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Endothelial Defense™ with Pomegranate Complete and CORDIART™

Support Your Cardiovascular Health

60 softgels
Item# 01997

Retail Price: $68.00

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  • Endothelial Defense™ with Pomegranate Complete and CORDIART™
  • 60 softgels
  • Item Catalog Number: 01997

Blood vessels are lined with a delicate layer of cells known as the endothelium. This endothelial layer is responsible for regulating the health and function of arteries and veins. As you age, protecting the endothelium is critical for maintaining cardiovascular and vascular health. Life Extension’s unique Endothelial Defensewith Pomegranate Complete and CORDIART™ combines three powerful ingredients that have been shown to support a healthy vascular endothelium.

Benefits at a Glance:

  • Supports healthy endothelial function
  • Pomegranate extracts encourage youthful lipid and glucose metabolism and help inhibit inflammatory factors
  • An orally available form of superoxide dismutase (SOD) protects against nitric oxide degradation, which supports healthy arterial function
  • Sweet orange peel extract helps activate endothelial nitric oxide production

Triple-Action Protection for Endothelial Health

This comprehensive formula is made up of the following ingredients shown to support healthy endothelial function:1-7

  • Pomegranate Complete contains polyphenol extracts from every part of the pomegranate, including the seed, flower, and fruit. These extracts have been shown to promote youthful lipid and glucose metabolism1 while inhibiting inflammatory factors2 to support healthy blood flow.3,4
  • GliSODin® is an orally active form of superoxide dismutase (SOD) that has been shown to support healthy arterial function and structure. It boosts levels of the antioxidants SOD and catalase.5-7 Production of SOD declines with age, however, resulting in increased degradation of nitric oxide in the endothelium.  
  • The addition of CORDIART™ (extract from sweet orange peels) to pomegranate provides another vascular benefit by activating endothelial production of nitric oxide, which signals the smooth muscles to relax, inducing vasodilation to support healthy circulation. In clinical research, 500 mg of CORDIART™ alone produced an 18% improvement in flow mediated dilation, a direct marker of endothelial function. CORDIART™ also inhibited the pro-inflammatory factors C-reactive protein and serum amyloid A that interrupt healthy nitric oxide production.8

If you’re ready to give your cardiovascular health a boost, add Endothelial Defense™ with Pomegranate Complete and CORDIART™ to your daily regimen and put the power of pomegranate to work for you.

  1. Nutr Res. 2014 Oct;34(10):862-7.
  2. Altern Med Rev. 2008 Jun;13(2):128-44.
  3. Clin Nutr. 2004 Jun;23(3):423-33.
  4. Am J Cardiol. 2005 Sep 15;96(6):810-4.
  5. Phytother Res. 2004 Dec;18(12):957-62.
  6. Intensive Care Med. 2007 Apr;33(4):694-702.
  7. Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.
  8. http://www.cordiart.com/ Accessed June 9, 2016.


Supplement Facts

Serving Size 2 softgels

Servings Per Container 30

Amount Per Serving

Superoxide dismutase/gliadin complex (GliSODin®) [SOD (superoxide dismutase) enzyme activity = 500 IU]

500 mg

CORDIART™ flavonoid glycoside [from immature sweet orange (peel)] [std. to 90% rutinoside]

500 mg

POMELLA® pomegranate extract (fruit) [std. to 30% punicalagins]

400 mg

Proprietary pomegranate blend (flower extract and seed oil) [std. to 22% punicic acid]

137.5 mg

Pomegranate 5:1 extract (fruit)

100 mg

Other ingredients: extra virgin olive oil, gelatin, maltodextrin, glycerin, purified water, sunflower lecithin, carob color, beeswax.

Contains wheat.


POMELLA® Extract is covered under U.S. Patent 7,638,640 and POMELLA® is a registered trademark of Verdure Sciences, Inc.
Isocell SA, France is the owner of US Patents Nos. 6,045,809 and 6,426,068B1 and trademark of GliSODin®.
CORDIART™ is a trademark of BioActor B.V.

Dosage and Use
  • Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner.

Do not take this product if you are allergic to wheat or gluten.



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