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HLA-DQ Genetic Test for Celiac Disease Susceptibility


Item# LC100060

Your Price:
$189.00 Save 25%

HLA-DQ Genetic Test for Celiac Disease Susceptibility

Are you at risk for a dangerous reaction to gluten?


Item# LC100060

Retail Price: $252.00

Your Price: $189.00 Save 25%

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Description

  • HLA-DQ Genetic Test for Celiac Disease Susceptibility
  • Item Catalog Number: LC100060

This test provides complete genotyping of your DQA and DQB HLA protein chains and contains the following information:

  • DQ2 genotyping (DQA1*0501, DQA1*0505 and DQB1*0201/*0202)
  • DQ8 genotyping (DQB1*0302 and DQA1*03)
  • ½ DQ2
  • Homozygosity for DQB1*02

Sample Report

Celiac disease (CD) is caused by an immune response to gluten (a protein found in cereal grains) in genetically predisposed people. Although it is estimated that 1 out of 100 people are affected, fewer than 5% of those affected are actually diagnosed.1,2 Failure to identify CD due to its variable non-specific symptoms and varying age of onset may result in in life long complications as well as secondary autoimmune disorders.1,3

This genetic predisposition to develop CD is linked to human leukocyte antigen (HLA) class II alleles, in the HLA-DQ region of chromosome 6. The chart below gives the CD risk associated with the allele variants identified by this test.

The HLA-DQ2 allele has been found in about 95% of celiac cases, and HLA-DQ8 has been identified in nearly all 5% of the remaining cases. These HLA alleles are also found in 48-65% of first-degree relatives of people with CD and in up to 73% of people with insulin-dependent diabetes (type I diabetes) increasing these individual's risk of developing CD.4 Other high-risk groups who are likely to have these HLA alleles include people with autoimmune thyroiditis, rheumatoid arthritis, and IgA deficiency; as well as individuals with symptoms of unexplained iron deficiency anemia or premature-onset osteoporosis.4,5 Sometimes celiac disease is triggered, or becomes active for the first time, after surgery, viral infection or severe emotional stress.

Estimated Celiac Risk from Associated HLA Genotypes6,7

HLA DQ2/DQ8 GENOTYPE

RISK

 DQ2 + DQ8

 1:7 (14.3%)

 DQ2 + DQ2 OR DQ2 Homozygous DQB1*02

 1:10 (10%)

 DQ8 + DQ8

 1:12 (8.4%)

 DQ8 + DQB1*02

 1:24 (4.2%)

 Homozygous DQB1*02

 1:26 (3.8%)

 DQ2 alone

 1:35 (2.9%)

 DQ8 alone

 1:89 (1.1%)

 General Population risk (genotype unknown)

 1:100 (1%)

 ½ DQ2:DQB1*02

 1:210 (0.5%)

 ½ DQ2:DQA1*05

 1:1842 (0.05%)

 No HLA-DQA/DQB susceptibility alleles

 1:2518 (<0.4%)

Instructions

Fasting is not required. Take all medications as prescribed. The HLA-DQ Genetic Test for celiac disease susceptibility comes conveniently packaged as a kit with all necessary components and a complete set of instructions for easy collection. Three buccal (cheek) swabs are collected in the comfort of your home and shipped directly to the testing laboratory in a pre-paid envelope.

Note

A positive result is not diagnostic for celiac disease. Positive results are indicative of a higher probability for celiac disease but need to be interpreted in the light of clinical symptoms and/or a small bowel biopsy.3 Negative results do not rule out the possibility of having celiac disease, they indicate an extremely low risk for development of the disease. Since DNA is being evaluated, this test is effective for people on a gluten-free diet. Additionally, this test only needs to be performed once since a person's genes do not change over time.

Results take 2-3 weeks from when specimen is received. This test is not available in Pennsylvania.

References

  1. Green PHR, Cellier C, Celiac disease. N Engl J Med. 2007; 357:1731-1743
  2. Green PHR. Mortality in Celiac Disease, intestinal inflammation and gluten sensitivity. JAMA. 2009; 302:1225-1226.
  3. Snyder CL, Young DO, Green PHR, Taylor AK. Celiac disease. In: Pagon RA, Bird TC, Dolan CR, Stephens K, editors. GeneReviews (Internet), University of Washington, Seattle, July 3, 2008:1-27. Available at http://ncbi.nim.nih.gov/bookshelf/br.fcgi?book=gene&part=celiac. PMID 20301720 (PubMed)
  4. Sollid LM. Coeliac disease: A complex inflammatory disorder. Nat Rev Immunol. 2002; 2:647-655.
  5. Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology. 2006; 131:1981-2002.
  6. Megiorni F, Mora B, Bonamico M, et al. HLA-DQ and risk gradient for celiac disease. Hum Immunol 2009; 70: 55-59
  7. Pietzak MM, Schofield TC, McGinnis MF, and Nakamura RM. Stratifying risk for celiac disease in a large at-risk United States population by using HLA alleles. Clin Gastroenterol Hepatol 2009; 7: 966-971.

The laboratory services are for informational purposes only. It is not the intention of National Diagnostics, Inc and Life Extension to provide specific medical advice but rather to provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical advice, diagnosis or treatment.

Both the physician and the testing laboratory are independent contractors with whom National Diagnostics, Inc makes arrangements for your blood tests. Neither National Diagnostics, Inc or Life Extension will be liable for any acts or omissions of the physician, the testing laboratory, or their agents or employees.

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