Life Extension Update
Grape seed extract goes after aggressive cancer cells
Tuesday, January 22, 2013. An article published online on December 22, 2012 in the journal Cancer Letters reveals a potent effect for grape seed extract against colorectal cancer in experiments involving cultured cancer cells. The findings indicate a beneficial effect for grape seed extract that increases with higher stage cancer.
Molly Derry of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences in Aurora and her associates tested the effect of grape seed extract in colorectal cancer cell lines in various stages of disease. They observed an increase in several of grape seed extract's anticancer mechanisms in association with increasing cancer stage. The effect is in sharp contrast with that of chemotherapy, which becomes less potent in association with increased metastatic potential. No adverse effects from the compound occurred in healthy cells.
"We've known for quite a while that the bioactive compounds in grape seed extract selectively target many types of cancer cells," stated Derry, who is a doctoral candidate in University of Colorado Cancer Center researcher Rajesh Agarwal, PhD's laboratory. "This study shows that many of the same mutations that allow colorectal cancer cells to metastasize and survive traditional therapies make them especially sensitive to treatment with grape seed extract."
"It required less than half the concentration of grape seed extract to suppress cell growth and kill 50 percent of stage IV cells than it did to achieve similar results in the stage II cells," she remarked. "A colorectal cancer cell can have upwards of 11,000 genetic mutations – differences from the DNA in healthy cells. Traditional chemotherapies may only target a specific mutation and as cancer progresses more mutations occur. These changes can result in cancer that is resistant to chemotherapy. In contrast, the many bioactive compounds of grape seed extract are able to target multiple mutations. The more mutations a cancer presents, the more effective grape seed extract is in targeting them."
The discovery is of significance in view of the increased prevalence of colorectal cancer in Western societies, coupled with the fact that 60 percent of those diagnosed are at an advanced stage of cancer. "Finding a way to selectively target advanced colorectal cancer cells could have major clinical importance," Derry noted.
CoffeeGenic™ contains GCA™ which is a registered trademark of Applied Food Sciences, Inc. LuraLean® is a registered trademark of AHD International LLC.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
**This offer good one time only. Shipping fees, Life Extension Magazine® subscriptions, CHOICE and Premier program fees, and purchases made with LE Dollars or gift cards do not count toward your order total. Your purchase must total $100 or more in a single order for the $10 discount to apply. Standard shipping and handling (regularly $5.50) in the U.S., includes Alaska and Hawaii.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.