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ACP. American College of Phlebology. Practice Guidelines: Superficial Venous Disease. American College of Phlebology;2016.

Alaiti S. Sclerotherapy Treatment & Management. Surgical Therapy. Medscape Last updated 5/29/2017. Accessed 12/12/16.

Almeida JI, Javier JJ, Mackay EG, Bautista C, Cher DJ, Proebstle TM. Two-year follow-up of first human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. Phlebology / Venous Forum of the Royal Society of Medicine. Jul 2015;30(6):397-404.

AMR. Aesculus hippocastanum (Horse chestnut). Monograph. Alternative medicine review: a journal of clinical therapeutic. Sep 2009;14(3):278-283.

AMR. Ruscus aculeatus (butcher's broom). Monograph. Alternative medicine review: a journal of clinical therapeutic. Dec 2001;6(6):608-612.

Andreozzi GM. Sulodexide in the treatment of chronic venous disease. American journal of cardiovascular drugs : drugs, devices, and other interventions. Apr 1 2012;12(2):73-81.

Andreozzi GM, Bignamini AA, Davi G, Palareti G, Matuska J, Holy M, . . . Visona A. Sulodexide for the Prevention of Recurrent Venous Thromboembolism: The Sulodexide in Secondary Prevention of Recurrent Deep Vein Thrombosis (SURVET) Study: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Circulation. Nov 17 2015;132(20):1891-1897.

Aziz Z, Tang WL, Chong NJ, Tho LY. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. Apr 2015;40(2):177-185.

Belcaro G. A Clinical Comparison of Pycnogenol, Antistax, and Stocking in Chronic Venous Insufficiency. The International journal of angiology : official publication of the International College of Angiology, Inc. Dec 2015;24(4):268-274.

Belcaro G, Dugall M, Luzzi R, Hosoi M, Corsi M. Improvements of venous tone with pycnogenol in chronic venous insufficiency: an ex vivo study on venous segments. The International journal of angiology: official publication of the International College of Angiology, Inc. Mar 2014;23(1):47-52.

Bellmunt-Montoya S, Escribano JM, Dilme J, Martinez-Zapata MJ. CHIVA method for the treatment of chronic venous insufficiency. The Cochrane database of systematic reviews. 2015(6):Cd009648.

Bergan JJ, Schmid-Schonbein GW, Smith PD, Nicolaides AN, Boisseau MR, Eklof B. Chronic venous disease. The New England journal of medicine. Aug 3 2006;355(5):488-498.

Bongiovanni CM. WOUNDS: How to Distinguish Arterial, Venous and Other Ulcers. NCVH: New Cardiovascular Horizons; 16th Annual Conference; 2015; New Orleans, Louisiana.

Brittenden J, Cotton SC, Elders A, Ramsay CR, Norrie J, Burr J, . . . Campbell MK. A randomized trial comparing treatments for varicose veins. The New England journal of medicine. Sep 25 2014;371(13):1218-1227.

Calderon Mdel S, Figueroa CS, Arias JS, Sandoval AH, Torre FO. Combined therapy of Ulmo honey (Eucryphia cordifolia) and ascorbic acid to treat venous ulcers. Revista latino-americana de enfermagem. Feb-Apr 2015;23(2):259-266.

CDC. Centers for Disease Control and Prevention. Venous Thromboembolism (Blood Clots). Last updated 3/1/2017. Accessed 7/3/2017.

Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, . . . Corsi M. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clinical and applied thrombosis/hemostasis: official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. Apr 2006;12(2):205-212.

Chandrasekaran SD, Vaithilingam M, Shanker R, Kumar S, Thiyur S, Babu V, . . . Prakash S. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur journal of microbiology. Oct 2015;8(10):e23567.

Chandrika UG, Prasad Kumarab PA. Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. Advances in food and nutrition research. 2015;76:125-157.

Chong NJ, Aziz Z. A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency. Evidence-based complementary and alternative medicine: eCAM. 2013;2013:627182.

Coccheri S, Mannello F. Development and use of sulodexide in vascular diseases: implications for treatment. Drug design, development and therapy. 2014;8:49-65.

Coleridge-Smith P, Lok C, Ramelet AA. Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction. Eur J Vasc Endovasc Surg. Aug 2005;30(2):198-208.

