Life Extension Update
Vitamin D slows Parkinson's progression
Friday, March 22, 2013. The results of a double-blind, placebo-controlled trial reported online on March 13, 2013 in the American Journal of Clinical Nutrition reveal a benefit for vitamin D supplementation in men and women with Parkinson's disease.
In their introduction to the article, Masahiko Suzuki and his colleagues at Jikei University School of Medicine in Tokyo note that vitamin D levels are lower in Parkinson's disease patients. Supplementation with the vitamin has been found to reduce the risk of falling, which is higher among individuals with the disease. Studies have shown that variations in the vitamin D receptor gene are associated with Parkinson's disease risk.
For the current trial, 114 Parkinson's disease patients were randomized to receive 1200 international units (IU) vitamin D3 per day or a placebo for twelve months. Hoehn and Yahr stage, Unified Parkinson's Disease Rating Scale, Parkinson's Disease Questionnaire-39 and other tests were administered to assess disease status before and after treatment. Blood samples collected at enrollment were analyzed for factors that included 25-hydroxyvitamin D and calcium levels, and variations in genes associated with vitamin D binding protein and vitamin D receptor.
By the end of the study, Parkinson's disease stage worsened on average among those who received the placebo, but was essentially unchanged among those who received vitamin D. United Parkinson's Disease Rating Scale scores were similarly unchanged among vitamin D-supplemented participants, but worsened in the placebo group. Total Parkinson's Disease Questionnaire-39 scores improved on average among those who received vitamin D but were essentially unchanged among those who received the placebo. A significant benefit for vitamin D3 was observed among subjects with either of two vitamin D receptor FokI genotypes, but not among those with a third FokI genotype.
"To the best of our knowledge, this is the first randomized trial to examine the effects of vitamin D3 in patients with Parkinson's disease," the authors announce. "However, a meta-analysis showed that supplemental vitamin D for older adults who participated in randomized controlled trials consistently showed beneficial muscle effects on strength and balance. Therefore, it cannot be distinguished whether vitamin D supplementation specifically delays the progression of Parkinson's disease or whether it just nonspecifically improves muscle strength and balance in older adults."
The authors observe that the dose of vitamin D3 used in the study may have not been enough to maximize the effect of supplementation to improve Parkinson's disease, and that the number of participants may have been too few to detect small differences in some endpoints. However, they remark that "Even with these limitations, vitamin D prevented the deterioration of Parkinson's disease in this study."
AdipoStat is a proprietary ingredient derived from natural plant extracts exclusively distributed by InterHealth N.I. Integra-Lean® Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. IGOB-131® proprietary extract is a registered trademark of Gateway Health Alliances, Inc.
Pycnogenol® is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents. Supported by over 40 years of research.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
**This offer good one time only. Shipping fees, Life Extension Magazine® subscriptions, CHOICE and Premier program fees, and purchases made with LE Dollars or gift cards do not count toward your order total. Your purchase must total $100 or more in a single order for the $10 discount to apply. Standard shipping and handling (regularly $5.50) in the U.S., includes Alaska and Hawaii.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.