Life Extension Magazine December 2004
By Heather S. Oliff, PhD
|LE Magazine December 2004|
|Flower Pollen |
Powerful Protection for Prostate Health
by Heather S. Oliff, PhD
Other Beneficial Phytotherapeutics
Over all, the clinical studies concluded that saw palmetto improves symptoms of benign prostatic hyperplasia, including urinary flow rate, nocturia, painful urination, residual urine, and inflammation.17 Saw palmetto may produce its effect by lowering levels of DHT in prostate tissue. Animal studies demonstrate that saw palmetto induces apoptosis (programmed cell death), inhibits cell proliferation, and prohibits the action of estrogen in the prostate.17 Saw palmetto is well tolerated, though gastrointestinal disturbance has been reported in rare cases.17
Omega-3 Fatty Acids (Fish Oils)
A low-fat diet supplemented with omega-3 fatty acids from fish oil may prevent the development and progression of prostate cancer and possibly benign prostatic hyperplasia by altering COX-2 expression and prostaglandin production in prostatic tissue.19 COX-2 is an enzyme that converts omega-6 fatty acids to prostaglandins, which stimulate inflammation and the growth of new blood vessels to feed a growing tumor. The potential for omega-3 fatty acids contained in fish oils to prevent benign prostatic hyperplasia and prostate cancer requires further study, but the preliminary evidence is encouraging.
Lycopene’s antioxidant activity is at least twice as great as that of beta-carotene. Extensive scientific evidence demonstrates that increased consumption of tomato products and other lycopene-containing foods may reduce the occurrence or progression of prostate cancer.27 Scientists evaluating 1,872 men with and without prostate cancer discovered that there is a lower risk of prostate cancer in men with higher plasma levels of lycopene.27 In a smaller study, scientists found that consuming tomato sauce entrees (containing 30 mg of lycopene daily) increased apoptosis in benign prostatic hyperplasia cells.28 Additional large-scale studies are needed to confirm this exciting finding.
Considering that the precise cause of benign prostatic hyperplasia remains unknown, it stands to reason that a product such as Cernitin®, which contains several phytotherapies with various mechanisms of action, may be the most effective way to both prevent and treat benign prostatic hyperplasia. With its demonstrated benefits and lack of side effects, Cernitin® is an important addition to the arsenal of products for prostate health.
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17. Blumenthal M, ed. The ABC Clinical Guide to Herbs. Austin, TX: American Botanical Council; 2003.
18. Terry P, Lichtenstein P, Feychting M, Ahlbom A, Wolk A. Fatty fish consumption and risk of prostate cancer. Lancet. 2001 Jun 2;357(9270):1764-66.
19. Aronson WJ, Glaspy JA, Reddy ST, Reese D, Heber D, Bagga D. Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer. Urology. 2001 Aug;58(2):283-8.
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22. Ding VD, Moller DE, Feeney WP, et al. Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway. Endocrinology. 1998 Jan;139(1):213-8.
23. Wilt TJ, Ishani A, Mac Donald R, Rutks I, Stark G. Pygeum africanum for benign prostatic hyperplasia (Cochrane Review). The Cochrane Library. Vol Issue 3. Chichester, UK: John Wiley & Sons, Ltd.; 2004.
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28. Kim HS, Bowen P, Chen L, et al. Effects of tomato sauce consumption on apoptotic cell death in prostate benign hyperplasia and carcinoma. Nutr Cancer. 2003;47(1):40-7.
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