Couzan S, Leizorovicz A, Laporte S, Mismetti P, Pouget JF, Chapelle C, Quere I. A randomized double-blind trial of upward progressive versus degressive compressive stockings in patients with moderate to severe chronic venous insufficiency. J Vasc Surg. Nov 2012;56(5):1344-1350.e1341.

Dabbagh F, Negahdaripour M, Berenjian A, Behfar A, Mohammadi F, Zamani M, . . . Ghasemi Y. Nattokinase: production and application. Applied microbiology and biotechnology. Nov 2014;98(22):9199-9206.

Danielsson G, Eklof B, Grandinetti A, Kistner RL. The influence of obesity on chronic venous disease. Vascular and endovascular surgery. Jul-Aug 2002;36(4):271-276.

de Abreu AM, de Oliveira BG. A study of the Unna Boot compared with the elastic bandage in venous ulcers: a randomized clinical trial. Revista latino-americana de enfermagem. Jul-Aug 2015;23(4):571-577.

De Sanctis MT, Belcaro G, Incandela L, Cesarone MR, Griffin M, Ippolito E, Cacchio M. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology. Oct 2001;52 Suppl 2:S55-59.

Dezotti NRA, Dalio MB, Ribeiro MS, Piccinato CE, Joviliano EE. The clinical importance of air plethysmography in the assessment of chronic venous disease. Jornal Vascular Brasileiro. 2017(AHEAD):0-0.

Di Nisio M, van Es N, Buller HR. Deep vein thrombosis and pulmonary embolism. Lancet. Dec 17 2016;388(10063):3060-3073.

Douketis JD. Merck Manual Professional Version. Chronic Venous Insufficiency and Postphlebitic Syndrome. July 2016b. Accessed 7/3/2017.

Douketis JD. Merck Manual Professional Version. Varicose Veins. July 2016a. Accessed September 1, 2016.

Dudek-Makuch M, Studzińska-Sroka E. Horse chestnut - efficacy and safety in chronic venous insufficiency: an overview. Brazilian Journal of Pharmacognosy. 2015;25:533-541.

Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. Jul 22 2014;130(4):333-346.

Eklof B, Perrin M, Delis KT, Rutherford RB, Gloviczki P. Updated terminology of chronic venous disorders: the VEIN-TERM transatlantic interdisciplinary consensus document. J Vasc Surg. Feb 2009;49(2):498-501.

Falanga V, Margolis D, Alvarez O, Auletta M, Maggiacomo F, Altman M, . . . Hardin-Young J. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group. Arch Dermatol. Mar 1998;134(3):293-300.

FDA. U.S. Food & Drug Administration. FDA approves closure system to permanently treat varicose veins. Last updated 2/20/2015. Accessed October 10, 2016.

Fernandes F, Ramalhosa, E, Pires, P, et al. Vitis vinifera leaves towards bioactivity. Industrial Crops and Products. 2013;43:434-440.

Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: current status and future prospects. Current medicinal chemistry. 2011;18(25):3871-3888.

Fort F. Varicose Veins. Ferri's Clinical Advisor 2017: Elsevier; 2017a.

Fort F. Venous Insufficiency, Chronic. In: Ferri FF, ed. Ferri's Clinical Advisor 2017: Elsevier, Inc.; 2017b.

Franceschi C, Cappelli M, Ermini S, Gianesini S, Mendoza E, Passariello F, Zamboni P. CHIVA: hemodynamic concept, strategy and results. Int Angiol. 2016;35(1):8-30.

Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biological & pharmaceutical bulletin. Oct 1995;18(10):1387-1391.

Gad MA, Saber A, Hokkam EN. Assessment of Causes and Patterns of Recurrent Varicose Veins After Surgery. North American journal of medical sciences. 2012;4(1):45-48.

Gibson K, Ferris B. Cyanoacrylate closure of incompetent great, small and accessory saphenous veins without the use of post-procedure compression: Initial outcomes of a post-market evaluation of the VenaSeal System (the WAVES Study). Vascular. Apr 2017;25(2):149-156.

Ginsberg JS. Peripheral Venous Disease. Goldman-Cecil Medicine: Elsevier; 2016.

Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, . . . Wakefield TW. The care of patients with varicose veins and associated chronic venous diseases: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. Journal of Vascular Surgery. 2011;53(5):2S-48S.

Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation. Sep 25 2007;116(13):1497-1503.

