Aging and GlycationApril 2008
By Steven V. Joyal, MD
Physicians and patients alike are beginning to realize that there is a valuable blood test that can help assess the level of glycation, a process implicated in accelerated aging.
The hemoglobin A1c test is a well known tool for following long-term glucose control in patients with diabetes. However, the same blood test also helps identify age-accelerating glycation reactions in the body. The hemoglobin A1c blood test is thus useful in non-diabetics who want to guard against this destructive glycation process.Here, we’ll examine the importance of making sure your hemoglobin A1c is in a safe range and what to do if it is not.
What is Hemoglobin A1c?
Developed nearly 40 years ago, hemoglobin A1c is a common, readily available blood test that is used most frequently to assess glucose control in diabetic patients. This test provides information about glycation levels, which, if increased, is a key factor not only in diabetes and its complications, but also an important contributor to premature aging and disease risk.1-4
Measuring hemoglobin A1c is different from a single fasting blood glucose test, which only provides a snapshot of one’s current blood sugar level and is subject to daily variation. In contrast, the hemoglobin A1c test shows the bigger picture of a weighted average of blood sugar levels over the past three to four months.5-7 This simple test is thus a powerful measure of elevated long-term blood sugar and glycation levels, which scientists believe may be intimately involved in accelerated aging.8
However, this valuable tool is being dramatically underutilized in the context of aging. The hemoglobin A1c test measures the presence of glucose molecules that join hemoglobin in a destructive process called glycation. The formation of glycated hemoglobin in red blood cells is thus termed hemoglobin A1c. The hemoglobin A1c test therefore identifies the potential for age-accelerating glycation reactions in our bodies, which are implicated in many life-threatening diseases.8-11 Glycation plays an important role in the development of diabetic retinopathy resulting in blindness, diabetic neuropathy resulting in nerve damage, and diabetic nephropathy resulting in kidney failure.12
Applications in Diabetic and Healthy Individuals
The hemoglobin A1c test is commonly used every three months to assess blood sugar control and glycation in patients with pre-diabetes or diabetes. This critical test also predicts future risk of developing diabetic complications largely caused by the damage of glycation upon tissues of the body.13
Scientists now believe that it is not only those with diabetes or pre-diabetes who should be concerned about the damaging effects of glycation in the body. New studies reveal that all of us may suffer from the damage inflicted by advanced glycation end-products (AGEs), which are formed when sugars bind with proteins or amino acids in the body. Recent research indicates that these damaging end products play a role in heart disease, cancer, neurodegeneration, and the aging process itself.8-11,14 Thus, diligently monitoring hemoglobin A1c levels is essential for all adults who wish to identify excess glycation processes in their bodies and take measures to control and minimize glycation-induced damage.
The Optimal Level of Hemoglobin A1c
Higher long-term blood glucose levels adversely impact hemoglobin A1c: for example, a hemoglobin A1c of 6% roughly represents an average blood glucose level of 135 mg/dL, and 5% roughly represents an average blood glucose level of 90 mg/dL.15 However, research shows that glucose is not the only factor involved in glycation. For example, a study in type 1 diabetic patients revealed that hemoglobin A1c showed significant variability and, in 60% of cases, a reverse relationship between glycation and average blood glucose level (for example, some individuals showed higher levels of glycation and lower relative levels of blood glucose). Clearly, more than just blood glucose impacts our bodies’ level of glycation.16
Since the goal for many of us is a long, prosperous life free from dependency upon loved ones or nursing home caretakers, current scientific evidence suggests that aging people as well as people who have diabetes should aggressively monitor their hemoglobin A1c, striving for a value lower than 6.5%.17-20 For optimal longevity (remember, diabetes is a form of accelerated aging), scientific research suggests that a hemoglobin A1c level of less than 5% is ideal.17,21
Testing for Hemoglobin A1c in Aging Adults
Aging individuals with a fasting glucose level above 85 mg/dL should consider having a hemoglobin A1c blood test in order to assess long-term blood sugar levels and to help identify the level of age-accelerating glycation occurring in the body.
