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Trauma and Wound Healing

References

Abdullahi A, Jeschke MC. 2014. Nutrition and Anabolic Pharmacotherapies in the Care of Burn Patients. Nutrition in Clinical Practice. 2014:621–30.

Adjepong M, Agbenorku P, Brown P, Oduro I. The Role of Antioxidant Micronutrients in the Rate of Recovery of Burn Patients: A Systematic Review. Burns & Trauma. 2016;4(1). https://burnstrauma.biomedcentral.com/articles/10.1186/s41038-016-0044-x.

Ahmed AA, Mooar PA, Kleiner M, Torg JS, Miyamoto CT. Hypertensive patients show delayed wound healing following total hip arthroplasty. PloS one. 2011;6(8):e23224.

Aird J, Noor S, Lavy C, Rollinson P. The effect of HIV on early wound healing in open fractures treated with internal and external fixation. The Journal of bone and joint surgery. British volume. May 2011;93(5):678-683.

Aiyegbusi AI, Duru FI, Anunobi CC, Noronha CC, Okanlawon AO. Bromelain in the Early Phase of Healing in Acute Crush Achilles Tendon Injury. Phytotherapy Research. 2011; 25(1):49–52.

Akbik D, Maliheh G, Wojciech C, Ramin R. Curcumin as a Wound Healing Agent. Life Sciences. 2014; 116(1):1–7.

AMR. Alternative Medicine Review. Monograph: Picorhiza kurroa. Copyright 2001 by Thorne Research, Inc. Vol. 6, No. 3. pp. 319-321. http://www.altmedrev.com/publications/6/3/319.pdf. 

Anaya DA, Dellinger EP. The obese surgical patient: a susceptible host for infection. Surg Infect (Larchmt). Oct 2006;7(5):473-480.

Anderson CA, Hare MA, Perdrizet GA. Wound Healing Devices Brief Vignettes. Advances in Wound Care (New Rochelle). 2016; 5(4):185-190.

Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Annals of plastic surgery. Jun 1997;38(6):563-576; discussion 577.

Armstrong DG, Hanft JR, Driver VR, et al. Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial. Diabet Med. Sep 2014;31(9):1069-1077.

Arnold M, Barbul A. Nutrition and wound healing. Plastic and reconstructive surgery. Jun 2006;117(7 Suppl):42s-58s.

Attinger CE, Bulan E, Blume PA. Surgical debridement. The key to successful wound healing and reconstruction. Clinics in podiatric medicine and surgery. Oct 2000;17(4):599-630.

Ayuk SM, Abrahamse H, Houreld NN. The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation. J Diabetes Res. 2016;2016:2897656.

Azad AK, Sermsintham N, Chandrkrachang S, Stevens WF. Chitosan Membrane as a Wound-Healing Dressing: Characterization and Clinical Application. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2004; 69(2):216–22.

Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y. Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials. Journal of Functional Biomaterials. 2015; 13(6):104-142.

Baker RD, Baker SS, LaRosa K, Whitney C, Newburger PE. Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B. Archives of biochemistry and biophysics. Jul 1993;304(1):53-57.

Barkey E, Kaszkin-Bettag M. A Homeopathic Arnica Patch for the Relief of Cellulitis-derived Pain and Numbness in the Hand. Glob Adv Health Med. May 2012;1(2):18-20.

Bellon G, Chaqour B, Wegrowski Y, Monboisse JC, Borel JP. Glutamine increases collagen gene transcription in cultured human fibroblasts. Biochimica et biophysica acta. Sep 21 1995;1268(3):311-323.

Biagini G, Bertani A, Muzzarelli R, Damadei A, DiBenedetto G, Belligolli A, Riccotti G, Zucchini C, Rizzoli C. Wound Management with N-Carboxybutyl Chitosan. Biomaterials. 1991;12(3):281–86.

Binić I, Janković A, Janković D, Janković I, Vrucinić Z. Evaluation of Healing and Antimicrobiological Effects of Herbal Therapy on Venous Leg Ulcer: Pilot Study. Phytotherapy Research. 2010;24(2):277-282.

Blass SC, Goost H, Tolba RH, Stoffel-Wagner B, Kabir K, Burger C, Stehle P, Ellinger S. Time to Wound Closure in Trauma Patients with Disorders in Wound Healing Is Shortened by Supplements Containing Antioxidant Micronutrients and Glutamine: A PRCT. Clinical Nutrition. 2012;31(4):469–75.

Block L, Gosain A, King TW. Emerging Therapies for Scar Prevention. Advances in wound care. Oct 01 2015;4(10):607-614.