Gohel MS, Davis AH. Excision of Varicose Veins. Current Therapy in Vascular and Endovascular Surgery. Fifth ed. Philadelphia, PA: Elsevier Saunders; 2014:913.

Gohel MS, Davies AH. Pharmacological agents in the treatment of venous disease: an update of the available evidence. Current vascular pharmacology. 2009;7(3):303-308.

Gohel MS, Davies AH. Pharmacological treatment in patients with C4, C5 and C6 venous disease. Phlebology / Venous Forum of the Royal Society of Medicine. Oct 2010;25 Suppl 1:35-41.

Grau M, Bolck B, Bizjak DA, Stabenow CJ, Bloch W. The red-vine-leaf extract AS195 increases nitric oxide synthase-dependent nitric oxide generation and decreases oxidative stress in endothelial and red blood cells. Pharmacol Res Perspect. Feb 2016;4(1):e00213.

Grossmann M, Dobrev D, Himmel HM, Ravens U, Kirch W. Ascorbic acid-induced modulation of venous tone in humans. Hypertension. Mar 2001;37(3):949-954.

Gulati OP. Pycnogenol in chronic venous insufficiency and related venous disorders. Phytotherapy research: PTR. Mar 2014;28(3):348-362.

Hallett J. Merck Manual. Professional Version. Peripheral Artery Disease. 5/2014. Accessed 10/8/2016.

Harding K, Sumner M, Cardinal M. A prospective, multicentre, randomised controlled study of human fibroblast-derived dermal substitute (Dermagraft) in patients with venous leg ulcers. International wound journal. Apr 2013;10(2):132-137.

Hart CE, Loewen-Rodriguez A, Lessem J. Dermagraft: Use in the Treatment of Chronic Wounds. Advances in wound care. Jun 2012;1(3):138-141.

Heinen M, Borm G, van der Vleuten C, Evers A, Oostendorp R, van Achterberg T. The Lively Legs self-management programme increased physical activity and reduced wound days in leg ulcer patients: Results from a randomized controlled trial. International journal of nursing studies. Feb 2012;49(2):151-161.

Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon W, Melton L, Iii. Risk factors for deep vein thrombosis and pulmonary embolism: A population-based case-control study. Archives of internal medicine. 2000;160(6):809-815.

Hettrick H. The Science of Compression Therapy for Chronic Venous Insufficiency Edema. The Journal of the American College of Certified Wound Specialists. 2009;1(1):20-24.

Higdon J. Linus Pauling Institute. Micronutrient Information Center: Vitamin E. Last updated 5/2015. Accessed 5/25/2017.

Hsia CH, Shen MC, Lin JS, Wen YK, Hwang KL, Cham TM, Yang NC. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutrition research (New York, N.Y.). Mar 2009;29(3):190-196.

Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, . . . Kim YB. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Laboratory animal research. Dec 2013;29(4):221-225.

Johns Hopkins Medicine. Health Library. DVT Prevention: Intermittent Pneumatic Compression Devices. dvt_prevention_intermittent_pneumatic_compression_devices_135,328/. Accessed 6/20/2017.

Johnston RV, Hudson MF. Travelers' thrombosis. Aviation, space, and environmental medicine. Feb 2014;85(2):191-194.

Jones RH, Carek PJ. Management of varicose veins. American family physician. Dec 01 2008;78(11):1289-1294.

Jull AB, Arroll B, Parag V, Waters J. Pentoxifylline for treating venous leg ulcers. The Cochrane database of systematic reviews. Dec 12 2012;12:CD001733.

Kalodiki E, Fareed J, Syed D, Geroulakos G, Hoppensteadt D, Lattimer CR. Blood Sampled Directly from Varicose Veins Reveals Activation of Inflammatory Processes. Journal of vascular surgery. Venous and lymphatic disorders. Jan 2015;3(1):119.

Kirsner RS, Marston WA, Snyder RJ, Lee TD, Cargill DI, Slade HB. Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. Lancet. Sep 15 2012;380(9846):977-985.

Kirsner RS, Marston WA, Snyder RJ, Lee TD, Cargill DI, Zhang Y, . . . Slade HB. Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a 6-month follow-up. Wound Repair Regen. Sep-Oct 2013;21(5):682-687.

Kishimoto Y, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A. Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Biochemical and biophysical research communications. Jan 11 2013;430(2):579-584.

