Life Extension Update
Tuesday, July 17, 2012. In a study supported by Life Extension, recognized by the National Kidney Foundation, and published in Journal of Renal Nutrition, researchers at Baylor University in Texas evaluated the effects of fish oil ingestion in thirty-one patients with chronic kidney disease (CKD).
An important consideration in chronic kidney disease, a leading cause of disability in the United States, is excess production of proinflammatory factors called cytokines. These inflammatory factors are implicated in a variety of health conditions, including cardiovascular and joint health, as well as kidney health. Although numerous studies support the health benefits of the omega-3 fatty acids EPA and DHA found naturally in fish oil, the potential effects of supplementation with fish oil in chronic kidney disease have not been well characterized in the scientific literature.
The Baylor scientists conducted a double-blind, randomized, placebo-controlled trial in non-dialysis chronic kidney disease patients to evaluate a nutritional supplement vs. placebo upon a variety of proinflammatory parameters. The cytokines evaluated in the study included interleukin 1b (IL-1b) and interleukin 6 (IL-6). The active treatment group received fish oil containing 1,400 mg of EPA and 1,000 mg of DHA daily, along with olive fruit extract (600 mg daily), and sesame lignans (20 mg daily).
The researchers discovered that fish oil, olive fruit extract, and sesame lignans had a significant, beneficial effect upon the inflammatory cytokine IL-1b compared with placebo, with lower levels in the active treatment group. Interleukin-6 levels did not change significantly in chronic kidney disease patients during the short trial.
Future research to include larger numbers of patients as well as longer duration trials will help clarify the effects of nutritional supplementation upon inflammatory factors in chronic kidney disease over time.
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