Bouachour G, Cronier P, Gouello JP, Toulemonde JL, Talha A, Alquier P. Hyperbaric oxygen therapy in the management of crush injuries: a randomized double-blind placebo-controlled clinical trial. The Journal of trauma. Aug 1996;41(2):333-339.

Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clinical microbiology reviews. Apr 2001;14(2):244-269.

Brem H, Tomic-Canic M. Cellular and Molecular Basis of Wound Healing in Diabetes. The Journal of Clinical Investigation. 2007;117 (5):1219–22.

Breslow RA, Hallfrisch J, Guy DG, Crawley B, Goldberg AP. The importance of dietary protein in healing pressure ulcers. J Am Geriatr Soc. Apr 1993;41(4):357-362.

Brinkhaus B, Wilkens JM, Lüdtke R, Hunger J, Witt CM, Willich SN. Homeopathic Arnica Therapy in Patients Receiving Knee Surgery: Results of Three Randomised Double-Blind Trials. Complementary Therapies in Medicine. 2006;14(4):237–46.

Burgess C. Topical vitamins. J Drugs Dermatol. Jul 2008;7(7 Suppl):s2-6.

Burns J, Pieper B. HIV/AIDS: impact on healing. Ostomy/wound management. Mar 2000;46(3):30-40, 42, 44 passim; quiz 48-39.

Campos AC, Groth AK, Branco AB. Assessment and nutritional aspects of wound healing. Current opinion in clinical nutrition and metabolic care. May 2008;11(3):281-288.

Cardinal M, Eisenbud DE, Armstrong DG, et al. Serial surgical debridement: a retrospective study on clinical outcomes in chronic lower extremity wounds. Wound Repair Regen. May-Jun 2009;17(3):306-311.

CDC. Centers for Disease Control and Prevention. Surgical Site Infection (SSI) Event. https://www.cdc.gov/nhsn/pdfs/pscmanual/9pscssicurrent.pdf. January 2017. Accessed November 7, 2017.

Cereda E, Gini A, Pedrolli C, Vanotti A. Disease-Specific, Versus Standard, Nutritional Support for the Treatment of Pressure Ulcers in Institutionalized Older Adults: A Randomized Controlled Trial. Journal of the American Geriatrics Society. 2009;57(8):1395–1402.

Cisek AA, Dabrowska I, Gregorczyk KP, Wyzewski Z. Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages. Current Microbiology. 2017;74(2):277-283.

Clark A, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns & trauma. 2017;5:11.

Clinton A, Carter T. Chronic Wound Biofilms: Pathogenesis and Potential Therapies. Laboratory Medicine. 2015;46(4):277–84.

Coleridge-Smith P, Lok C, Ramelet AA. Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction. Eur J Vasc Endovasc Surg. Aug 2005;30(2):198-208.

Cornu C, Joseph P, Gaillard S, Bauer C, Vedrinne C, Bissery A, Melot G, Bossard N, Belon P, Lehot JJ. No Effect of a Homoeopathic Combination of Arnica Montana and Bryonia Alba on Bleeding, Inflammation, and Ischaemia after Aortic Valve Surgery. British Journal of Clinical Pharmacology. 2010;69(2):136–42.

Dai T, Tanaka M, Huang Y-Y, Hamblin MR. Chitosan Preparation for Wounds and Burns: Antimicrobial and Wound Healing Effects. Expert review of anti-infective therapy. 2011;9(7):857-879.

Daley BJ. Drugs & Diseases page. Wound Care Treatment & Management. https://emedicine.medscape.com/article/194018-treatment. Last updated 2/8/2017. Accessed 12/11/2017.

Dashty M, Akbarkhanzadeh V, Zeebregts CJ, Spek CA, Sijbrands EJ, Peppelenbosch MP, Rezaee F. Characterization of coagulation factor synthesis in nine human primary cell types. Sci Rep. 2012;2:787.

De Vries FE, Wallert ED, Solomkin JS, Allegranzi B, Egger M, Dellinger EP, Boermeester MA. A Systematic Review and Meta-Analysis Including GRADE Qualification of the Risk of Surgical Site Infections after Prophylactic Negative Pressure Wound Therapy Compared with Conventional Dressings in Clean and Contaminated Surgery. Medicine (Baltimore). 2016;95(36): e4673.

Demidova-Rice TN, Hamblin MR, Herman IM. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care. Advances in skin & wound care. Jul 2012;25(7):304-314.

