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Life Extension Magazine

Why Aging People Fail to Lose Weight

June 2009

By William Faloon

Combat These Obesity-Inducers

Combat These Obesity-Inducers

In response to compelling evidence that unwanted weight gain is a multi-factorial process, Life Extension® has developed the world’s most comprehensive fat-loss program! One prong of this aggressive multi-model approach is a new formula that provides four ingredients, three that have clinically substantiated weight-loss benefits (the fourth has strong laboratory data to support its efficacy).1,11-13

This new Enhanced Irvingia formula provides an amylase inhibitor that took 1.2 inches of abdominal fat off human study subjects in only 30 days,14 and a non-stimulating booster of resting metabolic rate (proprietary green tea phytosome) that when combined with calorie reduction, resulted in 30 pounds of weight loss in 90 days. The placebo group who followed this same lifestyle modification (without the tea phytosome) lost only 9.9 pounds.15

Another effect of this novel metabolic enhancer is to inhibit the lipase enzyme used by the body to break down and absorb dietary fats16 (though many people may still consider the temporary use of a more potent lipase-inhibiting drug we will suggest).17,18

In order to optimally impede carbohydrate (sugar) absorption, more than an amylase inhibitor is often needed. Alpha-glucosidase is another enzyme the body uses to assimilate carbohydrates from the small intestine.19 The new Enhanced Irvingia contains an alpha-glucosidase inhibitor that in laboratory studies resulted in a 90% reduction in postprandial blood glucose spikes with a dramatic 40% reduction in postprandial insulin.13

This new formula contains the standardized Irvingia gabonensis used in the most recent human study to induce weight loss and a reduction in abdominal adiposity via four different mechanisms.1,13-15

Managing Unrealistic Expectations

Based on the multiple pathways that the four ingredients in the new Enhanced Irvingia function, overweight members may think this one formula will make them thin again. While this formula may function in an impressive manner for some individuals, the majority of people will need to follow at least some of the aggressive protocols laid out in the articles contained in this month’s issue of Life Extension® magazine.

Please know that even in tightly regimented clinical studies, doctors find it remarkably challenging to manage the weight-loss expectations of study participants. One study documented that no matter how many times study subjects were told that they would not achieve immediate results, many dropped out because they were not losing weight fast enough.20

Based on the accumulation of everything we now know, the only way for most people to achieve substantial and sustained control over their body weight is to adopt the clearly defined protocols outlined in the articles you are about to read.

You Don’t Have to Go it Alone!

Many of our members are proficient enough to comprehend these new weight-loss data and incorporate the protocols we suggest into their everyday lifestyle.

If you are ever confused by what we publish, please remember that as a Life Extension member, you have direct access to our dedicated team of health advisors.

For instance, if you utilize the new Life Extension Weight Loss Blood Test Panel (click here for panel), you can call a health advisor and ask what specifically you should do to achieve optimal weight loss. Our health advisors will listen to your personal history and make suggestions based on the obesity factors (as revealed by your blood tests) that may be causing you to be overweight or obese.

If after you implement some of the strategies we outline, you are not satisfied with your achieved weight-loss result, our health advisors may be able to identify the missing link(s) that preclude you from shedding excess fat pounds.

Clinically Proven Weight-Loss Strategies

Our position, based on a myriad of published findings, is that sustained weight loss is achievable. The problem up until now is that no one put together all the pieces to enable aging humans to avail themselves of proven fat-reducing strategies.

In this month’s issue, you’ll learn about methods that have been documented in human clinical trials (and some approved by the FDA) to safely induce weight loss—while simultaneously improving cardiac risk markers.

P.S. Our health advisors are available from 8 am to 12 midnight Eastern Standard Time seven days a week and can be reached by calling 1-800-226-2370.

For longer life,

For Longer Life

William Faloon


1. Lipids Health Dis. 2009 Mar 2;8:7.

2. Lipids Health Dis. 2008 Nov 13;7:44.

3. Lipids Health Dis. 2008 Mar 31;7:12.

4. West Afr J Med. 1990 Apr-Jun;9(2):108-15.

5. Lipids Health Dis. 2005 May 25;4:12.

6. Ann Pharmacother. 2001 Mar;35(3):314-28.

7. Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):717-42.

8. Curr Diabetes Rev. 2008 Nov;4(4):340-56.

9. J Am Diet Assoc. 1998 Oct;98(10 Suppl 2):S23-6.

10. Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E626-32.

11. Altern Med Rev. 2004 Mar;9(1):63-9.

12. Integr Nutr. 2008;11(2):15-21.

13. http://www.innovactiv.com/index.php?option=com_content&task=view&id=18&Itemid=34.

14. Int J Med Sci. 2007 Jan 24;4(1):45-52.

15. Nutrafoods. 2008;7(4):21-8.

16. J Nutr Biochem. 2006 Jul;17(7):492-8.

17. Drugs Today (Barc). 1999 Feb;35(2):139-45.

18. Obes Res. 2000 Jan;8(1):49-61.

19. Eur J Clin Invest. 1994 Aug;24(Suppl 3):3-10.

20. J Consult Clin Psychol. 2003 Dec;71(6):1084-9.