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Mitochondrial Energy Optimizer with BioPQQ®

120 capsules
Item# 01868

Retail Price: $72.00

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Description

  • Mitochondrial Energy Optimizer with BioPQQ®
  • 120 capsules
  • Item Catalog Number: 01868

Known as "cellular dynamos," healthy mitochondria produce the energy that powers cells. As people age, however, mitochondria both lose function and decrease in number. Life Extension's unique Mitochondrial Energy Optimizer with BioPQQ® was formulated to enhance mitochondrial function, protect delicate cellular structures, power-charge metabolic processes, and aid in the creation of new mitochondria.

Benefits at a Glance:

  • Supports healthy mitochondrial function and cellular energy output
  • Helps generate new mitochondria
  • Protects cellular structures against glycation reactions and free radicals
  • Inhibits inflammatory factors
  • Aids in cellular metabolism of glucose

Comprehensive Mitochondrial Support

As the importance of mitochondria for healthy cells comes into focus, researchers have identified a number of compounds that can help mitochondria function more efficiently and even help generate new mitochondria. These compounds have been combined into the innovative, multi-ingredient formula, Mitochondrial Energy Optimizer with BioPQQ®.

The following unique ingredients in Mitochondrial Energy Optimizer with BioPQQ® have all been shown to benefit mitochondria:

  • PQQ. This novel micronutrient represents a breakthrough in mitochondrial support. PQQ has been shown to actually trigger the creation of new mitochondria1 and protect the delicate structures of existing mitochondria.2-6
  • Carnosine. Carnosine has been shown to protect cellular structures against advanced glycation end-products (AGEs). These damaging compounds are formed when proteins or lipids are cross-linked with sugars in a process known as glycation. Glycation is linked to a host of negative age-related events in the neurologic, vascular, renal and ocular areas.7-17 Carnosine is a powerful anti-glycating agent, and protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.18-24
  • Luteolin. Luteolin is a plant-derived flavonoid that has been shown to inhibit inflammatory factors, which have been linked to virtually every undesirable consequence of aging. Luteolin works by suppressing pro-inflammatory cytokines, including interleukin-1 and tumor necrosis factor-alpha.25-34
  • Benfotiamine. Benfotiamine operates along multiple pathways to protect cellular integrity. It has been shown in studies to protect cells against the damaging effects of excess glucose by increasing glucose metabolism and protecting against the formation of AGEs.35-43 Studies have shown that the ideal fasting glucose levels are between 70–85 mg/dL. Many aging people, however, have fasting glucose levels above 90 mg/dL. Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels already within normal range. Additionally, benfotiamine has been shown to act as an antioxidant that supports healthy DNA function.44
  • Pyridoxal 5'-Phosphate. This active form of vitamin B6 has been shown to protect against glycation reactions caused by both lipids and proteins.45-49
  • R-lipoic acid. R-lipoic acid protects mitochondria against free radicals while promoting youthful mitochondrial function. The R-lipoic form is more potent than the other form of lipoic acid on the supplement market.50-57
  • Taurine. This amino acid supports neurite growth58 and powerfully protects the mitochondria59 from oxidative damage to enhance energy production within cells.58,60,61  Taurine is prevalent throughout the body62 and found in especially high amounts in the metabolically active cells that require high mitochondrial energy production (brain,62 nerve, eye cells,63 heart,64 and skeletal muscle65).

Purchasing each of these potent ingredients individually would be prohibitively expensive. But Mitochondrial Energy Optimizer with BioPQQ® combines them into one cost-effective formulation that helps support healthy mitochondria.

