Youthful skin reflects the inner workings of growth factors that drive tissue function and regeneration in response to both internal and external factors.¹ The decreased concentrations of four key growth factors as we grow older inhibit the skin matrix and lead to the tell-tale signs of normal aging. Replenishing these growth factors restores the skin's natural rejuvenation process.² Research shows that when topically applied as a serum, these growth factors support the appearance of firmer, younger skin.

• Epidermal growth factor (EGF): sh-Oligopeptide-1 supports the proliferation of epithelial cells to promote skin health and activates hyaluronan synthase 2—an enzyme involved in manufacturing hyaluronic acid that restores skin hydration.³
• Insulin-like growth factor-1 (IGF-1): sh-Oligopeptide-2 supports the proliferation of fibroblasts that synthesize skin matrix components including collagen, elastin, and hyaluronic acid.⁴
• Vascular endothelial growth factor (VEGF): sh-Polypeptide-9 supports the formation of new blood vessels (angiogenesis) and vascular permeability to allow a greater delivery of oxygen and nutrients into the extracellular matrix to facilitate function.⁵
• Fibroblast growth factor (FGF): sh-Polypeptide-1 and sh-Polypeptide-11 support the production of collagen and elastin that gives skin its tensile strength and elasticity.⁶ It also supports skin matrix rejuvenation.