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Sjögren's Syndrome


Baudouin C, Pisella PJ, et al. [Current treatments of xerophthalmia in Sjögren's syndrome] Rev Med Interne. 2004 May;25(5):376–382. Review. French.

Baudouin C. The pathology of dry eye. Surv Ophthalmol. 2001 Mar;45 Suppl 2:S211–S20. Review.

Bombardieri M, Barone F, et al. Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. Arthritis Res Ther. 2004;6(5):R447–R456.

Brauch JE, Buchweitz M, Schweiggert RM, Carle R. Detailed analyses of fresh and dried maqui (Aristotelia chilensis (Mol.) Stuntz) berries and juice. Food chemistry.Jan 1 2016;190:308-316.

Brito-Zeron P, Ramos Casals M, et al. Circulating monoclonal immunoglobulins in Sjogren syndrome: prevalence and clinical significance in 237 patients. Medicine (Baltimore). 2005 Mar;84(2):90–97.

Calonge M, Enriquez-de-Salamanca A, Diebold Y, Gonzalez-Garcia MJ, Reinoso R, Herreras JM, Corell A. Dry eye disease as an inflammatory disorder. Ocular immunology and inflammation.Aug 2010;18(4):244-253.

Carsons S. The New Sjögren's Syndrome Handbook 1998. New York: Oxford University Press.

Chen Y, Chauhan SK, Lee HS, Saban DR, Dana R. Chronic dry eye disease is principally mediated by effector memory Th17 cells. Mucosal immunology.Jan 2014;7(1):38-45.

Coursey TG, de Paiva CS. Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy. Clinical Ophthalmology (Auckland, N.Z.).08/04 2014;8:1447-1458.

Derk CT, Vivino FB. A primary care approach to Sjögren's syndrome: helping patients cope with sicca symptoms, extraglandular manifestations. Postgrad Med. 2004 Sep;116(3):49–54,59,65. Review.

Fife RS, Chase WF, et al. Cevimeline for the treatment of xerostomia in patients with Sjogren syndrome: a randomized trial. Arch Intern Med. 2002 Jun 10;162(11):1293–1300.

Feng Z, Xu J, He G, Cao M, Duan L, Chen L, Wu Z. The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis. Evidence-based complementary and alternative medicine: eCAM. 2016;2016:9852793.

Gerli R, Bertotto A, et al. Anti-CD3 and anti-CD2-induced Tcell activation in primary Sjögren's syndrome. Clin Exp Rheumatol. 1989 Sep-Oct;7(Suppl. 3):S129-S134.

Glaser R, Rabin B, et al. Stress-induced immunomodulation: implications for infectious diseases. JAMA. 1999 Jun 23–30;281(24):2268–2270.

Hadden JW, Hadden EM. Therapy of secondary T-cell immunodeficiencies with biological substances and drugs. Med Oncol Tumor Pharmacother. 1989;6(1):11.

Harbige LS. Dietary n-6 and n-3 fatty acids in immunity and autoimmune disease. Proc Nutr Soc. 1998 Nov;57(4):555–562.

Hayashi Y, Arakaki R, et al. Apoptosis and estrogen deficiency in primary Sjogren syndrome. Curr Opin Rheumatol . 2004 Sep;16(5):522–526. Review. Erratum in: Curr Opin Rheumatol. 2004 Nov;16(6):753.

He DY, Dai SM. Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine. Frontiers in pharmacology. 2011;2:10.

Hitoe S, Tanaka J, Shimoda H. MaquiBright standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clinical pilot trial. Panminerva medica.Sep 2014;56(3 Suppl 1):1-6.

Horrobin DF. Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis. Scand J Rheumatol. Suppl. 1986;61:242–245.

Horrobin DF. Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjögren's syndrome. Med Hypotheses. 1984 July;14(3):233–247.

Horrobin DF. Loss of delta-6-desaturase activity as a key factor in aging. Med Hypotheses. 1981 Sep;7(9):1211–1220.

Hsu S, Dickinson DP, Qin H, et al. Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells. J Pharmacol Exp Ther. 2005 Nov;315(2):805-11.

Ishimaru N, Saegusa K, et al. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosis. Am J Pathol. 1999 Jul;155(1):173–181.

Klimberg VS, Salloum RM, et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg. 1990 Aug;125(8):1040–1045.

Kouttab NM , Prada M, et al. Thymomodulin: biological properties and clinical applications. Med Oncol Tumor Pharmacother. 1989;6(1):5.

Kujawa A, Rozycki R. [Immunological phenomenons in the pathology of the tear film. Is cyclosporine the turn point in the Sjögren's syndrome treatment? Preliminary report] Klin Oczna. 2004;106(3 Suppl):489–491. Polish.

Lazarus MN, Isenberg DA. Development of additional autoimmune diseases in a population of patients with primary Sjogren's syndrome. Ann Rheum Dis. 2005 Jul;64(7):1062-4.

Li H, Sun X, Zhang J, et al. Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression. International immunopharmacology. Jan 2016;30:27-35.

Lynge Pedersen AM, Bardow A, et al. Salivary changes and dental caries as potential oral markers of autoimmune salivary gland dysfunction in primary Sjögren's syndrome. BMC Clin Pathol. 2005 Mar 1;5(1):4

Mahoney EJ, Spiegel JH. Sjögren's disease. Otolaryngol Clin North Am. 2003 Aug;36(4):733–745. Review.