Desneves KJ, Todorovic BE, Cassar A, Crowe TC. Treatment with Supplementary Arginine, Vitamin C and Zinc in Patients with Pressure Ulcers: A Randomised Controlled Trial. Clinical Nutrition. 2005;24(6):979-987.

Domenech M, Ramos-Sevillano E, Garcia E, Moscoso M, Yuste J. Biofilm formation avoids complement immunity and phagocytosis of Streptococcus pneumoniae. Infect Immun. Jul 2013;81(7):2606-2615.

Dreifke MB, Jayasuriya AA, Jayasuriya AC. Current Wound Healing Procedures and Potential Care. Materials Science & Engineering. C, Materials for Biological Applications. 2015;48:651–62.

Ellinger S. Micronutrients, Arginine, and Glutamine: Does Supplementation Provide an Efficient Tool for Prevention and Treatment of Different Kinds of Wounds? Advances in Wound Care (New Rochelle). 2014;3 11):691–707.

Emery CF, Kiecolt-Glaser JK, Glaser R, Malarkey WB, Frid DJ. Exercise Accelerates Wound Healing among Healthy Older Adults: A Preliminary Investigation. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2005;60(11):1432–36.

Eming SA, Martin P, Tomic-Canic M. Wound Repair and Regeneration: Mechanisms, Signaling, and Translation. Science Translational Medicine. 2014;6(265):265sr6.

Erinjeri JP, Fong AJ, Kemeny NE, Brown KT, Getrajdman GI, Solomon SB. Timing of administration of bevacizumab chemotherapy affects wound healing after chest wall port placement. Cancer. Mar 15 2011;117(6):1296-1301.

Escobar SJ, Slade JB, Jr., Hunt TK, Cianci P. Adjuvant hyperbaric oxygen therapy (HBO2) for treatment of necrotizing fasciitis reduces mortality and amputation rate. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. Nov-Dec 2005;32(6):437-443.

Eskes AM, Ubbink DT, Lubbers MJ, Lucas C, Vermeulen H. Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review. World Journal of Surgery. 2011;35(3):535–42.

Eskes A, Vermeulen H, Lucas C, Ubbink DT. Hyperbaric Oxygen Therapy for Treating Acute Surgical and Traumatic Wounds. Cochrane Database of Systematic Reviews. 2013;16(12):CD008059.

Espinoza SE, Guo H, Fedarko N, et al. Glutathione peroxidase enzyme activity in aging. J Gerontol A Biol Sci Med Sci. May 2008;63(5):505-509.

Fantuzzi G. Adipose tissue, adipokines, and inflammation. The Journal of allergy and clinical immunology. May 2005;115(5):911-919; quiz 920.

Fish R, Kutter E, Wheat G, Blasdel B, Kutateladze M, Kuhl S. Bacteriophage treatment of intransigent diabetic toe ulcers: a case series. Journal of wound care. Jul 2016;25 Suppl 7:S27-33.

Fish R, Kutter E, Wheat G, Blasdel B, Kutateladze M, Kuhl S. Bacteriophage Treatment of Intransigent Diabetic Toe Ulcers: A Case Series. Journal of Wound Care. 2016;25 (Suppl 7):S27–33.

Gardner SE, Frantz RA. Wound bioburden and infection-related complications in diabetic foot ulcers. Biological research for nursing. Jul 2008;10(1):44-53.

Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Molecular medicine (Cambridge, Mass.). Jan-Feb 2011;17(1-2):113-125.

Genton L, Pichard C. Protein catabolism and requirements in severe illness. Int J Vitam Nutr Res. Mar 2011;81(2-3):143-152.

Ghafouri HB, Bagheri-Behzad B, Yasinzadeh MR, Modirian E, Divsalar D, Farahmand S. Prophylactic Antibiotic Therapy in Contaminated Traumatic Wounds: Two Days versus Five Days Treatment. BioImpacts: BI. 2012;2(1):33-37.

Gibbons GW. Grafix®, a Cryopreserved Placental Membrane, for the Treatment of Chronic/Stalled Wounds. Advances in Wound Care (New Rochelle). 2015;4(9):534–44.

Gilliver SC, Ruckshanthi JP, Atkinson SJ, Ashcroft GS. Androgens Influence Expression of Matrix Proteins and Proteolytic Factors during Cutaneous Wound Healing. Laboratory Investigation. 2007;87(9):871–81

Godbout JP, Glaser R. Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer. Journal of Neuroimmune Pharmacology. 2006;1(4):421–27.