Because of the lack of standardized measuring techniques among laboratories, hemoglobin A1c tests should be read by the same laboratory, or by labs that are standardized to the national DCCT reference method. If your hemoglobin A1c level is elevated above optimal, work with your health care practitioner to take aggressive steps to control this important factor involved in premature aging and disease.
Nutrients that most Life Extension members take already, such as lipoic acid, carnosine, and benfotiamine all help block glycation reactions in the body.
For those interested in optimal metabolic control and longevity, reducing blood glucose to an ideal range (between 70 and 85 mg/dL) along with achieving hemoglobin A1c less than 5% are important goals.
If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at 1-800-226-2370.
1. O’Sullivan JB, Mahan CM. Mortality related to diabetes and blood glucose levels in a community study. Am J Epidemiol. 1982 Oct;116(4):678-84.
2. Asadollahi K, Beeching N, Gill G. Hyperglycaemia and mortality. J R Soc Med. 2007 Nov;100(11):503-7.
3. Palumbo F, Bianchi C, Miccoli R, Del PS. Hyperglycaemia and cardiovascular risk. Acta Diabetol. 2003 Dec;40(Suppl 2):S362-9.
4. DeGroot J. The AGE of the matrix: chemistry, consequence and cure. Curr Opin Pharmacol. 2004 Jun;4(3):301-5.
5. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/003640.htm. Accessed January 16, 2008.
6. Dailey G. Assessing glycemic control with self-monitoring of blood glucose and hemoglobin A(1c) measurements. Mayo Clin Proc. 2007 Feb;82(2):229-35.
7. Osterman-Golkar SM, Vesper HW. Assessment of the relationship between glucose and A1c using kinetic modeling. J Diabetes Complications. 2006 Sep;20(5):285-94.
8. Robert L, Robert AM, Fulop T. Rapid increase in human life expectancy: will it soon be limited by the aging of elastin? Biogerontology. 2008;Jan 4.
9. Vasdev S, Gill V, Singal P. Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications. Cell Biochem Biophys. 2007;49(1):48-63.
10. Whitmer RA. Type 2 diabetes and risk of cognitive impairment and dementia. Curr Neurol Neurosci Rep. 2007 Sep;7(5):373-80.
11. Yamagishi S, Adachi H, Takeuchi M, et al. Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population. Horm Metab Res. 2007 Nov;39(11):845-8.
12. Nawale RB, Mourya VK, Bhise SB. Non-enzymatic glycation of proteins: a cause for complications in diabetes. Indian J Biochem Biophys. 2006 Dec;43(6):337-44.
13. Landgraf R. HbA1c—the gold standard in the assessment of diabetes treatment? Dtsch Med Wochenschr. 2006 Dec;131(Suppl 8):S243-6.
14. Takeuchi M, Yamagishi S. TAGE (toxic AGEs) hypothesis in various chronic diseases. Med Hypotheses. 2004;63(3):449-52.
15. Available at: http://labtestsonline.org/understanding/analytes/a1c/test.html. Accessed January 18, 2008.
16. Hudson PR, Child DF, Jones H, Williams CP. Differences in rates of glycation (glycation index) may significantly affect individual HbA1c results in type 1 diabetes. Ann Clin Biochem. 1999 Jul;36(Pt 4):451-9.
17. Geberhiwot T, Haddon A, Labib M. HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose. Ann Clin Biochem. 2005 May;42(Pt 3):193-5.
18. Harper JM, Durkee SJ, Smith-Wheelock M, Miller RA. Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock. Exp Gerontol. 2005 Apr;40(4):303-14.
19. Kalantar-Zadeh K, Kopple JD, Regidor DL, et al. A1C and survival in maintenance hemodialysis patients. Diabetes Care. 2007 May;30(5):1049-55.
20. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care. 2003 Jan;26 Suppl 1:S33-50.
21. Baron P. The ten most important blood tests. Life Extension. 2006 May;12(5):42-51.
22. Yudkin JS, Forrest RD, Jackson CA, Ryle AJ, Davie S, Gould BJ. Unexplained variability of glycated haemoglobin in non-diabetic subjects not related to glycaemia. Diabetologia. 1990 Apr;33(4):208-15.