Life Extension Update
|Life Extension Update Exclusive |
Long term calcium supplement use equals long term protection
The current study followed participants from the Calcium Polyp Prevention Study, which found a 19 percent reduction in polyp formation and a 28 percent reduction in the development of advanced adenomas among patients with a history of developing polyps who received a 1200 milligram daily calcium supplement for four years compared to those who received a placebo. In the Calcium Follow Up Study, Maria Grau MD of the Section of Biostatistics and Epidemiology at Dartmouth and colleagues tracked polyp formation and analyzed the effect of additional calcium supplements among 822 subjects from the original study.
They found that even after adjusting for the use of calcium supplements following the end of the original study, subjects who had received calcium during the trial experienced a 36 percent reduction in the development of new polyps in the five years that followed. For a type of polyp called nonneoplastic hyperplastic polyps, there was a 48 percent reduction. However, during the entire follow-up period, which was a great as ten years for some participants, the protective effect declined, although those who received supplements during the study still had a 19 percent lower risk of polyp development.
Dr Grau concluded, "This provides further evidence of the potential of calcium to be used as a chemopreventive agent against development of colorectal cancer."
Fiber, particularly bran and cellulose appear to be effective in reducing the risk of colorectal carcinogenesis (the generation of cancer from normal cells) (Greenwald et al. 1986). Fruit fiber consumption, as opposed to vegetable fiber, reduced the risk of colorectal adenomas (Platz et al. 1997).
There is a direct relationship suggested by epidemiological studies between total fat intake in the diet and increased risk of cancer in the colon and rectum. Animal fat, particularly dairy products, and red meat are associated with colon cancer risk, whereas there is no association with vegetable fats, and fish oils appear to have a protective effect (Schloss et al. 1997). Lower cholesterol levels have been shown in patients diagnosed with colorectal cancer (Forones et al. 1998). Conversely, elevated levels of serum triglycerides have been associated with a higher risk of adenomatous polyps (Bird et al. 1996b).
Low selenium levels exist in patients prone to colon adenomas. In fact, reduced selenium levels are associated with the diagnosis of large size adenomatous polyps (Fernandez-Banares et al. 2002). In a double-blinded, placebo-controlled trial, patients with colon adenomas presented with low serum levels of selenium and plasma glutathione peroxidase (pGPx) activity before treatment, but with interventional selenium supplementation, both parameters were normalized (Al-Taie et al. 2003). Fortunately, cancer cells are more sensitive to the effects of selenium than their noncancerous counterparts.
Questions? Comments? Send them to email@example.com or call 954 202 7716.
For longer life,
Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp
Help spread the good news about living longer and healthier. Forward this email to a friend!
View previous issues of Life Extension Update in the Newsletter Archive.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
**This offer good one time only. Shipping fees, Life Extension Magazine® subscriptions, CHOICE and Premier program fees, and purchases made with LE Dollars or gift cards do not count toward your order total. Your purchase must total $100 or more in a single order for the $10 discount to apply. Standard shipping and handling (regularly $5.50) in the U.S., includes Alaska and Hawaii.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.