Life Extension Update
Omega-3 fatty acids improve heart attack survival in rats
The June, 2006 issue of the Journal of Nutrition published the findings of researchers at Indiana University-Purdue University in Indianapolis that consuming diets high in omega-3 polyunsaturated fatty acids (PUFAs) extends the period of survival in mice in whom heart attack was induced. Heart attacks are responsible for fifty percent of all cardiovascular deaths in the United States.
Seventy-four male rats who survived induced myocardial infarction via coronary artery ligation were divided to receive diets high in omega-3 or omega-6 fatty acids. The fat content of the high omega-3 diet consisted of 28 percent eicosapentaenoic and docosahexaenoic acids, while the high omega-6 diet provided 58 percent of its lipid content in the form of linoleic acid.
At six months, 33 of the rats on the high omega-3 diets were alive compared with 24 on the high omega-6 diets. Rats who died prior to six months appeared to be healthy, yet died from sudden death. Examination of plasma cardiac tissue from the surviving animals predictably showed higher levels of the polyunsaturated fatty acids from the diets they received. Total kinase activity was one-third lower in the group that received the high omega-3 than in the omega-6 group. Protein kinase pathways are associated with the generation of heart arrhythmias, which are the cause of most cases of sudden cardiac death.
The investigation is the first long-term dietary outcome study of sudden death utilizing a rat model of myocardial infarction. The authors speculate that “decreased activities of protein kinases induced by diets high in omega-3 PUFAs are associated with a decrease in sudden death after MI in rats.”
There are several kinds of arrhythmias, depending on the nature of the abnormal heart rhythm:
Sometimes arrhythmias are also identified by where in the heart they arise. For example, atrial fibrillation describes a chaotic, quivering rhythm that occurs in the upper chambers of the heart, or the atria.
Extensive scientific studies, both animal and human, have shown that supplementing the diet with fish and their oils has a beneficial effect on the heart, particularly in preventing cardiac arrhythmias (Nair SS et al 1997). The omega-3 fatty acids in fish oils appear to stabilize the electrical activity of the heart muscle, reducing susceptibility even to ventricular arrhythmias and ultimately decreasing the risk of sudden cardiac death (Lee KW et al 2003; Kang JX et al 2000).
The GISSI-Prevention study of more than 11,000 people taking a purified form of omega-3 fatty acids as a supplement has shown a significant decrease in the occurrence of sudden cardiac death among the participants (Lee KW et al 2003; De Caterina R et al 2002; Richter WO 2003). The efficacy of this preparation was greater than that of pravastatin, a commonly prescribed statin drug. Remarkably, the reduction in fatalities was seen even in patients who were already taking preventive medications such as aspirin and statin drugs (Lee KW et al 2003; Richter WO 2003). Beneficial effects may be seen within 90 days of starting omega-3 therapy and may continue progressively with longer use, leading to their recommendation as a “promising additional measure for secondary prevention” (Richter WO 2003).
Both magnesium and potassium are intricately involved in the heart’s electrical stability (Cybulski J et al 2004); consequently, maintaining normal functional blood levels and ratios of each is important. Potassium is found in every cell of the body, and magnesium, the second-most-abundant intracellular mineral, is involved in many chemical processes (Swain R et al 1999). Magnesium deficiency may result in irregular heartbeats, muscle weakness, and irritability.
Sloppy reporting, distorted editorial sensationalism, and conflicts of interest by researchers are unnecessarily alarming the public and threatening to destroy our trust in complementary health care. These injustices must be addressed before irreversible harm is done to an industry committed to natural approaches to wellness and to a public increasingly confused about where to turn for sound advice on preventing disease and achieving optimal health and well-being.
Questions? Comments? Send them to email@example.com or call 954 202 7716.
For longer life,
Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp
Help spread the good news about living longer and healthier. Forward this email to a friend!
View previous issues of Life Extension Update in the Newsletter Archive.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.