Life Extension Update
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Study finds DHA important for Alzheimer’s patients
For the current study, the UCLA team used mice bred to have the human version of a mutant amyloid precursor protein which produces the brain plaques characteristic of Alzheimer’s disease. Older animals who were already showing evidence of the Alzheimer’s lesions were fed omega-3 fatty acid depleted diets while another group of the same age was given the diet supplemented with DHA derived from algae. Two additional groups of mice who did not have the Alzheimer’s gene were provided with regimens identical to those of the treatment groups.
When the animals were examined after five months, the researchers found significant damage to the synapses of the nerve cells in the brains of the mice with Alzheimer’s disease who were on DHA deficient diet. (Synapses are the connections between nerve cells through which the cells communicate.) The changes were similar to those observed in the brains of human Alzheimer's disease patients. Supplementation with DHA helped prevent this damage, as well as providing protection against oxidative stress in the mice who received it.
In studies in which behavior was examined, the mutant mice who received low-DHA diets showed deficits in memory and learning that did not occur in mice supplemented with DHA.
The authors explained their findings by noting that oxidative stress is the probable cause of the loss of DHA, which can be controlled by increased intake of the fatty acid and should be reduced by dietary or supplementary antioxidants.
Dr Cole commented, "This is the first proof that our diets affect how our brain cells communicate with each other under the duress of Alzheimer's disease. We saw that a diet rich in DHA, or docosahexaenoic acid, dramatically reduces the impact of the Alzheimer's gene. Consuming more DHA is something the average person can easily control. Anyone can buy DHA in its purified form, fish-oil capsules, high-fat fish or DHA-supplemented eggs."
Dr Cole and colleagues conclude that the results of their research, “support the idea that increased DHA intake should be considered as a potential neuroprotective strategy for AD." (Calon F, L GP, Yang F et al, “Docosahexaenoic acid protects from dendritic pathology in an Alzheimer’s disease mouse model,” Neuron, vol 43, 633-645.)
Free-radical damage (oxidative stress) is a significant cause of biological aging. It is well-known that neurons are extremely sensitive to attacks by destructive free radicals. The following evidence supports the hypothesis of free-radical damage being a central cause in Alzheimer's disease (Christen 2000):
Omega-3 fatty acids that are found in cold water fish (and fish oil) and perilla and flaxseed oils, have the ability to suppress the production of inflammatory mediators. Omega-3 oils contain the essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can be lacking in the typical Western diet that includes a high amount of omega-6 fats.
Phosphatidylcholine (PC), a major structural component of brain cells, is important for intelligence and memory. Ginkgo functions via many mechanisms to maintain healthy neurological function. This supplement combines these two widely documented brain-boosting nutrients into one capsule. Also included, are medium chain triglycerides (MCT) —saturated fatty acids that do not induce cholesterol formation, are burned as fuel, and have shown significant health benefits.
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