Kolluri R. Compression therapy for treatment of venous disease and limb swelling. Current treatment options in cardiovascular medicine. Apr 2011;13(2):169-178.

Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601.

Lattimer CR, Kalodiki E, Geroulakos G, Hoppensteadt D, Fareed J. Are Inflammatory Biomarkers Increased in Varicose Vein Blood? Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. Oct 2016;22(7):656-664.

Lazareth I, Hubert S, Michon-Pasturel U, Priollet P. [Vitamin C deficiency and leg ulcers. A case control study]. Journal des maladies vasculaires. Apr 2007;32(2):96-99.

Ligi D, Mosti G, Croce L, Raffetto JD, Mannello F. Chronic venous disease - Part I: Inflammatory biomarkers in wound healing. Biochimica et biophysica acta. Oct 2016;1862(10):1964-1974.

Lim CS, Davies AH. Graduated compression stockings. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. Jul 08 2014;186(10):E391-398.

MacKay D. Hemorrhoids and varicose veins: a review of treatment options. Alternative medicine review : a journal of clinical therapeutic. Apr 2001;6(2):126-140.

Marola S, Ferrarese A, Solej M, Enrico S, Nano M, Martino V. Management of venous ulcers: State of the art. International journal of surgery (London, England). Sep 2016;33 Suppl 1:S132-134.

Martinez-Zapata MJ, Vernooij RW, Uriona Tuma SM, Stein AT, Moreno RM, Vargas E, . . . Bonfill Cosp X. Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews. 2016;4:Cd003229.

Massee M, Chinn K, Lei J, Lim JJ, Young CS, Koob TJ. Dehydrated human amnion/chorion membrane regulates stem cell activity in vitro. J Biomed Mater Res B Appl Biomater. Oct 2016;104(7):1495-1503.

May JM, Harrison FE. Role of Vitamin C in the Function of the Vascular Endothelium. Antioxidants & redox signaling 2013;19(17):2068-2083.

Mayo Clinic. Patient Care & Health Info page. Diseases and Conditions: Deep vein thrombosis (DVT). Symptoms. 7/3/2014. Accessed 6/29/2017.

McCarty MF, O'Keefe JH, DiNicolantonio JJ. Pentoxifylline for vascular health: a brief review of the literature. Open Heart. 2016;3(1):e000365.

Meesters AA, Pitassi LH, Campos V, Wolkerstorfer A, Dierickx CC. Transcutaneous laser treatment of leg veins. Lasers in medical science. Mar 2014;29(2):481-492.

Morrison N, Gibson K, McEnroe S, Goldman M, King T, Weiss R, . . . Jones A. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. Apr 2015;61(4):985-994.

Morrison N, Gibson K, Vasquez M, Weiss R, Cher D, Madsen M, Jones A. VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. Journal of Vascular Surgery: Venous and Lymphatic Disorders. 2017;5(3):321-330.

Mosti G, Partsch H. High compression pressure over the calf is more effective than graduated compression in enhancing venous pump function. Eur J Vasc Endovasc Surg. Sep 2012;44(3):332-336.

Mosti G, Partsch H. Occupational leg oedema is more reduced by antigraduated than by graduated stockings. Eur J Vasc Endovasc Surg. May 2013;45(5):523-527.

Mowatt-Larssen E, Shortell C. CHIVA. Seminars in vascular surgery. Jun 2010;23(2):118-122.

Muller-Buhl U, Leutgeb R, Engeser P, Achankeng EN, Szecsenyi J, Laux G. Varicose veins are a risk factor for deep venous thrombosis in general practice patients. VASA. Zeitschrift fur Gefasskrankheiten. Sep 2012;41(5):360-365.

Murohara T, Ikeda H, Otsuka Y, Aoki M, Haramaki N, Katoh A, . . . Imaizumi T. Inhibition of platelet adherence to mononuclear cells by alpha-tocopherol: role of P-selectin. Circulation. Jul 13 2004;110(2):141-148.

Nathoo R, Howe N, Cohen G. Skin substitutes: an overview of the key players in wound management. The Journal of clinical and aesthetic dermatology. Oct 2014;7(10):44-48.

NHS. National Health Institute. Deep vein thrombosis. 4/27/2016a. Accessed 6/29/2017.

NHS. National Health Services. Causes of deep vein thrombosis (DVT). 4/27/2016b. Accessed 6/29/2017.