Goldman L, Schafer A. “Medical Aspects of Injuries and Burns.” In: Goldman-Cecil Medicine, 25th ed. 2016; pp.711–17. https://www.clinicalkey.com/#!/content/book/3-s2.0-B9781455750177001112.

Gonzalez AC, Costa TF, Andrade ZA, Medrado AR. Wound healing - A literature review. Anais brasileiros de dermatologia. Sep-Oct 2016;91(5):614-620.

Gosain A, DiPietro LA. Aging and Wound Healing. World Journal of Surgery. 2004;28(3):321–26.

Gouin JP, Kiecolt-Glaser JK. The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms. Immunology and Allergy Clinics of North America. 2012;24(2):201-213.

Gould L, Abadir P, Brem H, et al. Chronic wound repair and healing in older adults: current status and future research. J Am Geriatr Soc. Mar 2015;63(3):427-438.

Guo S, Dipietro LA. Factors affecting wound healing. Journal of dental research. Mar 2010;89(3):219-229.

Halim AS, Khoo TL, Saad AZ. Wound bed preparation from a clinical perspective. Indian journal of plastic surgery: official publication of the Association of Plastic Surgeons of India. May 2012;45(2):193-202.

Harold RE, Butler BA, Lamplot J, Luu HH, Lawton CD, Manning D. Multifaceted aseptic protocol decreases surgical site infections following hip arthroplasty. Hip international: the journal of clinical and experimental research on hip pathology and therapy. Sep 21 2017:0.

Harries RL, Bosanquet DC, Harding KG. Wound Bed Preparation: TIME for an Update. International Wound Journal. 2016;13 (Suppl 3):8–14.

Healy B, Freedman A. Infections. BMJ (Clinical research ed.). Apr 08 2006;332(7545):838-841.

Hellmann J, Tang Y, Spite M. Proresolving lipid mediators and diabetic wound healing. Curr Opin Endocrinol Diabetes Obes. Apr 2012;19(2):104-108.

Huang Y, Tang SR, Young CJ. Nonsteroidal anti-inflammatory drugs and anastomotic dehiscence after colorectal surgery: a meta-analysis. ANZ journal of surgery. Nov 22 2017.

Huijberts MS, Schaper NC, Schalkwijk CG. Advanced Glycation End Products and Diabetic Foot Disease. Diabetes/Metabolism Research and Reviews. 2008;24 (Suppl 1):S19–24.

Hyldig N, Birke-Sorensen H, Kruse M, Vinter C, Joergensen JS, Sorensen JA, Mogensen O, Lamont RF, Bille C. Meta-Analysis of Negative-Pressure Wound Therapy for Closed Surgical Incisions. The British Journal of Surgery. 2016;103(5):477–86.

Iannitti T, Morales-Medina JC, Bellavite P, Rottigni V, Palmieri B. Effectiveness and Safety of Arnica montana in Post-Surgical Setting, Pain and Inflammation. American journal of therapeutics. Jan-Feb 2016;23(1):e184-197.

Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med. Dec 1999;5(12):1418-1423.

Jones MS, Rivera M, Puccinelli CL, Wang MY, Williams SJ, Barber AE. Targeted Amino Acid Supplementation in Diabetic Foot Wounds: Pilot Data and a Review of the Literature. Surgical Infections (Larchmt). 2014;15(6):708–12.

Karna E, Miltyk W, Wolczynski S, Palka JA. The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. Aug 2001;130(1):23-32.

Keylock KT, Vieira VJ, Wallig MA, DiPietro LA, Schrementi M, Woods JA. Exercise Accelerates Cutaneous Wound Healing and Decreases Wound Inflammation in Aged Mice. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2008;294(1):R179-184.

Khairnar MS, Pawar B, Marawar PP, Mani A. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. J Indian Soc Periodontol. Nov 2013;17(6):741-747.

Khorasani G, Hosseinimehr SJ, Azadbakht M, Zamani A, Mahdavi MR. Aloe versus Silver Sulfadiazine Creams for Second-Degree Burns: A Randomized Controlled Study. Surgery Today. 2009;39(7):587–91.

Kiecolt-Glaser JK, Glaser R, Christian LM. Omega-3 fatty acids and stress-induced immune dysregulation: implications for wound healing. Military medicine. Nov 2014;179(11 Suppl):129-133.

Klein KC, Guha SC. Cutaneous wound healing: Current concepts and advances in wound care. Indian journal of plastic surgery: official publication of the Association of Plastic Surgeons of India. Sep-Dec 2014;47(3):303-317.