Mariette X. Current and potential treatments for primary Sjögren's syndrome. Joint Bone Spine. 2002 Jun;69(4):363–366. Review.

Nakamura S, Tanaka J, Imada T, Shimoda H, Tsubota K. Delphinidin 3, 5-O-diglucoside, a constituent of the maqui berry (Aristotelia chilensis) anthocyanin, restores tear secretion in a rat dry eye model. Journal of Functional Foods.2014;10:346-354.

Nusair S, Rubinow A. The use of oral pilocarpine in xerostomia and Sjögren's syndrome. Semin Arthritis Rheum. 1999 Jun;28(6):360–367.

Oxholm P, Asmussen K, et al. Essential fatty acid status in cell membranes and plasma of patients with primary Sjögren's syndrome. Correlations to clinical and immunologic variables using a new model for classification and assessment of disease manifestations. Prostaglandins Leukot Essent Fatty Acids. 1998 Oct;59(4):239–245.

Oxholm P, Manthorpe R, et al. Patients with primary Sjögren's syndrome treated for two months with evening primrose oil. Scand J Rheumatol. 1986;15(2):103–108.

Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005 Apr;98(4):1154–1162.

Romanucci V, D’Alonzo, Guaranga A, et al. Bioactive Compounds of Aristotelia chilensis Stuntz and their Pharmacological Effects. Current pharmaceutical biotechnology. 2016;17(6):513-523.

Rousso E, Noel E, et al. [Recurrent facial palsy, primary Gougerot-Sjögren's syndrome and vitamin B12 deficiency] Presse Med. 2005 Jan 29;34(2 Pt 1):107–108. French.

Schreckinger ME, Lotton J, Lila MA, de Mejia EG. Berries from South America: a comprehensive review on chemistry, health potential, and commercialization. Journal of medicinal food.Apr 2010;13(2):233-246.

Ship JA, Fox PC, et al. Treatment of primary Sjögren's syndrome with low-dose natural human interferon-alpha administered by the oral mucosal route: a phase II clinical trial. IFN Protocol Study Group. J Interferon Cytokine Res. 1999 Aug;19(8):943–951.

Sjögren's Syndrome Foundation. Available at: www.Sjögren' Accessed October 10, 2005.

Stevenson HA, Jones ME, et al. UK patients with primary Sjögren's syndrome are at increased risk from clinical depression. Gerodontology. 2004 Sep;21(3):141–145.

Talal N. Overview of Sjögren's syndrome. J Dent Res. 1987 Feb;66(Spec No):672–674.

Tanaka J, Kadekaru T, Ogawa K, Hitoe S, Shimoda H, Hara H. Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Food chemistry. Aug 15 2013;139(1-4):129-137.

Tishler M, Paran D, et al. Allergic disorders in primary Sjögren's syndrome. Scand J Rheumatol. 1998;27(3):166–169.

Tsubota K, Monden Y, et al. New treatment of dry eye: the effect of calcium ointment through eyelid skin delivery. Br J Ophthalmol. 1999 Jul;83(7):767–770.

Valtysdottir ST , Wide L, et al. Low serum dehydroepiandrosterone sulfate in women with primary Sjögren's syndrome as an isolated sign of impaired HPA axis function. J Rheumatol. 2001 Jun;28(6):1259–1265.

Venables PJ. Sjögren's syndrome. Best Pract Res Clin Rheumatol. 2004 Jun;18(3):313–329. Review.

Watson R, Schönlau F. Nutraceutical and antioxidant effects of a delphinidin-rich maqui berry extract Delphinol®: a review. Minerva cardioangiologica.2015;63(2 Suppl 1):1-12.

Wei Y, Asbell PA. The Core Mechanism of Dry Eye Disease (DED) Is Inflammation. Eye & contact lens.2014;40(4):248-256.

Wilson JL. Thymus extracts: an international literature review of clinical studies 1999. Available at Accessed October 10, 2005.

Wu AJ. The oral component of Sjögren's syndrome: pass the scalpel and check the water. Curr Rheumatol Rep. 2003 Aug;5(4):304–310.

Wu G, Wu N, Li T, Lu W, Yu G. Total glucosides of peony ameliorates Sjogren's syndrome by affecting Th1/Th2 cytokine balance. Experimental and therapeutic medicine. Mar 2016;11(3):1135-1141.

Wu GL, Pu XH, Yu GY, Li TY. Effects of total glucosides of peony on AQP-5 and its mRNA expression in submandibular glands of NOD mice with Sjogren's syndrome. European review for medical and pharmacological sciences. Jan 2015;19(1):173-178.

Yamada S, Mori K, et al. Interferon alfa treatment for Sjögren's syndrome associated neuropathy. J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):576–578.

Zhang HF, Hou P, Xiao WG. [Clinical observation on effect of total glucosides of paeony in treating patients with non-systemic involved Sjogren syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban. Jul 2007;27(7):596-598.

Zhang NZ, Shi QS, et al. [Epidemiological studies on primary Sjögren's syndrome] Zhonghua Nei Ke Za Zhi. 1993 Aug;32(8):522–524. Chinese.

Zhang W, Dai SM. Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. International immunopharmacology.Sep 2012;14(1):27-31.

Zhou Y, Jin L, Kong F, et al. Clinical and immunological consequences of total glucosides of paeony treatment in Sjogren's syndrome: A randomized controlled pilot trial. International immunopharmacology. Aug 9 2016;39:314-319.