostate volume, nocturnal penile tumescence, total and free testosterone, prolactin, luteinizing hormone, erectile function scores, depression, fatigue and other parameters were assessed before treatment, at three months, and after the treatment period.
Erectile function, sexual desire, sexual satisfaction and nocturnal penile tumescence increased over the course of the study in the group receiving testosterone as well as the group receiving carnitine. In addition, the group receiving carnitine experienced an increase in orgasm and general sexual well-being. Erectile function and nocturnal penile tumescence were significantly more improved in this group than in those receiving testosterone. While both treatments lowered depression scores, carnitine’s effect was greater.
Predictably, treatment with testosterone increased serum total and free testosterone and decreased luteinizing hormone levels, but carnitine’s effect on these hormones was not significant. Treatment with carnitine was not associated with an increase in prostate volume as was testosterone treatment after six months. PSA levels did not increase in any of the groups.
Although tissue carnitine levels have been found to be positively associated with sex hormone levels, the findings of this study show that the compound’s action is not strictly linked to sex hormone blood levels. Carnitine’s mechanism of action against reactive oxygen species (ROS) is different than conventional anti-ROS compounds tried for conditions associated with male aging, which may help explain its effectiveness.
Male Hormone Modulation
Before beginning testosterone replacement, comprehensive blood testing is necessary to determine liver-kidney function, and levels of glucose, minerals, lipids, thyroid, free and total testosterone, estadiol, DHT, DHEA, PSA, homocysteine, LH (optional), and SHBG (optional). These tests may be done at your doctor's office or they can be performed directly at a laboratory in your area. Call 1-800-208-3444 for information about ordering these tests on your own. A digital rectal exam is also recommended to eliminate the possibility of prostate cancer. Natural testosterone is highly recommended over synthetic types. Nutritional supplements may be added to the diet depending upon test results that can prevent testosterone from cascading into estrogen and DHT.
The following supplements are recommended:
A major cause of aging is the deterioration of the energy-producing components of the cell which results in reduced cellular metabolic activity, the accumulation of cellular debris, and eventual death of the cell.
The amino acid L-carnitine helps to maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria within the cell, where these fats are oxidized to produce the cellular energy ATP.
As you grow older, the testosterone responsible for libido tends to bind to globulins in the blood instead of stimulating cell receptor sites throughout the body. Natural plant extracts have been shown to enhance sexual desire, performance, and gratification. These extracts also have been shown to be free of side effects. Life Extension offers a standardized muira puama extract combined with a potent nettle root extract, zinc, Peruvian ginseng (maca), and chrysin in a preparation called Super MiraForte. This product is for use by men only.
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