Koel G, Houghton PE. Electrostimulation: Current Status, Strength of Evidence Guidelines, and Meta-Analysis. Advances in Wound Care (New Rochelle). 2014;3(2):118–26.

Konig M, Vanscheidt W, Augustin M, Kapp H. Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomised trial. Journal of wound care. Jul 2005;14(7):320-323.

Kotlus BS, Heringer DM, Dryden RM. Evaluation of Homeopathic Arnica Montana for Ecchymosis After Upper Blepharoplasty: A Placebo-Controlled, Randomized, Double-Blind Study. Ophthalmic Plastic & Reconstructive Surgery. 2010;26(6):395–97.

Kyaw BM, Jarbrink K, Martinengo L, Car J, Harding K, Schmidtchen A. Need for Improved Definition of "Chronic Wounds" in Clinical Studies. Acta dermato-venereologica. Sep 07 2017.

Landi F, Calvani R, Tosato M, Martone AM, Ortolani E, Savera G, D’Angelo E, Sisto A, Marzetti E. Protein Intake and Muscle Health in Old Age: From Biological Plausibility to Clinical Evidence. Nutrients. 2016;8(5):pii: E295.

Lavery LA, Fulmer J, Shebetka KA, Regulski M, Vayser D, Fried D, Kashefsky H, Owings TM, Nadarajah J, Grafix Diabetic Foot Ulcer Study Group. The Efficacy and Safety of Grafix(®) for the Treatment of Chronic Diabetic Foot Ulcers: Results of a Multi-Centre, Controlled, Randomised, Blinded, Clinical Trial. International Wound Journal. 2014;11(5):554-560.

Leaper D, Assadian O, Edmiston CE. Approach to chronic wound infections. The British journal of dermatology. Aug 2015;173(2):351-358.

Lebeaux D, Ghigo JM, Beloin C. Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics. Microbiol Mol Biol Rev. Sep 2014;78(3):510-543.

Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M. Accelerated Resolution of Laser-Induced Bruising with Topical 20% Arnica: A Rater-Blinded Randomized Controlled Trial. The British Journal of Dermatology. 2010;163(3):557–63.

Li H, Jasper H. Gastrointestinal Stem Cells in Health and Disease: From Flies to Humans. Disease Models & Mechanisms. 2016;9(5):487–99.

Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and Biomarkers for Wound Healing. Plastic and Reconstructive Surgery. 2016;138 (3 Suppl):18S–28S.

MacKay D, Miller AL. Nutritional Support for Wound Healing. Alternative Medicine Review. 2003;8(4):359–77.

Mangoni ML, McDermott AM, Zasloff M. Antimicrobial Peptides and Wound Healing: Biological and Therapeutic Considerations. Experimental Dermatology. 2016;25(3):167–73.

McCallon SK, Weir D, Lantis JC, 2nd. Optimizing Wound Bed Preparation With Collagenase Enzymatic Debridement. The journal of the American College of Clinical Wound Specialists. Apr 2014;6(1-2):14-23.

Meaume S, Kerihuel JC, Constans T, Teot L, Lerebours E, Kern J, Bourdel Marchasson I. Efficacy and Safety of Ornithine Alpha-Ketoglutarate in Heel Pressure Ulcers in Elderly Patients: Results of a Randomized Controlled Trial. The Journal of Nutrition, Health & Aging. 2009;13(7):623–30.

Mecott GA, Al-Mousawi AM, Gauglitz GG, Herndon DN, Jeschke MG. The Role of Hyperglycemia in Burned Patients: Evidence-Based Studies. Shock. 2010;33(1):5–13.

Mercandetti M, Cohen AJ. Wound Healing and Repair. http://emedicine.medscape.com/article/1298129-overview. Last updated 5/29/2017. Accessed 12/8/2017.

Mo X, Cen J, Gibson E, Wang R, Percival SL. An Open Multicenter Comparative Randomized Clinical Study on Chitosan. Wound Repair and Regeneration. 2015;23(4):518–24.

Mohammed BM, Fisher BJ, Kraskauskas D, Ward S, Wayne JS, Brophy DF, Fowler AA 3rd, Yager DR, Natarajan R. Vitamin C Promotes Wound Healing through Novel Pleiotropic Mechanisms. International Wound Journal. 2016;13(4):572-584.

Molnar JA, Underdown MJ, Clark WA. Nutrition and Chronic Wounds. Advances in wound care. Nov 01 2014;3(11):663-681.

Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. Diabet Med. Apr 2008;25(4):419-426.