References

  1. J Biol Chem. 2010. Jan 1;285:142-52.
  2. Alt Med Rev. 2009; 14(3):268-77.
  3. Entrez Gene: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [ Homo sapiens ] GeneID: 10891.
  4. Entrez Gene: CREBBP CREB binding protein [ Homo sapiens ] GeneID: 1387.
  5. Exp Gerontol. 2015 Jun;66:1-9.
  6. Eur Spine J. 2015 Aug;24(8):1702-10.
  7. Diabetologia. 2002 Oct;45(10):1457-62.
  8. Pathol Biol (Paris). 2003 Dec;51(10):543-9.
  9. Brain Res Rev. 2003 Mar;41(2-3):306-23.
  10. Arthritis Rheum. 2004 Apr;50(4):1207-15.
  11. Med Hypotheses. 2004;62(2):275-9.
  12. Can J Physiol Pharmacol. 2000 Oct;78(10):848-55.
  13. Ann N Y Acad Sci. 2001 Apr;928:48-53.
  14. Arthritis Rheum. 2002 Jan;46(1):114-23.
  15. J InvestDermatol. 2002 Aug;119(2):489-98.
  16. Kurume Med J.2002;49(1-2):7-13.
  17. Curr Pharm Des. 2008;14(10):946-52.
  18. J Alzheimers Dis. 2007 May;11(2):229-40.
  19. Curr Clin Pharmacol.2011 Nov;6(4):236-59.
  20. Ann N Y Acad Sci. 2006 May;1067:369-74.
  21. Eur J Pharmacol. 2011 Jan 10;650(1):184-94.
  22. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
  23. Neurobiol Aging. 2014 Jun;35(6):1469-72.
  24. Atherosclerosis. 2014 Feb;232(2):403-9.
  25. Life Sci. 2007 Nov 30;81(23-24):1602-14.
  26. J Nutr. 2006 Jun;136(6):1517-21.
  27. J Neuroinflammation. 2008 Sep 25;5:41.
  28. Immunology. 2005 Jul;115(3):375-87.
  29. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.
  30. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.
  31. Neurosci Lett. 2008 Dec 26;448(2):175-9.
  32. Biochimie. 2011 Mar;93(3):506-12.
  33. J Pharmacol Exp Ther. 2011 Sep;338(3):1013-22.
  34. Int J Neurosci. 2011 Jun;121(6):329-36.
  35. Nat Med. 2003 Mar;9(3):294-9.
  36. J Am Soc Nephrol. 2011 May;22(5):914-26.
  37. Pharmacol Res. 2010 Jun;61(6):482-8.
  38. Diabetes Care. 2006 Sep;29(9):2064-71.
  39. Circ Heart Fail. 2010 Mar;3(2):294-305.
  40. Acta Diabetol. 2001;38(3):135-8.
  41. J Pak Med Assoc.2012 Oct;62(10):1033-8.
  42. Acta Diabetol. 2012 Dec;49 Suppl 1:S141-51.
  43. Genes Nutr. 2012 Jul;7(3):459-69.
  44. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7.
  45. Biochem Biophys Acta. 2001 Feb.14;1535(2):110-9.
  46. J Lipid Res. 2006 May; 47(5): 964-74.
  47. J Am Soc Nephrol. 2005 Jan;16(1):144-50.
  48. Life Sci. 1988;43(21):1725-31.
  49. Amino Acids. 2012 Apr;42(4):1163-70. 
  50. FASEB J. 1999 Feb;13(2):411-8.
  51. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
  52. FASEB J. 2001 Mar;15(3):700-6.
  53. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35.
  54. Redox Rep. 2005;10(1):52-60.
  55. Altern Med Rev. 2007 Dec;12(4):343-51.
  56. Aging Cell. 2013 Dec;12(6):1021-31.
  57. J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302.
  58. Amino Acids. 2015 Apr;47(4):735-44.
  59. Mol Vis. 2012; 18: 2673–2686.
  60. Neurosci Lett. 2015 Mar 17;590:52-7.
  61. Adv Exp Med Biol. 2015;803:397-405.
  62. Adv Exp Med Biol. 2015;803:409-13.
  63. Prog Retin Eye Res. 2014 Jul;41:44-63.
  64. Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H232-9.
  65. J Transl Med. 2015 Jul 25;13:243.

SUPPLEMENT FACTS

Supplement Facts

Serving Size 4 capsules

Servings Per Container 30

Amount Per Serving

Vitamin B6 (as pyridoxal 5’-phosphate)

100 mg

Sodium

18 mg

Carnosine

1000 mg

L-Taurine

800 mg

Benfotiamine

150 mg

R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate)

150 mg

BioPQQ® Pyrroloquinoline quinone disodium salt

10 mg

Luteolin [from orange extract (fruit)]

8 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, candelilla wax, beeswax, stearic acid, silica, corn starch, acacia gum, calcium silicate.

Non-GMO

BioPQQ® is a registered trademark of MGC (Japan).
Bio-Enhanced® is a registered trademark of Geronova Research, Inc.

Dosage and Use
  • Take two (2) capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.
  • This product can be taken with or without food.
Warnings

REVIEWS

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer.

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