NICE. National Institute for Health and Care Excellence. Varicose veins in the legs: The diagnosis and management of varicose veins. U.K.: National Institute for Health and Care Excellence; 2013.

Nicholas MN, Yeung J. Current Status and Future of Skin Substitutes for Chronic Wound Healing. Journal of cutaneous medicine and surgery. 2017;21(1):23-30.

Nicholls SC. Sequelae of untreated venous insufficiency. Seminars in interventional radiology. Sep 2005;22(3):162-168.

NIH. National Heart, Lung, and Blood Institute. How Are Varicose Veins Treated? Last updated 2/13/2014c. Accessed 7/3/2017.

NIH. National Heart, Lung, and Blood Institute. What Are the Signs and Symptoms of Varicose Veins? Last updated 2/13/2014b. Accessed 7/3/2017.

NIH. National Heart, Lung, and Blood Institute. Who Is at Risk for Varicose Veins? Last updated 1/29/2016. Accessed September 22, 2016.

NIH. National Institutes of Health. National Heart, Lung, and Blood Institute. What Is Pulmonary Embolism? Last updated 7/1/2011. Accessed 6/29/2017.

NIH. National Heart, Lung, and Blood Institute. What are varicose veins? Last updated 2/13/2014a. Accessed September 1, 2016.

Omar AA, Mavor AI, Jones AM, Homer-Vanniasinkam S. Treatment of venous leg ulcers with Dermagraft. Eur J Vasc Endovasc Surg. Jun 2004;27(6):666-672.

Parsa H, Zangivand AA, Hajimaghsoudi L. The effect of pentoxifylline on chronic venous ulcers. Wounds : a compendium of clinical research and practice. Jul 2012;24(7):190-194.

Patel K. Medscape. Drugs & Diseases page. Deep Vein Thrombosis. Last updated 3/30/2016. Accessed 6/29/2017.

Petruzzellis V, Troccoli T, Candiani C, Guarisco R, Lospalluti M, Belcaro G, Dugall M. Oxerutins (Venoruton): efficacy in chronic venous insufficiency--a double-blind, randomized, controlled study. Angiology. May-Jun 2002;53(3):257-263.

Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. The Cochrane database of systematic reviews. Nov 14 2012;11:CD003230.

Pointel JP, Boccalon H, Cloarec M, Ledevehat C, Joubert M. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology. Jan 1987;38(1 Pt 1):46-50.

Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components. The Journal of bone and joint surgery. American volume. Jul 2001;83-a(7):1057-1061.

Poredos P, Spirkoska A, Rucigaj T, Fareed J, Jezovnik MK. Do blood constituents in varicose veins differ from the systemic blood constituents? Eur J Vasc Endovasc Surg. Aug 2015;50(2):250-256.

Proebstle TM, Alm J, Dimitri S, Rasmussen L, Whiteley M, Lawson J, . . . Davies A. The European multicenter cohort study on cyanoacrylate embolization of refluxing great saphenous veins. Journal of vascular surgery. Venous and lymphatic disorders. Jan 2015;3(1):2-7.

Pullen L. Sulodexide Does Not Prevent Kidney Failure. 10/27/2011. Accessed 12/5/16.

Rabe E, Guex JJ, Morrison N, Ramelet AA, Schuller-Petrovic S, Scuderi A, . . . Pannier F. Treatment of chronic venous disease with flavonoids: recommendations for treatment and further studies. Phlebology / Venous Forum of the Royal Society of Medicine. Sep 2013;28(6):308-319.

Rabe E, Stucker M, Esperester A, Schafer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. Apr 2011;41(4):540-547.

Rasmussen LH, Lawaetz M, Bjoern L, Vennits B, Blemings A, Eklof B. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. The British journal of surgery. Aug 2011;98(8):1079-1087.

Rottenberger Z, Komorowicz E, Szabo L, Bota A, Varga Z, Machovich R, . . . Kolev K. Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. Journal of thrombosis and haemostasis: JTH. Mar 2013;11(3):529-538.

Scallan J, Huxley VH, J. KR. Capillary Fluid Exchange: Regulation, Functions, and Pathology. Chapter 4: Pathophysiology of Edema Formation. San Rafael (CA): Morgan & Claypool Life Sciences; 2010.

Scherger J. First Consult. Varicose Veins. Last updated 6/18/2012. Accessed 9/1/2016.