Murphy PS, Evans GR. Advances in Wound Healing: A Review of Current Wound Healing Products. Plastic Surgery International.2012;2012:190436.

Nicks BA, Ayello EA, Woo K, Nitzki-George D, Sibbald RG. Acute Wound Management: Revisiting the Approach to Assessment, Irrigation, and Closure Considerations. International Journal of Emergency Medicine. 2010;3(4):399–407.

Nigam Y, Morgan C. Does maggot therapy promote wound healing? The clinical and cellular evidence. J Eur Acad Dermatol Venereol. May 2016;30(5):776-782.

Nunan R, Harding KG, Martin P. Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Disease models & mechanisms. Nov 2014;7(11):1205-1213.

Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. May 01 2008;13:3532-3548.

Oryan A, Alemzadeh E. Effects of insulin on wound healing: A review of animal and human evidences. Life sciences. Mar 02 2017.

Otvos L Jr., Ostorhazi E. Therapeutic Utility of Antibacterial Peptides in Wound Healing. Expert Review of Anti-Infective Therapy. 2015;13(7):871-881.

Panahi Y, Izadi M, Sayyadi N, Rezaee R, Jonaidi-Jafari N, Beiraghdar F, Zamani A, Sahebkar A. Comparative Trial of Aloe Vera/olive Oil Combination Cream versus Phenytoin Cream in the Treatment of Chronic Wounds. Journal of Wound Care. 2015;24(10):459–60, 462–65.

Payne WG, Naidu DK, Wheeler CK, et al. Wound healing in patients with cancer. Eplasty. Jan 11 2008;8:e9.

Pence BD, Woods JA. Exercise, Obesity, and Cutaneous Wound Healing: Evidence from Rodent and Human Studies. Advances in Wound Care (New Rochelle). 2014;3(1):71–79.

Pence BD, DiPietro LA, Woods JA. Exercise Speeds Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice. Medicine & Science in Sports & Exercise. 2012;44(10):1846–54.

Percival SL, McCarty SM, Lipsky B. Biofilms and Wounds: An Overview of the Evidence. Advances in wound care. Jul 01 2015;4(7):373-381.

Pereira RF, Bártolo PJ. Traditional Therapies for Skin Wound Healing. Advances in Wound Care (New Rochelle). 2016;5(5):208–29.

Pories WJ, Henzel JH, Rob CG, Strain WH. Acceleration of Healing with Zinc Sulfate. Annals of Surgery. 1967;165(3):432–36.

Posthauer ME. What is the role of vitamins in wound healing? Advances in skin & wound care. May 2007;20(5):260, 263-264.

Pyter LM, Husain Y, Calero H, et al. Tumors Alter Inflammation and Impair Dermal Wound Healing in Female Mice. PloS one. 2016;11(8):e0161537.

Quain AM, Khardori NM. Nutrition in Wound Care Management: A Comprehensive Overview. Wounds: a compendium of clinical research and practice. Dec 2015;27(12):327-335.

Reichrath J, Lehmann B, Carlberg C, Varani J, Zouboulis CC. Vitamins as Hormones. Hormone and Metabolic Research. 2007;39(2):71–84.

Reyzelman AM, Vartivarian M. Evidence of Intensive Autolytic Debridement With a Self-Adaptive Wound Dressing. Wounds: a compendium of clinical research and practice. Aug 2015;27(8):229-235.

Rezvani O, Shabbak E, Aslani A, Bidar R, Jafari M, Safarnezhad S. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy/wound management. Aug 1 2009;55(8):22-28.

Rose T, Verbeken G, Vos DD, Merabishvili M, Vaneechoutte M, Lavigne R, Jennes S, Zizi M, Pirnay JP. Experimental Phage Therapy of Burn Wound Infection: Difficult First Steps. Int J Burn Trauma. 2014;4(2):66–73.

Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, Chan RK, Christy RJ, Chung KK. Burn Wound Healing and Treatment: Review and Advancements. Critical Care. 2015;19:243.

Rucker RB, Kosonen T, Clegg MS, Mitchell AE, Rucker BR, Uriu-Hare JY, Keen CL. Copper, lysyl oxidase, and extracellular matrix protein cross-linking. The American journal of clinical nutrition. May 1998;67(5 Suppl):996s-1002s.

Saito T, Tazawa K, Yokoyama Y, Saito M. Surgical stress inhibits the growth of fibroblasts through the elevation of plasma catecholamine and cortisol concentrations. Surgery today. 1997;27(7):627-631.

