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A Prescription for Beautiful and Healthy Legs

By Robert Haas, MS

September 2009

By Robert Haas, MS

A Prescription for Beautiful and Healthy Legs

For the last 30 years, millions of European women have been using a doctor-prescribed citrus fruit extract to attain healthier, smoother, and shapelier legs.

Now, US women have access to the same European wonder drug, available without a doctor’s prescription as a nutraceutical product, called micronized diosmin. Micronized diosmin has been clinically proven to produce healthier-looking legs by healing swollen ankles, spider and varicose veins, and leg ulcers.

While current US drug treatments for cosmetic improvement in the legs have not achieved good clinical efficacy, micronized diosmin has enjoyed an outstanding 30-year record of research testing and success in Europe.1

In this article, you’ll learn about the new nonprescription form of the European drug, micronized diosmin, and discover how it can enhance the appearance of the legs by reducing ankle swelling, improving the appearance of varicose and spider veins, and restoring healthy vascular function in people suffering from chronic venous disorders.

Micronized Diosmin Restores Healthy Function to Stressed-Out Legs

Age and gravity are the enemies of healthy veins. Over time, leg veins may become weakened, twisted, dilated, and thickened. Blood may flow backwards and collect in the vein, causing it to swell. Aside from the visible, unsightly cosmetic issues, spider veins and varicose veins cause pain and itching, while scratching them can lead to ulcerations. Mainstream doctors treat these swollen and unsightly veins with lasers, radiofrequency ablation, and surgery.

Micronized diosmin prolongs the vasoconstrictor effect of noradrenalin on the vein wall and by doing so, increases venous tone, thereby reducing the blood pooling that can lead to swollen leg veins.4

With micronized diosmin, people who suffer from swollen veins may be able to avoid expensive medical procedures, and research has shown that those who must undergo such procedures may see improved clinical outcomes when it is used pre- and post-operatively.

In a study of 245 patients with varicose vein disease who underwent surgical removal of affected veins, those given micronized diosmin pre- and post-therapy (two weeks before and for 30 consecutive days after surgery) achieved measurable reduction in postoperative hematomas, pain severity, and limb heaviness, as well as better exercise tolerance and improved quality of life scores.5

Protection Against Varicose Veins

The role of the legs’ venous system is to return deoxygenated blood from the lower extremities to the heart. To counterbalance the effect of gravity, leg veins are equipped with a series of one-way valves that prevent the return of blood flow to the feet. In people with healthy venous valves, each contraction of the calf muscles pumps venous blood toward the heart. As valves become damaged, they allow retrograde flow of blood toward the feet, leading to hypertension in the veins and further complications linked to progression of chronic venous disease. This leads to damage of the venous wall, the appearance of varicose veins, and further damage leading to the progression of venous disease.

Micronized Diosmin: The First Nutraceutical for Beautiful Legs

Diosmin is a naturally occurring hesperidin bioflavonoid. Pharmaceutical grade diosmin is extracted from the rinds of sweet oranges. The sweet orange, a hybrid of the pomelo and tangerine, was originally cultivated in southeast Asia. It was then brought to Spain in the ninth century and later to Florida by Spanish explorers during the 1500s.

The most clinically effective diosmin is micronized, which means it has undergone a scientifically controlled process to reduce the size of standard particles in order to increase its bio-availability and to achieve rapid relief of symptoms and to accelerate healing.2,3

For the estimated 12 to 25 million people in the United States who suffer with “cankles” (loss of definition between calves and ankles due to swelling) and unsightly and painful varicose veins and spider veins, micronized diosmin may offer a safe and effective non-surgical treatment option.

Studies show that micronized diosmin protects the one-way venous valves from leukocyte-induced inflammation and destruction.6 Micronized diosmin also increases venous tone and reduces venous stretching and blood pooling.7 This increases blood flow toward the heart and reduces venous high blood pressure present in patients suffering from chronic venous disease.

Dangers of Chronic Venous Insufficiency (CVI)

If your legs feel heavy, tired, or achy, or if you feel pain in your legs shortly after walking, you might have chronic venous insufficiency (CVI).

Dangers of Chronic Venous Insufficiency (CVI)

CVI is caused by a deterioration of the one-way flaps in veins designed to keep blood flowing toward the heart. With each step taken, venous flaps serve as leaflet valves that maintain blood flow in the proper direction. As leg muscles relax, the venous valves close, preventing blood from flowing back down the leg.

CVI generally affects deep veins in the leg. Varicose veins can also contribute to CVI. Doctors treat CVI with compression bandaging, drugs, sclerotherapy (injections), and surgery. The process of venous wall stretching and dilation is painful and generally leads to leg heaviness and a sensation of swelling.