Serena TE, Carter MJ, Le LT, Sabo MJ, DiMarco DT, EpiFix VLUSG. A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment of venous leg ulcers. Wound Repair Regen. Nov-Dec 2014;22(6):688-693.

Shadid N, Ceulen R, Nelemans P, Dirksen C, Veraart J, Schurink GW, . . . Sommer A. Randomized clinical trial of ultrasound-guided foam sclerotherapy versus surgery for the incompetent great saphenous vein. The British journal of surgery. Aug 2012;99(8):1062-1070.

Shaydakov ME, Comerota AJ, Lurie F. Primary venous insufficiency increases risk of deep vein thrombosis. Journal of vascular surgery. Venous and lymphatic disorders. Apr 2016;4(2):161-166.

Sherlock O, Dolan A, Athman R, Power A, Gethin G, Cowman S, Humphreys H. Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC complementary and alternative medicine. 2010;10(1):47.

Shu X, Keller TCt, Begandt D, Butcher JT, Biwer L, Keller AS, . . . Isakson BE. Endothelial nitric oxide synthase in the microcirculation. Cellular and molecular life sciences : CMLS. Dec 2015;72(23):4561-4575.

St. George J. Evaluation and treatment of lower extremity superficial venous insufficiency. Northeast Florida Medicine. 2012;63(2):23-28.

Stucker M, Debus ES, Hoffmann J, Junger M, Kroger K, Mumme A, . . . Rabe E. Consensus statement on the symptom-based treatment of chronic venous diseases. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. Jun 2016;14(6):575-583.

Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta haematologica. 1990;84(3):139-143.

Szymanski M, Mlynarek D, Szymanski A, Matlawska I. Simultaneous Determination of Diosmin and Hesperidin in Pharmaceuticals by RPLC using Ionic Liquids as Mobile Phase Modifiers. Iranian journal of pharmaceutical research: IJPR. Winter 2016;15(1):141-148.

Threapleton DE, Greenwood DC, Evans CE, Cleghorn CL, Nykjaer C, Woodhead C, . . . Burley VJ. Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis. BMJ (Clinical research ed.). Dec 19 2013;347:f6879.

Toledo RR, Santos ME, Schnaider TB. Effect of Pycnogenol on the Healing of Venous Ulcers. Annals of vascular surgery. 2017;38:212-219.

UWHealth. University of Wisconsin Hospitals and Clinics Authority. Health Facts for you: Care of Your Unna Boot Dressing. Copyright 2/2015. Accessed 5/16/2017.

Wadworth AN, Faulds D. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs. Dec 1992;44(6):1013-1032.

Wali MA, Eid RA. Changes of elastic and collagen fibers in varicose veins. Int Angiol. Dec 2002;21(4):337-343.

Wang H, Chen Q, Fei Z, Zheng E, Yang Z, Huang X. Hemodynamic classification and CHIVA treatment of varicose veins in lower extremities (VVLE). International Journal of Clinical and Experimental Medicine. 2016;9(2):2465-2471.

Weiss R. Venous Insufficiency. Background. Last updated 5/26/2016. Accessed 11/08/2016.

Wittens C, Davies AH, Baekgaard N, Broholm R, Cavezzi A, Chastanet S, . . . European Society for Vascular S. Editor's Choice - Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. Jun 2015;49(6):678-737.

Wu B, Lu J, Yang M, Xu T. Sulodexide for treating venous leg ulcers. The Cochrane database of systematic reviews. Jun 02 2016(6):CD010694.

Xu J, Du M, Yang X, Chen Q, Chen H, Lin DH. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta haematologica. 2014;132(2):247-253.

Yildiz C, Conkbayir, C, Huseynov, E. The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfucntion. Phlebology / Venous Forum of the Royal Society of Medicine. 2016;0(0):1-6.

Yu Z, Su P. Effect of beta-aescin extract from Chinese buckeye seed on chronic venous insufficiency. Die Pharmazie. Jun 2013;68(6):428-430.

Zaulyanov L, Kirsner RS. A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. Clinical interventions in aging. 2007;2(1):93-98.

Zhan HT, Bush RL. A review of the current management and treatment options for superficial venous insufficiency. World journal of surgery. Oct 2014;38(10):2580-2588.

Zmudzinski M, Malo P, Hall C, Hayashi A. CHIVA–A prospective study of a vein sparing technique for the management of varicose vein disease. The American Journal of Surgery. 2017.