Sarrazy V, Billet F, Micallef L, Coulomb B, Desmouliere A. Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regen. Sep 2011;19 Suppl 1:s10-15.

Schmiderer C, Lukas B, Ruzicka J, Novak J. DNA-based identification of Calendula officinalis (Asteraceae). Applications in plant sciences. Nov 2015;3(11).

Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, Gottrup F, Gurtner GC, Longaker MT. Human Skin Wounds: A Major and Snowballing Threat to Public Health and the Economy. Wound Repair and Regeneration. 2009;17(6):763–71.

Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen. Jan-Feb 2009;17(1):1-18.

Shahzad MN, Ahmed N. Effectiveness of Aloe Vera Gel Compared with 1% Silver Sulphadiazine Cream as Burn Wound Dressing in Second Degree Burns. The Journal of the Pakistan Medical Association. 2013;63(2):225–30.

Shepherd AA. Nutrition for optimum wound healing. Nursing standard (Royal College of Nursing (Great Britain): 1987). Oct 22-28 2003;18(6):55-58.

Shi HP, Fishel RS, Efron DT, Williams JZ, Fishel MH, Barbul A. Effect of Supplemental Ornithine on Wound Healing. J Surg Res. 2002;106(2):299–302.

Shoab SS, Porter J, Scurr JH, Coleridge-Smith PD. Endothelial Activation Response to Oral Micronised Flavonoid Therapy in Patients with Chronic Venous Disease – a Prospective Study. Eur J Vasc Endovasc Surg. 1999;17(4):313-318.

Sibbald GR, Woo KY. The Biology of Chronic Foot Ulcers in Persons with Diabetes. Diabetes/Metabolism Research and Reviews. 2008;24 (Suppl 1):S25–30.

Sidgwick GP, McGeorge D, Bayat A. A Comprehensive Evidence-Based Review on the Role of Topicals and Dressings in the Management of Skin Scarring. Archives of Dermatological Research. 2015;307(6):461–77.

Simon PE, Romo T, Al Moutran H. Skin Wound Healing. http://emedicine.medscape.com/article/884594-overview. Last updated 1/20/2016. Accessed 12/8/2017.

Simsek G, Sari E, Kilic R, Bayar Muluk N. Topical Application of Arnica and Mucopolysaccharide Polysulfate Attenuates Periorbital Edema and Ecchymosis in Open Rhinoplasty. Plastic and Reconstructive Surgery. 2016;137(3):530e–535e.

Singh AK, Sharma A, Warren J, Madhavan S, Steele K, RajeshKumar NV, Thangapazham RL, et al. Picroliv Accelerates Epithelialization and Angiogenesis in Rat Wounds. Planta Medica. 2007;73 (3):251–56.

Sood A, Granick MS, Tomaselli NL. Wound Dressings and Comparative Effectiveness Data. Advances in wound care. Aug 01 2014;3(8):511-529.

Sorensen LT, Hemmingsen U, Kallehave F, Wille-Jorgensen P, Kjaergaard J, Moller LN, Jorgensen T. Risk factors for tissue and wound complications in gastrointestinal surgery. Ann Surg. Apr 2005;241(4):654-658.

Sorensen LT. Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review. Ann Surg. Jun 2012;255(6):1069-1079.

Sprockett DD, Ammons CG, Tuttle MS. Use of 16S rRNA Sequencing and Quantitative PCR to Correlate Venous Leg Ulcer Bacterial Bioburden Dynamics with Wound Expansion, Antibiotic Therapy, and Healing. Wound Repair and Regeneration. 2015;23(5):765–71.

Steed DL. Debridement. American journal of surgery. May 2004;187(5a):71s-74s.

Stone CA, Wright H, Clarke T, Powell R, Devaraj VS. Healing at Skin Graft Donor Sites Dressed with Chitosan. British Journal of Plastic Surgery. 2000;53(7):601–6.

Tanyuksel M, Araz E, Dundar K, et al. Maggot debridement therapy in the treatment of chronic wounds in a military hospital setup in Turkey. Dermatology (Basel, Switzerland). 2005;210(2):115-118.

Taylor TV, Rimmer S, Day B, Butcher J, Dymock IW. Ascorbic Acid Supplementation in the Treatment of Pressure-Sores. Lancet. 1974;2(7880):544–46.

ter Riet G, Kessels AG, Knipschild PG. Randomized Clinical Trial of Ascorbic Acid in the Treatment of Pressure Ulcers. Journal of Clinical Epidemiology. 1995;48(12):1453–60.

