Why Aging Women NeedApril 2004
By Edward R. Rosick, DO, MPH, MS
Ways to Increase Testosterone Naturally
Multiple studies have shown that resistance exercise can increase men’s testosterone levels. Some lesser-known but equally impressive studies show that exercise likewise can increase women’s testosterone levels, whether they are 20 or 60 years old. A study in 2001 examined the acute effects of resistance exercise in 47 women aged 19 to 25.10 After just six sets of repetitive motion squat exercises, significant increases were noted in both free and total testosterone levels. A study in 2002 examined the effects of endurance and resistance exercise on hormonal levels, including testosterone, in women 19-69 years of age.11 As in the previous study, testosterone levels increased significantly in women who did either endurance or resistance exercises, regardless of their age. Another study conducted in 2003, which examined the hormonal effects of high-impact physical exercise in 25 early postmenopausal women aged 53-59, showed a significant and acute rise in testosterone levels following exercise.12
Like testosterone, DHEA is a hormone that has long been recognized by holistic practitioners as essential for optimal health in women and men. DHEA is secreted into the bloodstream by the adrenals in humans and other primates, and then converted into DHEA sulfate (DHEA-S). Since DHEA’s discovery, hundreds of scientific articles have been published on its wide-ranging effects.
DHEA is a precursor to testosterone and estrogen. As with testosterone, DHEA levels peak in women in their twenties and then slowly but steadily decline, dropping by about 10% every decade of life. Some intriguing early studies have correlated the decline in DHEA production with many of the degenerative changes seen in aging in women and men, such as heart disease, cancer, and osteoporosis.13
While it is considered physiologically “normal” for DHEA to decline during aging, under certain conditions DHEA levels plummet early in life. Addison’s disease, or primary adrenal failure, occurs in about 1 in every 25,000 people. Without functioning adrenal glands, the body cannot produce many important steroid hormones, including DHEA. Standard treatment for this condition has been to replace the missing hormones. Until very recently, however, most mainstream physicians did not replace DHEA. Furthermore, patients with Addison’s disease, even those who received standard hormone replacement therapy, consistently report a reduced quality of life with symptoms such as persistent fatigue and depression.
A recent study looked at the effects of DHEA supplementation in patients with Addison’s disease.13 In this randomized, double-blind trial, 39 patients (24 women and 15 men, aged 25-69) were given either 50 mg of DHEA daily for 12 weeks, followed by a four-week washout period, then 12 weeks of placebo, or vice versa. After DHEA supplementation, blood levels of DHEA rose from subnormal (as would be expected in Addison’s disease) to the normal range for young adults. More important, both the women and men taking DHEA showed significant positive psychological changes, including enhancements in self-esteem and mood and a decrease in fatigue.
Besides Addison’s disease, other conditions cause a significant decrease in DHEA levels. Adrenal insufficiency is a condition in which the adrenal glands secrete some hormones, but not at normal levels. In a double-blind study of 24 women with adrenal insufficiency, DHEA supplementation (50 mg daily for four months) raised DHEA-S levels to normal.14 It also increased the women’s sense of well being and frequency of sexual thoughts and interest, as well as decreased depression and anxiety.
DHEA Delays Aging’s Physical Effects
DHEA and Optimizing Testosterone
60 perimenopausal women aged 45-55, also examined the effects of DHEA supplementation (50 mg per day) on testosterone and other hormone levels over a three-month period.17 Again, women who took DHEA supplements had significantly higher testosterone levels than women who were in the placebo group. Finally, a study was done that examined the hormonal effects of DHEA (50 mg per day) on 31 women, aged 50-65 years, over a six-month period.18 Like the previously cited studies, women who took DHEA had higher levels of testosterone as well as other “beneficial” hormones such as growth hormone, which led the authors of the study to conclude that “DHEA is more than a simple diet supplement or anti-aging product; rather, it should be considered an effective hormonal replacement treatment.”
DHEA and Sexual Function
Slowly and begrudgingly, mainstream medicine is beginning to realize that those who believe in the power of integrative medicine may be on to something very important. As more studies show that supplements like DHEA and hormones such as testosterone can help women maintain their zest for life (and for sex) throughout their lives, it is only a matter of time until all women, whether or not they have a physician who is well versed in integrative medicine, will be able to receive the medical care and guidance they deserve to live long and healthy lives.
1. Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual functioning after oophorectomy. N Engl J Med. 2000 Sep 7;343(10):682-8.
2. Davis S. Androgen replacement in women: a commentary. J Clin Endocrinol Metab. 1999 Jun;84(6):1886-91.
3. Davis SR. Androgens and female sexuality. J Gend Specif Med. 2000 Jan-Feb;3(1):36-40.
4. Davis SR, McCloud P, Strauss BJ, Burger H. Testosterone enhances estradiol’s effects on postmenopausal bone density and sexuality. Maturitas. 1995 Apr;21(3):227-36.
5. Lovejoy JC, Bray GA, Bourgeois MO, et al. Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women—a clinical research center study. J Clin Endocrinol Metab. 1996 Jun;81(6):2198-203.
6. Rako S. Testosterone deficiency: a key factor in the increased cardiovascular risk to women following hysterectomy or with natural aging? J Womens Health. 1998 Sep;7(7):825-9.
7. Berrino F, Muti P, Micheli A, et al. Serum sex hormone levels after menopause and subsequent breast cancer. J Natl Cancer Inst. 1996 Mar 6;88(5):291-6.
8. Zhou J, Ng S, Adesanya-Famuiya O, Anderson K, Bondy CA. Testosterone inhibits extrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB J. 2000 Sep;14(12):1725-30.
9. Dimitrakakis C, Zhou J, Wang J, et al. A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause. 2003 Jul-Aug;10(4):292-8.
10. Nindl BC, Kraemer WJ, Gotshalk LA, et al. Testosterone responses after resistance exercise in women: influence of regional fat distribution. Int J Sport Nutr Exerc Metab. 2001 Dec;11(4):451-65.
11. Copeland JL, Consitt LA, Tremblay MS. Hormonal responses to endurance and resistance exercise in females aged 19-69 years. J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):B158-65.
12. Kemmler W, Wildt L, Engelke K, et al. Acute hormonal responses of a high impact physical exercise session in early post menopausal women. Eur J Appl Physiol. 2003 Sep;90(1-2):199-209. Epub 2003 Jul 09.
13. Hunt PJ, Gurnell EM, Huppert FA, et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison’s disease in a randomized, double blind trial. J Clin Endocrinol Metab. 2000 Dec;85(12):4650-6.
14. Arlt W, Callies F, van Vlijmen JC, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med. 1999 Sep 30;341(14):1013-20.
15. Morales AJ, Nolan JJ, Nelson JC, Yen SS. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab. 1994 Jun;78(6):1360-7.
16. Rubino S, Stomati M, Bersi C, et al. Neuroendocrine effect of a short-term treatment of DHEA in postmenopausal women. Maturitas. 1998 Jan 12;28(3):251-7.
17. Barnhart KT, Freeman E, Grisso JA, et al. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-relat- ed quality of life. J Clin Endocrinol Metab. 1999 Nov;84(11):3896-902.
18. Genazzani AD, Stomati M, Strucchi C, Puccetti S, Luisi S, Genazzani AR. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Fertil Steril. 2001 Aug;76(2):241-8.
19. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4279-84.
20. Munarriz R, Talakoub L, Flaherty E, et al. Androgen replacement therapy with dehy- droepiandrosterone for androgen insufficiency and female sexual dysfunction: androgen and questionnaire results. J Sex Marital Ther. 2002;28 Suppl 1:165-73.