Life Extension Update
Friday, March 2, 2012. A research letter published in the February 27, 2012 issue of the American Medical Association journal Archives of Internal Medicine reported the results of a study of women with primary dysmenorrhea which found that a single high dose of oral vitamin D3 reduced pain over a two month period. Dysmenorrhea is characterized by painful uterine cramping which is often accompanied by nausea, vomiting, diarrhea, and other symptoms. The condition affects at least half of premenopausal girls and women, and can have a major impact on work and school attendance and performance.
Excessive uterine production of hormone-like substances known as prostaglandins is a major cause of dysmenorrhea, which is commonly treated with nonsteroidal anti-inflammatory drugs.
For the current trial, Antonio Lasco, MD, Antonino Catalano, MD and Salvatore Benvenga, MD of the University of Messina in Italy enrolled forty women between the ages of 18 and 40 who reported at least four painful periods over the previous six months and whose serum 25-hydroxyvitamin D levels were lower than 45 nanograms per milliliter. Twenty participants were administered 300,000 international units (IU) vitamin D3 five days before the beginning of their next menstrual cycle, while the remainder received a placebo. Pain symptoms were scored before treatment and at one and two months.
A correlation was observed at the beginning of the study between increased pain scores and reduced serum vitamin D levels. Women who received vitamin D reported a significant reduction in pain over two months compared to the placebo group. While 40 percent of subjects who received a placebo took nonsteroidal anti-inflammatory drugs for pain at least once over the course of the trial, none who received vitamin D reported needing the drugs. The greatest benefits were observed among those reporting the highest level of pain at the beginning of the study. The authors explain that vitamin D decreases proinflammatory cytokines and regulates the expression of genes involved in the prostaglandin pathway, reducing prostaglandin activity.
In an invited commentary in the journal, Elizabeth R. Bertone-Johnson, ScD and JoAnn E. Manson, MD note that it is important to determine how long a reduction in pain in association with a single dose of vitamin D would last. They note that "If 300 000 IU is required every 2 months, this would equate to approximately 5000 IU per day, considerably higher than the tolerable upper intake level set by the Institute of Medicine of 4000 IU/day."
"If these findings are confirmed in future randomized trials, vitamin D supplementation may become an important new treatment option for women who experience menstrual pain disorders" they conclude.
PEAK ATP® is a registered trademark of Technical Sourcing International, Inc. and is protected by U.S. Patent Nos. 5,227,371 and 5,049,372 and other patents pending.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.