Thangapazham RL, Sharad S, Maheshwari RK. Phytochemicals in Wound Healing. Advances in Wound Care (New Rochelle). 2016;5 5):230–41.

Theilla M, Schwartz B, Cohen J, Shapiro H, Anbar R, Singer P. Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients. American Journal of Critical Care. 2012;21(4):e102–9.

Thom SR, Hampton M, Troiano MA, Mirza Z, Malay DS, Shannon S, Jennato NB, et al. Measurements of CD34+/CD45-Dim Stem Cells Predict Healing of Diabetic Neuropathic Wounds. Diabetes. 2016;65(2):486–97.

Tiganescu A, Tahrani AA, Morgan SA, et al. 11beta-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. The Journal of clinical investigation. Jul 2013;123(7):3051-3060.

Torkaman G. Electrical Stimulation of Wound Healing: A Review of Animal Experimental Evidence. Advances in Wound Care (New Rochelle). 2014;3 2):202–18.

Totonchi A, Guyuron B. A Randomized, Controlled Comparison between Arnica and Steroids in the Management of Postrhinoplasty Ecchymosis and Edema. Plastic and Reconstructive Surgery. 2007;120(1):271–74.

Ubbink DT, Brolmann FE, Go PM, Vermeulen H. Evidence-Based Care of Acute Wounds: A Perspective. Advances in wound care. May 01 2015;4(5):286-294.

Ubbink DT, Santema TB, Stoekenbroek RM. Systemic wound care: a meta-review of cochrane systematic reviews. Surgical technology international. Mar 2014;24:99-111.

Valentine R, Athanasiadis T, Moratti S, Hanton L, Robinson S, Wormald PJ. The Efficacy of a Novel Chitosan Gel on Hemostasis and Wound Healing after Endoscopic Sinus Surgery. American Journal of Rhinology and Allergy. 2010;24(1):70–75.

Vas PR, Ahluwalia R, Manas AB, Manu CA, Kavarthapu V, Edmonds ME. Undiagnosed Severe Sleep Apnoea and Diabetic Foot Ulceration - a Case Series Based Hypothesis: A Hitherto under Emphasized Factor in Failure to Heal. Diabetic Medicine. 2016;33(2):e1–4.

Vasudevan B. Venous leg ulcers: Pathophysiology and Classification. Indian Dermatol Online J. Jul 2014;5(3):366-370.

Vaxman F, Olender S, Lambert A, Nisand G, Aprahamian M, Bruch JF, Didier E, Volkmar P, Grenier JF. Effect of Pantothenic Acid and Ascorbic Acid Supplementation on Human Skin Wound Healing Process. A Double-Blind, Prospective and Randomized Trial. European Surgical Research. 1995;27(3):158–66.

Velnar T, Bailey T, Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. The Journal of international medical research. Sep-Oct 2009;37(5):1528-1542.

Weinheimer-Haus EM, Judex S, Ennis WJ, Koh TJ. Low-Intensity Vibration Improves Angiogenesis and Wound Healing in Diabetic Mice. PloS One. 2014;9(3):e91355.

Wilgus TA, Roy S, McDaniel JC. Neutrophils and Wound Repair: Positive Actions and Negative Reactions. Advances in wound care. Sep 2013;2(7):379-388.

Wilson JA, Clark JJ. Obesity: impediment to postsurgical wound healing. Advances in skin & wound care. Oct 2004;17(8):426-435.

Wolcott R, Sanford N, Gabrilska R, Oates JL, Wilkinson JE, Rumbaugh KP. Microbiota is a primary cause of pathogenesis of chronic wounds. Journal of wound care. Oct 01 2016;25(Sup10):S33-s43.

Wolfe RR, Miller SL, Miller KB. Optimal protein intake in the elderly. Clinical nutrition (Edinburgh, Scotland). Oct 2008;27(5):675-684.

Worster B, Zawora MQ, Hsieh C. Common questions about wound care. American family physician. Jan 15 2015;91(2):86-92.

Yin R, Dai T, Avci P, Jorge AE, de Melo WC, Vecchio D, Huang YY, Gupta A, Hamblin MR. Light Based Anti-Infectives: Ultraviolet C Irradiation, Photodynamic Therapy, Blue Light, and beyond. Current Opinion in Pharmacology. 2013;13(5):731–62.

Young ME. Malnutrition and wound healing. Heart & lung: the journal of critical care. Jan 1988;17(1):60-67.

Young R, Gill JJ. Phage Therapy Redux — What Is to Be Done? Science. 2015;350(6265):1163–64.