Although generally not life-threatening, CVI can decrease quality of life; left untreated, it can lead to serious medical conditions including phlebitis, the inflammatory venous condition that afflicted President Richard Nixon, and deep vein thrombosis (DVT), suffered by Vice-President Dan Quayle as a result of extended air travel. DVT can cause a potentially life-threatening blood clot.

Risk factors for CVI include being in a profession that involves standing or sitting for long periods of time, age, gender (women older than 50 are more prone than men to CVI), being pregnant, physical activity, smoking, body fatness, height (taller people are at greater risk) and a family history of varicose veins.

Studies using micronized diosmin for the treatment of CVI reveal that in as little as 30 days, most patients suffering from this condition see significant improvement in pain, sensation of swelling, and cramps.8,9

A multicenter international trial, conducted in 23 countries over two years, in which 5,052 symptomatic patients were enrolled, evaluated the efficacy of micronized diosmin in the treatment of chronic venous insufficiency.9 Researchers noted continuous clinical improvement throughout the study, as well as improvements in quality-of-life scores for participants.

Diosmin Blocks The Primary Cause of All Chronic Venous Disease

Researchers recently discovered that the interaction between white blood cells (leukocytes) and the venous endothelium (inner layer of vein wall) is the process underlying all clinical manifestations of chronic venous disease. Thanks to its unique action in inhibiting this leukocyte-endothelial interaction, micronized diosmin is the only nutraceutical treatment shown to be effective and protective against the progression of chronic venous disease.

What You Need to Know: Micronized Diosmin
  • Millions of European women have used micronized diosmin to achieve smoother, shapelier, and more slender looking legs. Now, diosmin is available in the US as a dietary supplement.
  • Micronized diosmin improves the symptoms and appearance of varicose and spider veins, heavy leg syndrome, and chronic venous insufficiency (CVI).
  • Micronized diosmin reduces pain and swelling in the legs and ankles, helping the legs feel lighter and ultimately look better.
  • Micronized diosmin alleviates the acute and chronic pain and swelling of hemorrhoids.
  • Venous leg ulcers show marked improvement with micronized diosmin.
  • Micronized diosmin helps relieve lymphedema that can occur after treatment for breast cancer.
  • Micronized diosmin has an outstanding safety record, however, pregnant women and people taking prescription medications should check with a doctor before using it.

Leukocyte-endothelium interaction is caused by the expression of adhesion molecules on the surface of leukocytes and endothelial cells. As a result of this interaction, leukocytes release proteolytic enzymes and other toxic components, producing a massive inflammatory response in small veins and capillaries. This leads to the accumulation of red blood cells, fluids, and proteins that cause ankle swelling (edema) and inflammation.10 Over time, this inflammatory process may cause leg veins and the skin to ulcerate.

Diosmin protects capillaries and the microcirculation from inflammation and vascular-destructive compounds while inhibiting white blood cell activation, migration, and adhesion. Likewise, micronized diosmin prevents tissue damage to blood vessel valves; preventing venous blood backflow. Micronized diosmin is the only treatment that is effective in protecting patients from the symptoms of chronic venous disease from the earliest stages up to the most severe stages.11-14

After reviewing a number of medical studies using micronized diosmin, one researcher concluded that micronized diosmin should be “the first-line treatment for edema and symptoms of CVI at any stage of the disease” and recommended its use “in conjunction with sclerotherapy, surgery, and/or compression therapy or as an alternative treatment when other treatments are not indicated or not feasible.”7

Why You Should Use Only Micronized Diosmin

Micronization is a technique that reduces the size of particles and therefore improves the rate of dissolution and absorption of otherwise poorly soluble drugs and other compounds.

One problem with most diosmin products on the market has been their poor absorption and poor bioavailability, which leads to the necessity of taking extremely high doses in order to obtain even modest clinical efficacy.

The bioavailability of a compound is defined as the amount of the administered dose that reaches the systemic circulation (bloodstream). It is a widely accepted pharmacologic principle that the smaller the particles of a compound administered by the oral route, the higher the rate of dissolution and absorption of that product

For this reason, clinical studies only use micronized diosmin, which means that the manufacturer has subjected the diosmin to a high-tech grinding process with a jet of air at supersonic velocities, reducing the size of standard diosmin particles from 37 µm to less than 2 µm. Thanks to its unique form, micronized diosmin products are at least 30% more bioavailable, which may increase their clinical efficacy over nonmicronized, ordinary diosmin products.3